| Description : |
The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein. |
| Source : |
In Vitro Cell Free System |
| Species : |
Human |
| Form : |
Liquid |
| Molecular Mass : |
84.850kDa inclusive of tags |
| Protein Length : |
534 amino acids |
| AA Sequence : |
PCHTAARSECKRSHKFVPGAWLAGEGVDVTSLRRSGSFPV DTQRFLRPDGTCTLCENALQEGTLQRLPLALTNWRAQGSG CQRHVTRAKVSSTEAVARDAARSIRNDWKVGLDVTPKPTS NVHVSVAGSHSQAANFAAQKTHQDQYSFSTDTVECRFYSF HVVHTPPLHPDFKRALGDLPHHFNASTQPAYLRLISNYGT HFIRAVELGGRISALTALRTCELALEGLTDNEVEDCLTVE AQVNIGIHGSISAEAKACEEKKKKHKMTASFHQTYRERHS EVVGGHHTSINDLLFGIQAGPEQYSAWVNSLPGSPGLVDY TLEPLHVLLDSQDPRREALRRALSQYLTDRARWRDCSRPC PPGRQKSPRDPCQCVCHGSAVTTQDCCPRQRGLAQLEVTF IQAWGLWGDWFTATDAYVKLFLGGQELRTSTVWDNNNPIW SVRLDFGDVLLATGGPLRLQVWDQDSGRDDDLLGTCDQAP KSGSHEVRCNLNHGHLKFRYHARCLPHLGGGTCLDYVPQM LLGEPPGNRSGAVW |
| Purity : |
Proprietary Purification |
| Storage : |
Shipped on dry ice. Upon delivery aliquot and store at -80 centigrade. Avoid freeze / thaw cycles. |
| Storage Buffer : |
pH: 8.00. Constituents:0.79% Tris HCl, 0.31% Glutathione. |
