Description : |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
67.7 kDa |
AA Sequence : |
MLSRGWFHRDLSGLDAETLLKGRGV HGSFLARPSRKNQGDFSLSVRVGDQ VTHIRIQNSGDFYDLYGGEKFATLT ELVEYYTQQQGVLQDRDGTIIHLKY PLNCSDPTSERWYHGHMSGGQAETL LQAKGEPWTFLVRESLSQPGDFVLS VLSDQPKAGPGSPLRVTHIKVMCEG GRYTVGGLETFDSLTDLVEHFKKTG IEEASGAFVYLRQPYYATRVNAADI ENRVLELNKKQESEDTAKAGFWEEF ESLQKQEVKNLHQRLEGQRPENKGK NRYKNILPFDHSRVILQGRDSNIPG SDYINANYIKNQLLGPDENAKTYIA SQGCLEATVNDFWQMAWQENSRVIV MTTREVEKGRNKCVPYWPEVGMQRA YGPYSVTNCGEHDTTEYKLRTLQVS PLDNGDLIREIWHYQYLSWPDHGVP SEPGGVLSFLDQINQRQESLPHAGP IIVHCSAGIGRTGTIIVIDMLMENI STKGLDCDIDIQKTIQMVRAQRSGM VQTEAQYKFIYVAIAQFIETTKKKL EVLQSQKGQESEYGNITYPPAMKNA HAKASRTSSKHKEDVYENLHTKNKR EEKVKKQRSADKEKSKGSLKRKTRT RPLEQKLISEEDLAANDILDYKDDD DKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |