| Description : |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
67.4 kDa |
| AA Sequence : |
MVRWFHRDLSGLDAETLLKGRGVHG SFLARPSRKNQGDFSLSVRVGDQVT HIRIQNSGDFYDLYGGEKFATLTEL VEYYTQQQGVLQDRDGTIIHLKYPL NCSDPTSERWYHGHMSGGQAETLLQ AKGEPWTFLVRESLSQPGDFVLSVL SDQPKAGPGSPLRVTHIKVMCEGGR YTVGGLETFDSLTDLVEHFKKTGIE EASGAFVYLRQPYYATRVNAADIEN RVLELNKKQESEDTAKAGFWEEFES LQKQEVKNLHQRLEGQRPENKGKNR YKNILPFDHSRVILQGRDSNIPGSD YINANYIKNQLLGPDENAKTYIASQ GCLEATVNDFWQMAWQENSRVIVMT TREVEKGRNKCVPYWPEVGMQRAYG PYSVTNCGEHDTTEYKLRTLQVSPL DNGDLIREIWHYQYLSWPDHGVPSE PGGVLSFLDQINQRQESLPHAGPII VHCSAGIGRTGTIIVIDMLMENIST KGLDCDIDIQKTIQMVRAQRSGMVQ TEAQYKFIYVAIAQFIETTKKKLEV LQSQKGQESEYGNITYPPAMKNAHA KASRTSSKHKEDVYENLHTKNKREE KVKKQRSADKEKSKGSLKRKTRTRP LEQKLISEEDLAANDILDYKDDDDK V |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
