| Description : |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. |
| Source : |
Mammalian cells |
| Species : |
Human |
| Tag : |
Flag |
| Form : |
25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
| Molecular Mass : |
67.5 kDa |
| AA Sequence : |
MLSRGWFHRDLSGLDAETLLKGRGV HGSFLARPSRKNQGDFSLSVRVGDQ VTHIRIQNSGDFYDLYGGEK FATLTELVEYYTQQQGVLQDRDGTI IHLKYPLNCSDPTSERWYHGHMSGG QAETLLQAKGEPWTFLVRES LSQPGDFVLSVLSDQPKAGPGSPLR VTHIKVMCEGGRYTVGGLETFDSLT DLVEHFKKTGIEEASGAFVY LRQPYYATRVNAADIENRVLELNKK QESEDTAKAGFWEEFESLQKQEVKN LHQRLEGQRPENKGKNRYKN ILPFDHSRVILQGRDSNIPGSDYIN ANYIKNQLLGPDENAKTYIASQGCL EATVNDFWQMAWQENSRVIV MTTREVEKGRNKCVPYWPEVGMQRA YGPYSVTNCGEHDTTEYKLRTLQVS PLDNGDLIREIWHYQYLSWP DHGVPSEPGGVLSFLDQINQRQESL PHAGPIIVHCSAGIGRTGTIIVIDM LMENISTKGLDCDIDIQKTI QMVRAQRSGMVQTEAQYKFIYVAIA QFIETTKKKLEVLQSQKGQESEYGN ITYPPAMKNAHAKASRTSSK
HKEDVYENLHTKNKREEKVKKQRSA DKEKSKGSLKRKTRTRPLEQKLISE EDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining. |
| Stability : |
Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Storage : |
Store at -80 centigrade. |
| Concentration : |
>50 ug/mL as determined by microplate BCA method. |
| Preparation : |
Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Protein Families : |
Druggable Genome, Phosphatase, Stem cell - Pluripotency |
| Protein Pathways : |
Adherens junction, B cell receptor signaling pathway, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway |
