RAC1
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Official Full Name
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
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Overview
The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] -
Synonyms
RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); MIG5; Rac-1; TC-25; p21-Rac1; ras-related C3 botulinum toxin substrate 1; ras-like protein TC25; cell migration-inducing gene 5 protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Insect Cell
- Insect Cells
- Mammalian Cell
- Mammalian cells
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- RAC1 Related Articles
- RAC1 Related Research Area
- RAC1 Related Signal Pathway
RAC1 involved in several pathways and played different roles in them. We selected most pathways RAC1 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | RPS6KA5;GADD45BA;AKT1;PDGFRB;NFKB1;PPM1AA;HRAS;FGFR2;PPP3CC |
| Ras signaling pathway | KSR1;RASAL2;PRKACA;IKBKG;GNB1;CALM3;FGF19;CALM2;PLA1A |
| Rap signaling pathway | FGF6;ACTG1;PRKCG;Pdgfa&Pdgfb;PIK3CA;F2RL3;NGF;PRKCI;PLCE1 |
| cAMP signaling pathway | FFAR2;RAF1;OXTR;PIK3R2;RHOA;GNAI1;PRKACA;GPR119;MAP2K1 |
| Chemokine signaling pathway | CCR1L1;GRK4;CXCL5;RAP1A;GNB2;GSK3B;FOXO3;GM13306;STAT3 |
| Sphingolipid signaling pathway | BAX;TP53;MAPK8;PPP2R3A;PPP2R5E;AKT1;NOS3;CERS4;PLD2 |
| Phagosome | TFRC;MARCO;SEC61A1;SEC61G;ATP6V0A2;BF1;TUBB2A;TUBA7L;ATP6V1B1 |
| PIK-Akt signaling pathway | FGF11;PRKAA1;MTOR;KRAS;GNG3;ITGA8;NGFR;GHR;LAMB2 |
| Wnt signaling pathway | CXXC4;PPP3R1B;FZD3B;GPC4;TBL1XR1;EP300;PPP3R1;CTNNBIP1;RUVBL1 |
| Axon guidance | PEBP1;FRS2;SHB;FRS2B;ARPC1B;SEMA4A;RASGRP4;NCK2;KCNQ2 |
| VEGF signaling pathway | BAD;NFATC2;PTGS2B;PPP3R2;RAC1B;AKT3A;MAP2K1;PRKCA;PTGS2A |
| Osteoclast differentiation | TAB2;TNF;SFPI1;TGFBR1;FCGR3;LILRB5;PPP3R2;PPP3CC;ACP5 |
| Focal adhesion | MYL12B;ITGB1;MYL5;CAV1;MET;PAK7;RAF1;PTENB;ZYX |
| Adherens junction | WASF3;INSR;CTNND1;CSNK2B;RHOA;PTPRB;EP300;FGFR1A;FYNA |
| Toll-like receptor signaling pathway | PIK3R3;CD86;TLR3;TLR7;IFNA8;MAP3K7;MAPK1;CD80;Ifna11 |
| Natural killer cell mediated cytotoxicity | KLRD1;KIR3DL1;IFNAR1;CD244;PIK3R1;KLRC2;PPP3CC;Ifna15;NCR2 |
| B cell receptor signaling pathway | LIME1;CD79B;ACTR2;KRAS;SOS1;VAV2;CTNNB2;TTC6;MAPK1 |
| Fc epsilon RI signaling pathway | LCP2;VAV3;IL3;LYN;SOS1;PIK3R2;LAT;SYK;MAP2K6 |
| Fc gamma R-mediated phagocytosis | PRKCA;LAT;ASAP2;PIK3CA;GAB2;PIP5K1A;MARCKSL1;PIK3R3;FCGR2A |
| Leukocyte transendothelial migration | PRKCG;CLDN16;RAC2;PTK2B;RAC1;CYBB;PECAM1;CLDN10;PIK3R1 |
| Neurotrophin signaling pathway | MAP3K1;IRAK4;PRKCD;SH2B2;NTF3;FOXO3;PRDM4;MAPK13;BAD |
| Regulation of actin cytoskeleton | TMSB4X;PFN2;ARHGEF7B;PIP5K2;DIAP1;MYL9B;CDC42L2;ITGAL;MYLK |
| Non-alcoholic fatty liver disease (NAFLD) | SDHA;ITCH;PRKAA2;AKT1;IL1B;TNFRSF1A;NDUFC1;NFKB1;ATF4 |
| Pancreatic secretion | PLCB1;AMY2A4;CLCA2;RAB27B;KCNQ1;CTRB1;CPB2;RYR2;AMY2B |
| Amyotrophic lateral sclerosis (ALS) | GPX1;BAX;GRIN2B;GRIN1;TRP53;MAPK13;GRIN2D;GRIA2;SLC1A2 |
| Bacterial invasion of epithelial cells | ELMO3;BCAR1;ARPC4;MAD2L2;PIK3R2;ARPC5L;ARPC2;DNM1;CAV3 |
| Epithelial cell signaling in Helicobacter pylori infection | CDC42;TCIRG1;ATP6V1E1;TJP1;ATP6V1B1;CXCL1;ATP6V1C2;IL-8;CXCR1 |
| Shigellosis | IL-8;ACTB;ROCK2;NFKBIA;DIAPH1;MAPK10;PFN4;PFN3;ITGB1 |
| Salmonella infection | TLR5;DYNC1LI1;TLR4BB;RAC1B;KLC4;RILP;IL-8;CD14;TLR4BA |
| Pathways in cancer | PRKACA;GLI3;CUL2;LAMC2;WNT5B;BIRC5;SLC2A1;FASLG;MAPK9 |
| Viral carcinogenesis | LYN;DLG1;HIST1H2BN;H2BFWT;HIST1H2BP;HIST1H2BB;HIST1H4H;HDAC3;HIST1H2BJ |
| Proteoglycans in cancer | PTPN11;WNT8B;DROSHA;PIK3CB;FGFR1;MSN;IGF1;CAMK2B;ITGB5 |
| Colorectal cancer | PIK3R1;RALGDS;TCF7;SMAD4;MLH1;AXIN1;GSK3B;TGFB2;AXIN2 |
| Renal cell carcinoma | PDGFB;HGF;PIK3R5;NRAS;VEGFA;CDC42;SLC2A1;PIK3CG;TGFB2 |
| Pancreatic cancer | RELA;BAD;KRAS;PIK3R2;TGFBR2;PIK3CB;MAPK9;BCL2L1;CDC42 |
| Choline metabolism in cancer | PIP5K1B;PDPK1;PLCG1;MAPK3;DGKQ;AKT2;SLC44A2;RAC3;PPAP2A |
| Viral myocarditis | HLA-DRB5;H2-Q10;SGCD;PRF1;CD28;ACTB;RAC2;SGCB;HLA-DRA |
RAC1 has several biochemical functions, for example, GTP binding, GTPase activity, Rho GDP-dissociation inhibitor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RAC1 itself. We selected most functions RAC1 had, and list some proteins which have the same functions with RAC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTP binding | INSR;SUCLG2;RABL2;TUBA1L2;PCK1;TUBA3D;EEF1A1L1;GNAQ;EEFSEC |
| GTPase activity | RAB11BA;RAB8B;RAB3AA;RAB17;EEF1A1L1;RAB44;MXG;RAB2A;GFM1 |
| Rho GDP-dissociation inhibitor binding | RAC1;RHOA |
| enzyme binding | HIST1H2AG;SLC27A2;MDM4;CBX3;POR;TH;YWHAE;LYN;GSTM3 |
| protein binding | ROS1;PEX11A;RUVBL2;RSG1;INTS5;PTTG1;PHF21A;TFDP1;DNAJC28 |
| thioesterase binding | ADRA2A;RAC1;TRAF2;CALM3;TRAF4;TRAF3;CALM;TRAF1;ARF6 |
RAC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAC1.
PAK1
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, there are clinical trials investigating the efficacy of RAC1-targeted therapies in various diseases, including cancer and inflammatory disorders.
RAC1 activation is implicated in the development of diabetic complications, particularly in the context of vascular dysfunction and diabetic nephropathy.
Research suggests that altered RAC1 expression and activity may serve as a biomarker for certain neurodegenerative diseases.
RAC1 is crucial for neurite outgrowth and synaptic plasticity, and its dysregulation has been implicated in neurological disorders, suggesting a potential target for therapeutic interventions.
RAC1 is involved in vascular smooth muscle cell migration, and its dysregulation is associated with cardiovascular diseases. Targeting RAC1 may offer therapeutic benefits in such cases.
Customer Reviews (3)
Write a reviewRAC1 protein is highly recommended for researchers and scientists due to its exceptional performance in ELISA assays.
Its reliability in ELISA makes it a trusted tool for quantitative and qualitative protein analysis.
With its superior binding affinity and specificity, RAC1 protein enables accurate and reliable detection of target analytes in various biological samples.
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