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RB1

  • Official Full Name

    retinoblastoma 1

  • Overview

    The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]
  • Synonyms

    RB1; retinoblastoma 1; RB; pRb; OSRC; pp110; p105-Rb; retinoblastoma-associated protein; retinoblastoma suspectibility protein; prepro-retinoblastoma-associated protein;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • Insect Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • N/A
  • N
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RB1-1192H Active Recombinant Human Retinoblastoma 1 Sf9 Insect Cell N/A
Human RB1-2509H Active Recombinant Human Retinoblastoma 1, His-tagged Insect Cell His
Human RB1-195H Recombinant Human RB1 protein E.coli N/A 146
Human RB1-570H Recombinant Human RB1, GST-tagged E.coli GST
Human RB1-701H Recombinant Human RB1, GST-tagged E.coli GST
Human RB1-651H Recombinant Human RB1 E.coli N/A
Human RB1-31044TH Recombinant Human RB1, His-tagged E.coli His
Human RB1-2197H Recombinant Human RB1, GST-tagged E.coli GST 576-928aa
Human RB1-173H Recombinant Human RB1 protein, T7/His-tagged E.coli T7/His
Human RB1-654H Recombinant Human RB1 protein, His-tagged E.coli His Ile753-Lys928
Human RB1-902H Recombinant Human RB1 protein, His-GST-tagged E.coli His/GST Gln639-Thr778
Human RB1-0401H Recombinant Human RB1 protein, His-tagged E.coli His 576-928 aa
Human RB1-382H Recombinant Human RB1 Protein, GST-tagged Wheat Germ GST 371-470 a.a.
Human RB1-6150H Recombinant Human RB1 Protein (Gln639-Thr778), N-GST tagged E.coli N-GST Gln639-Thr778
Rat RB1-4949R Recombinant Rat RB1 Protein Mammalian Cell His
Rat RB1-4608R-B Recombinant Rat RB1 Protein Pre-coupled Magnetic Beads HEK293
Rat RB1-4608R Recombinant Rat RB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat RB1-1283R Recombinant Rat NSF Protein (721-919 aa), His-tagged E.coli His 721-919 aa
Rhesus Macaque RB1-3801R Recombinant Rhesus monkey RB1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque RB1-3618R-B Recombinant Rhesus Macaque RB1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque RB1-3618R Recombinant Rhesus Macaque RB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish RB1-4856Z Recombinant Zebrafish RB1 Mammalian Cell His
Chicken RB1-5989C Recombinant Chicken RB1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • RB1 Related Articles
  • RB1 Related Gene Family
  • RB1 Related Research Area

RB1 involved in several pathways and played different roles in them. We selected most pathways RB1 participated on our site, such as Cell cycle, Hepatitis B, HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with RB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell cycleSKA1;SMARCA5;MCM3;TUBG1;CCNA2;CENPW;RBBP8;GADD45BB;CDCA8
Hepatitis BCasp3;IFIH1;HBXIP;TGFB2;MAVS;GRB2;IKBKG;EGR2;PIK3CA
HTLV-I infectionSTAT5A;CDC26;CREM;TBPL1;HLA-DMA;VCAM1;HLA-DRB3;ELK4;RRAS2
Epstein-Barr virus infectionIL10RB;MAPK8;RAN;HDAC5;MAPK10;HLA-B;PIK3R1;TRP53;PSMD11
Pathways in cancerGNG11;EGLN1;RALBP1;NRAS;FGF6;RBX1;RUNX1T1;GRB2;FGF1
Viral carcinogenesisHIST1H2BK;UBE3A;HDAC10;HIST1H2BA;HIST1H2BC;HIST1H2BB;EGR3;TBPL1;RANBP1
Pancreatic cancerPIK3CA;PIK3R1;MAPK9;BCL2L1;RALBP1;CCND1;MAPK10;TGFB2;IKBKB
GliomaCALML5;MAPK3;PIK3R3;PDGFB;AKT1;SOS1;MAPK1;MAP2K1;IGF1R
Prostate cancerPDGFD;PIK3R1;NDRG1;AKT1;SOS1;MAP4K1;CCNE1;SMARCD1;MDM2
MelanomaBAD;PIK3CB;FGF19;PIK3R1;FGF17;CCND1;FGF22;ARAF;FGF10
Bladder cancerDAPK3;VEGFA;KRAS;DAPK1;CDKN2A;DAPK2;RAF1;NRAS;RASSF1
Chronic myeloid leukemiaCTBP1;SHC4;RUNX1;GRB2;TRP53;RB1;PIK3R2;KRAS;TP53
Small cell lung cancerPIAS2;PIK3CG;ITGA3;TRAF1;LAMA5;NOS2;PIK3CA;MAX;NFKBIA
Non-small cell lung cancerMAPK1;TP53;PRKCG;PRKCB;RARB;PIK3R2;AKT1;MAP2K1;ARAF

RB1 has several biochemical functions, for example, DNA binding, RNA polymerase II activating transcription factor binding, androgen receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RB1 itself. We selected most functions RB1 had, and list some proteins which have the same functions with RB1. You can find most of the proteins on our site.

Function Related Protein
DNA bindingHIST1H2B8;TMPOA;SYCP2;ZFP335;HIST1H2BO;ZNF254;POLR1D;ZFP553;ZNF136
RNA polymerase II activating transcription factor bindingHNF4A;TBX6;NHLH2;CTNNB1;JUN;RB1;NEUROD1;HEY2;NCOR1
androgen receptor bindingWIPI1;RAN;CALR;TCF21;DAXX;KAT5;PRPF6;RNF4;NCOA1
core promoter bindingELK1;PSPC1;HDAC1;RBMX;E2F3;FOXO3;SFPQ;E2F7;NKX2-1
identical protein bindingMTPAP;BCL2L1;P2RX6;TPCN2;S100A1;PARK2;NDE1;HJURP;AHCY
kinase bindingPPP2R5A;SLC2A1;DUSP12;SRC;SP100;MIDN;C2orf44;PARP16;JAKMIP2
phosphoprotein bindingTHRAP3;TRPV1;CACNB2;RB1;PITX2;PRKCSH;TBK1;SRC;DPYS
protein bindingPIGS;SCAMP1;FAT4;CTDNEP1;PPM1F;PKP2;TBC1D17;MAGI2;FBXO45
transcription coactivator activitySERTAD2;VGLL2;TAF7L;MNT;CREBBP;NR1H3;SUPT3H;TBPL1;WNT3A
transcription factor activity, sequence-specific DNA bindingL3MBTL4;MEF2C;FOXJ1A;EGR2B;MYCLB;MSC;MESP1;ZFP287;HNF4G
transcription factor bindingUBN1;SIRT1;DNMT1;H2-AB1;MED12;MLXIPL;MED25;GNPTAB;TBX5
ubiquitin protein ligase bindingBECN1;AXIN1;MC4R;CUL3B;KDM4A;STUB1;GPR37;PRKACB;PRR5L

RB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RB1.

E7

Alvarenga, RFR; Friesen, JB; et al. K-Targeted Metabolomic Analysis Extends Chemical Subtraction to DESIGNER Extracts: Selective Depletion of Extracts of Hops (Humulus lupulus). JOURNAL OF NATURAL PRODUCTS 77:2595-2604(2014).
Chen, JY; Wu, HX; et al. Ginsenoside Metabolite Compound K Alleviates Adjuvant-Induced Arthritis by Suppressing T Cell Activation. INFLAMMATION 37:1608-1615(2014).
  • Q&As
  • Reviews

Q&As (7)

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What is the impact of RB1 mutations on the development of retinoblastoma and other cancers? 02/14/2022

Mutations in RB1 lead to retinoblastoma and increase the risk of other cancers, disrupting normal cell cycle control.

How does RB1 interact with transcription factors and affect gene expression? 10/30/2021

RB1 interacts with transcription factors to regulate gene expression, impacting various cellular processes.

What role does RB1 play in DNA damage response and repair mechanisms? 02/25/2021

RB1 plays a crucial role in the DNA damage response, facilitating repair and maintaining genomic stability.

How does RB1 regulate the cell cycle, particularly the transition from G1 to S phase? 04/09/2020

RB1 controls the G1 to S phase transition in the cell cycle, preventing unregulated cell division.

How do alterations in RB1 expression or function influence stem cell differentiation and tissue regeneration? 10/25/2019

Changes in RB1 function affect stem cell differentiation and tissue regeneration, influencing tissue maintenance and repair.

What are the mechanisms by which RB1 modulates cellular senescence and apoptosis? 09/03/2019

RB1 influences cellular senescence and apoptosis, playing a role in aging and cell turnover.

How does RB1 contribute to tumor suppression and the prevention of uncontrolled cell proliferation? 02/17/2019

As a tumor suppressor, RB1 prevents excessive cell proliferation and contributes to cancer prevention.

Customer Reviews (3)

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Reviews
07/15/2022

    Efficient protein purification, delivers consistent yield and purity.

    01/19/2021

      Expertise in protein engineering, a trusted resource for research.

      10/09/2019

        Reliable protein crystallization services, exceptional results achieved.

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