RB1
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Official Full Name
retinoblastoma 1
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Overview
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008] -
Synonyms
RB1; retinoblastoma 1; RB; pRb; OSRC; pp110; p105-Rb; retinoblastoma-associated protein; retinoblastoma suspectibility protein; prepro-retinoblastoma-associated protein;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- Insect Cell
- Mammalian Cell
- Sf9 Insect Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|GST
- N/A
- N
- T7|His
- Involved Pathway
- Protein Function
- Interacting Protein
- RB1 Related Articles
- RB1 Related Gene Family
- RB1 Related Research Area
RB1 involved in several pathways and played different roles in them. We selected most pathways RB1 participated on our site, such as Cell cycle, Hepatitis B, HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with RB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cell cycle | SKA1;SMARCA5;MCM3;TUBG1;CCNA2;CENPW;RBBP8;GADD45BB;CDCA8 |
Hepatitis B | Casp3;IFIH1;HBXIP;TGFB2;MAVS;GRB2;IKBKG;EGR2;PIK3CA |
HTLV-I infection | STAT5A;CDC26;CREM;TBPL1;HLA-DMA;VCAM1;HLA-DRB3;ELK4;RRAS2 |
Epstein-Barr virus infection | IL10RB;MAPK8;RAN;HDAC5;MAPK10;HLA-B;PIK3R1;TRP53;PSMD11 |
Pathways in cancer | GNG11;EGLN1;RALBP1;NRAS;FGF6;RBX1;RUNX1T1;GRB2;FGF1 |
Viral carcinogenesis | HIST1H2BK;UBE3A;HDAC10;HIST1H2BA;HIST1H2BC;HIST1H2BB;EGR3;TBPL1;RANBP1 |
Pancreatic cancer | PIK3CA;PIK3R1;MAPK9;BCL2L1;RALBP1;CCND1;MAPK10;TGFB2;IKBKB |
Glioma | CALML5;MAPK3;PIK3R3;PDGFB;AKT1;SOS1;MAPK1;MAP2K1;IGF1R |
Prostate cancer | PDGFD;PIK3R1;NDRG1;AKT1;SOS1;MAP4K1;CCNE1;SMARCD1;MDM2 |
Melanoma | BAD;PIK3CB;FGF19;PIK3R1;FGF17;CCND1;FGF22;ARAF;FGF10 |
Bladder cancer | DAPK3;VEGFA;KRAS;DAPK1;CDKN2A;DAPK2;RAF1;NRAS;RASSF1 |
Chronic myeloid leukemia | CTBP1;SHC4;RUNX1;GRB2;TRP53;RB1;PIK3R2;KRAS;TP53 |
Small cell lung cancer | PIAS2;PIK3CG;ITGA3;TRAF1;LAMA5;NOS2;PIK3CA;MAX;NFKBIA |
Non-small cell lung cancer | MAPK1;TP53;PRKCG;PRKCB;RARB;PIK3R2;AKT1;MAP2K1;ARAF |
RB1 has several biochemical functions, for example, DNA binding, RNA polymerase II activating transcription factor binding, androgen receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RB1 itself. We selected most functions RB1 had, and list some proteins which have the same functions with RB1. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | HIST1H2B8;TMPOA;SYCP2;ZFP335;HIST1H2BO;ZNF254;POLR1D;ZFP553;ZNF136 |
RNA polymerase II activating transcription factor binding | HNF4A;TBX6;NHLH2;CTNNB1;JUN;RB1;NEUROD1;HEY2;NCOR1 |
androgen receptor binding | WIPI1;RAN;CALR;TCF21;DAXX;KAT5;PRPF6;RNF4;NCOA1 |
core promoter binding | ELK1;PSPC1;HDAC1;RBMX;E2F3;FOXO3;SFPQ;E2F7;NKX2-1 |
identical protein binding | MTPAP;BCL2L1;P2RX6;TPCN2;S100A1;PARK2;NDE1;HJURP;AHCY |
kinase binding | PPP2R5A;SLC2A1;DUSP12;SRC;SP100;MIDN;C2orf44;PARP16;JAKMIP2 |
phosphoprotein binding | THRAP3;TRPV1;CACNB2;RB1;PITX2;PRKCSH;TBK1;SRC;DPYS |
protein binding | PIGS;SCAMP1;FAT4;CTDNEP1;PPM1F;PKP2;TBC1D17;MAGI2;FBXO45 |
transcription coactivator activity | SERTAD2;VGLL2;TAF7L;MNT;CREBBP;NR1H3;SUPT3H;TBPL1;WNT3A |
transcription factor activity, sequence-specific DNA binding | L3MBTL4;MEF2C;FOXJ1A;EGR2B;MYCLB;MSC;MESP1;ZFP287;HNF4G |
transcription factor binding | UBN1;SIRT1;DNMT1;H2-AB1;MED12;MLXIPL;MED25;GNPTAB;TBX5 |
ubiquitin protein ligase binding | BECN1;AXIN1;MC4R;CUL3B;KDM4A;STUB1;GPR37;PRKACB;PRR5L |
RB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RB1.
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- Q&As
- Reviews
Q&As (7)
Ask a questionMutations in RB1 lead to retinoblastoma and increase the risk of other cancers, disrupting normal cell cycle control.
RB1 interacts with transcription factors to regulate gene expression, impacting various cellular processes.
RB1 plays a crucial role in the DNA damage response, facilitating repair and maintaining genomic stability.
RB1 controls the G1 to S phase transition in the cell cycle, preventing unregulated cell division.
Changes in RB1 function affect stem cell differentiation and tissue regeneration, influencing tissue maintenance and repair.
RB1 influences cellular senescence and apoptosis, playing a role in aging and cell turnover.
As a tumor suppressor, RB1 prevents excessive cell proliferation and contributes to cancer prevention.
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