RCC1
-
Official Full Name
regulator of chromosome condensation 1
-
Overview
The Regulator of Chromosome Condensation 1 (RCC1) is a critical cell cycle regulator. This protein is involved in regulating the onset of chromosome condensation during S phase. The RCC1 protein binds to chromatin and interacts with Ran, a nuclear GTP-binding protein. This complex acts as a guanine-nucleotide dissociation stimulator (GDS) by promoting the loss of bound GDP and the uptake of fresh GTP. -
Synonyms
RCC1; regulator of chromosome condensation 1; CHC1, chromosome condensation 1; regulator of chromosome condensation; cell cycle regulatory protein; SNHG3-RCC1 readthrough transcript; guanine nucleotide-releasing protein; CHC1; RCC1-I; SNHG3-RCC1; rcc1-a; CHC 1; Chromosome condensation 1; Chromosome condensation protein 1; Guanine nucleotide releasing protein; HERC2; Ran GEF; RanGEF; RCC 1; RCC1 I; RCC1_HUMAN; SHEP1; SNHG3 RCC1; SNHG3 RCC1 readthrough transcript; xrcc1; chc1-a;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Zebrafish
- E. coli
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- N/A
- Strep
- Involved Pathway
- Protein Function
- Interacting Protein
- RCC1 Related Articles
RCC1 involved in several pathways and played different roles in them. We selected most pathways RCC1 participated on our site, such as Disease, HIV Infection, HIV Life Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with RCC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Disease | TH1L;HEY2;gag;CYP11A1;CHMP4B;RPL35;OPN1MW;EEF2;AP1B1 |
| HIV Infection | DOCK2;VPS37A;TAF1L;NMT1;PSIP1;NMT2;PACS1;ELL;AP1B1 |
| HIV Life Cycle | CHMP4B;ELL;PSTPIP2;RCC1;VPS37A;SSRP1;TCEB3;CDK9;TAF1L |
| Host Interactions of HIV factors | RCC1;AP1M2;PACS1;DOCK2;AP1S1;PSIP1;PPIAL4A;AP1G1;AP1B1 |
| Infectious disease | CHMP4C;NMT2;ANTXR1;STX1B;KPNA4;ANTXR2;PACS1;KPNA3;RCC1 |
| Interactions of Rev with host cellular proteins | |
| Late Phase of HIV Life Cycle | TAF1L;RCC1;NMT2;PDCD6IP |
| Nuclear import of Rev protein |
RCC1 has several biochemical functions, for example, Ran guanyl-nucleotide exchange factor activity, chromatin binding, histone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RCC1 itself. We selected most functions RCC1 had, and list some proteins which have the same functions with RCC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Ran guanyl-nucleotide exchange factor activity | ALS2;SERGEF;RCC1;RCBTB2;RANGRF;RANBP10 |
| chromatin binding | PAX3;TLE1;BAP1;L3MBTL1;ATRX;CDC45;JUB;ZFP932;CHD7 |
| histone binding | JAK2;HIST1H4C;RBBP4;HIST1H3F;SFMBT1;CTSL2;UHRF2;ASF1B;APBB1 |
| nucleosomal DNA binding | H3F3C;HMGN5;H3F3A;H1FOO;RCC1;HNRNPC;NSBP1;H2AFZ;HMGA2 |
| protein binding | ATP1A2;VPS26A;EPS8L1;MRPS12;RAB2A;UBE3C;MUC7;ALKBH3;KCNE1 |
RCC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RCC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RCC1.
RAN; gdp; Ranbp2; VCAM1; RANBP3; CSNK1A1; gtp
- Q&As
- Reviews
Q&As (6)
Ask a questionThe expression level of RCC1 protein may be related to the stage and clinicopathological features of lung cancer.
RCC1 protein is involved in regulating the progress of cellular mitosis by regulating the formation of new nuclear pores, the decomposition of nuclear membranes, and the separation of chromosomes.
RCC1 protein has some potential in tumor markers, but more research is needed to verify its clinical application value.
Yes, the RCC1 protein may play an important role in DNA damage repair, helping to maintain genome stability.
Mutations in the RCC1 protein are associated with neurological diseases (such as Parkinson's disease) and autoimmune diseases (such as systemic lupus erythematosus).
The RCC1 protein may be involved in the initiation and progression of immune diseases by affecting the activity of immune cells and the balance of immune responses.
Customer Reviews (3)
Write a reviewStability of tRCC1 is highly praised, and its ability to maintain its structural and functional stability even in various extreme environments is truly impressive.
The green production process of RCC1 focuses on sustainable development and maximizes the utilization of energy and resources by optimizing the production process and equipment.
This short half-life and high clearance properties of this RCC1 allow its rapid action and rapid clearance in vivo, reducing the risk of side effects.
Ask a Question for All RCC1 Products
Required fields are marked with *
My Review for All RCC1 Products
Required fields are marked with *
