Recombinant Human SLC1A2 Protein, GST-tagged

• Cat.No.: SLC1A2-22H
• Product Overview: Recombinant Human SLC1A2 Protein is produced by Wheat Germ (in vitro) expression system. This protein is fused with a GST tag at the N-terminal.

Specification

• Description: This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that
  clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced
  transcript variants of this gene have been described, but their full-length nature is not known.
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Form: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
• Molecular Mass: 88.5 kDa
• Protein length: 1-574 a.a.
• AA Sequence: MASTEGANNMPKQVEVRMHDSHLGS EEPKHRHLGLRLCDKLGKNLLLTLT VFGVILGAVCGGLLRLASPIHPDVV MLIAFPGDILMRMLKMLILPLIISS LITGLSGLDAKASGRLGTRAMVYYM STTIIAAVLGVILVLAIHPGNPKLK KQLGPGKKNDEVSSLDAFLDLIRNL FPENLVQACFQQIQTVTKKVLVAPP PDEEANATSAVVSLLNETVTEVPEE TKMVIKKGLEFKDGMNVLGLIGFFI AFGIAMGKMGDQAKLMVDFFNILNE IVMKLVIMIMWYSPLGIACLICGKI IAIKDLEVVARQLGMYMVTVIIGLI IHGGIFLPLIYFVVTRKNPFSFFAG IFQAWITALGTASSAGTLPVTFRCL EENLGIDKRVTRFVLPVGATINMDG TALYEAVAAIFIAQMNGVVLDGGQI VTVSLTATLASVGAASIPSAGLVTM LLILTAVGLPTEDISLLVAVDWLLD RMRTSVNVVGDSFGAGIVYHLSKSE LDTIDSQHRVHEDIEMTKTQSIYDD MKNHRESNSNQCVYAAHNSVIVDEC KVTLAANGKSADCSVEEEPWKREK
• Applications: Enzyme-linked Immunoabsorbent Assay;
  Western Blot (Recombinant protein);
  Antibody Production;
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.

Gene Information

• Gene Name: SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 [ Homo sapiens ]
• Official Symbol: SLC1A2
• Synonyms: SLC1A2; excitatory amino acid transporter 2; EAAT2; GLT 1; glutamate/aspartate transporter II; excitotoxic amino acid transporter 2; GLT-1
• Gene ID: 6506
• mRNA Refseq: NM_001195728
• Protein Refseq: NP_001182657
• MIM: 600300
• UniProt ID: P43004