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  • Official Full Name

    suppressor of cytokine signaling 1

  • Overview

    This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]
  • Synonyms

    SOCS1; suppressor of cytokine signaling 1; JAB; CIS1; SSI1; TIP3; CISH1; SSI-1; SOCS-1; TIP-3; JAK binding protein; JAK-binding protein; Tec-interacting protein 3; STAT induced SH3 protein 1; STAT-induced STAT inhibitor 1; cytokine-inducible SH2 protein 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Yeast
  • Flag
  • His
  • His (Fc)
  • Avi
  • His|Myc
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SOCS1-2870H Recombinant Human SOCS1 protein(1-211aa), His-tagged E. coli N-His 1-211aa
Human SOCS1-2590H Recombinant Human SOCS1 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human SOCS1-1582HCL Recombinant Human SOCS1 293 Cell Lysate HEK293 N/A
Human SOCS1-1525H Recombinant Human SOCS1 Protein (1-211 aa), His-tagged Yeast His 1-211 aa
Human SOCS1-895H Recombinant Human SOCS1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SOCS1-2067H Recombinant Human SOCS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SOCS1-568HFL Recombinant Full Length Human SOCS1 Protein, C-Flag-tagged Mammalian cells Flag
Human SOCS1-2067H-B Recombinant Human SOCS1 Protein Pre-coupled Magnetic Beads HEK293
Mouse SOCS1-2387M Recombinant Mouse SOCS1 Protein (1-212 aa), His-Myc-tagged E.coli His/Myc 1-212 aa
Mouse Socs1-893M Recombinant Mouse Socs1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat SOCS1-5663R Recombinant Rat SOCS1 Protein Mammalian Cell His
Rat SOCS1-5322R Recombinant Rat SOCS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SOCS1-5322R-B Recombinant Rat SOCS1 Protein Pre-coupled Magnetic Beads HEK293
Chicken SOCS1-3880C Recombinant Chicken SOCS1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SOCS1 Related Articles
  • SOCS1 Related Research Area
  • SOCS1 Related Signal Pathway

SOCS1 involved in several pathways and played different roles in them. We selected most pathways SOCS1 participated on our site, such as Ubiquitin mediated proteolysis, Osteoclast differentiation, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOCS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ubiquitin mediated proteolysisSMURF1;UBE2N;UBE2L3B;UBE3B;UBE2D3;SOCS1A;RCHY1;TRIM32;SAE1
Prolactin signaling pathwayPIK3R5;NRAS;GRB2;RELA;TNFRSF11A;CCND2;GSK3B;AKT2;CCND1
ToxoplasmosisGNAI1;MAPK10;Toxoplasma Gondii Dense Granule Protein 7;TYK2;BIRC7;GNAI2;BAD;GNAI3;HLA-DOA

SOCS1 has several biochemical functions, for example, insulin-like growth factor receptor binding, kinase inhibitor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SOCS1 itself. We selected most functions SOCS1 had, and list some proteins which have the same functions with SOCS1. You can find most of the proteins on our site.

Function Related Protein
insulin-like growth factor receptor bindingIGF3;YWHAH;YWHAG;SHC1;IGF1;SOCS2;INS;GNAS;IGF2B
kinase inhibitor activitySOCS1;LRP6;AHSG;RHOH
protein kinase bindingCDK5R1;CEP68;AKAP5;IFNAR2;RPS19;CACNB3;Cd24a;SHC4;TRAF3
protein kinase inhibitor activityCISHB;CAMK2N1A;SOCS1A;SOCS9;SH3BP5LA;SOCS1;WNK1;DNAJC3;SOCS6B

SOCS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOCS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOCS1.

TCEB1; COMMD1; PIK3R1; CRK; CRKL; ERBB2; MET; gag; RELA; JAK2; npm_alk

Sun, K; Salmon, S; et al. Expression of Suppressor of Cytokine Signaling 1 (SOCS1) Impairs Viral Clearance and Exacerbates Lung Injury during Influenza Infection. PLOS PATHOGENS 10:-(2014).
Disanto, G; Sandve, GK; et al. DNase hypersensitive sites and association with multiple sclerosis. HUMAN MOLECULAR GENETICS 23:942-948(2014).
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