SOCS1
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Official Full Name
suppressor of cytokine signaling 1
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Overview
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008] -
Synonyms
SOCS1; suppressor of cytokine signaling 1; JAB; CIS1; SSI1; TIP3; CISH1; SSI-1; SOCS-1; TIP-3; JAK binding protein; JAK-binding protein; Tec-interacting protein 3; STAT induced SH3 protein 1; STAT-induced STAT inhibitor 1; cytokine-inducible SH2 protein 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E. coli
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Yeast
- Flag
- His
- His (Fc)
- Avi
- His|Myc
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- SOCS1 Related Articles
- SOCS1 Related Research Area
- SOCS1 Related Signal Pathway
SOCS1 involved in several pathways and played different roles in them. We selected most pathways SOCS1 participated on our site, such as Ubiquitin mediated proteolysis, Osteoclast differentiation, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOCS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | SMURF1;UBE2N;UBE2L3B;UBE3B;UBE2D3;SOCS1A;RCHY1;TRIM32;SAE1 |
| Osteoclast differentiation | NFKB2;PPP3CB;PPP3R2;PLCG2;TNFRSF1A;NFKBIA;TGFB1;TGFB2;PIK3CD |
| Jak-STAT signaling pathway | CCND3;HRAS;AKT3A;IL6ST;PIK3CD;IL12A;SOCS1;IFNA4;GHR |
| Insulin signaling pathway | PPP1CAA;PPP1CBL;HRASA;HK3;PDPK1B;ACACA;PIK3R2;PCK1;EIF4E1B |
| Prolactin signaling pathway | PIK3R5;NRAS;GRB2;RELA;TNFRSF11A;CCND2;GSK3B;AKT2;CCND1 |
| Type II diabetes mellitus | HKDC1;SOCS1;MTOR;HK1;MAPK9;PIK3CB;PRKCE;IKBKB;PIK3R2 |
| Toxoplasmosis | GNAI1;MAPK10;Toxoplasma Gondii Dense Granule Protein 7;TYK2;BIRC7;GNAI2;BAD;GNAI3;HLA-DOA |
| MicroRNAs in cancer | EFNA3;PDGFRB;BCL2;DDIT4;RECK;MMP9;SPRY2;ERBB3;PRKCG |
SOCS1 has several biochemical functions, for example, insulin-like growth factor receptor binding, kinase inhibitor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SOCS1 itself. We selected most functions SOCS1 had, and list some proteins which have the same functions with SOCS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| insulin-like growth factor receptor binding | IGF3;YWHAH;YWHAG;SHC1;IGF1;SOCS2;INS;GNAS;IGF2B |
| kinase inhibitor activity | SOCS1;LRP6;AHSG;RHOH |
| protein binding | ST8SIA5;KRT79;FSHB;ITGA5;EIF2B5;TP53INP1;PRADC1;SRSF3;GOLSYN |
| protein kinase binding | CDK5R1;CEP68;AKAP5;IFNAR2;RPS19;CACNB3;Cd24a;SHC4;TRAF3 |
| protein kinase inhibitor activity | CISHB;CAMK2N1A;SOCS1A;SOCS9;SH3BP5LA;SOCS1;WNK1;DNAJC3;SOCS6B |
SOCS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOCS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOCS1.
TCEB1; COMMD1; PIK3R1; CRK; CRKL; ERBB2; MET; gag; RELA; JAK2; npm_alk
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