Recombinant Human SOCS1 Protein (1-211 aa), His-tagged

• Cat.No.: SOCS1-1525H
• Product Overview: Recombinant Human SOCS1 Protein (1-211 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Immunology. Protein Description: Full Length.

Specification

• Description: SOCS family proteins form part of a classical negative feedback syst that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival . Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Ses to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.
• Source: Yeast
• Species: Human
• Tag: His
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 25.6 kDa
• Protein length: 1-211 aa
• AA Sequence: MVAHNQVAADNAVSTAAEPRRRPEP SSSSSSSPAAPARPRPCPAVPAPAP GDTHFRTFRSHADYRRITRASALLD ACGFYWGPLSVHGAHERLRAEPVGT FLVRDSRQRNCFFALSVKMASGPTS IRVHFQAGRFHLDGSRESFDCLFEL LEHYVAAPRRMLGAPLRQRRVRPLQ ELCRQRIVATVGRENLARIPLNPVL RDYLSSFPFQI
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with reconstitution instruction is sent along with the products.

Gene Information

• Gene Name: SOCS1 suppressor of cytokine signaling 1 [ Homo sapiens ]
• Official Symbol: SOCS1
• Synonyms: SOCS1; Cish1; JAB; SOCS 1; SSI 1; TIP3; TIP-3; CIS1; SSI1; CISH1; SSI-1; SOCS-1
• Gene ID: 8651
• mRNA Refseq: NM_003745
• Protein Refseq: NP_003736
• MIM: 603597
• UniProt ID: O15524