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Recombinant Human SOCS1 Protein (1-211 aa), His-tagged

Cat.No. : SOCS1-1525H
Product Overview : Recombinant Human SOCS1 Protein (1-211 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Immunology. Protein Description: Full Length.
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Description : SOCS family proteins form part of a classical negative feedback syst that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival . Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Ses to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.
Source : Yeast
Species : Human
Tag : His
Form : Tris-based buffer,50% glycerol
Molecular Mass : 25.6 kDa
Protein length : 1-211 aa
AA Sequence : MVAHNQVAADNAVSTAAEPRRRPEP SSSSSSSPAAPARPRPCPAVPAPAP GDTHFRTFRSHADYRRITRASALLD ACGFYWGPLSVHGAHERLRAEPVGT FLVRDSRQRNCFFALSVKMASGPTS IRVHFQAGRFHLDGSRESFDCLFEL LEHYVAAPRRMLGAPLRQRRVRPLQ ELCRQRIVATVGRENLARIPLNPVL RDYLSSFPFQI
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with reconstitution instruction is sent along with the products.
Gene Name : SOCS1 suppressor of cytokine signaling 1 [ Homo sapiens ]
Official Symbol : SOCS1
Synonyms : SOCS1; Cish1; JAB; SOCS 1; SSI 1; TIP3; TIP-3; CIS1; SSI1; CISH1; SSI-1; SOCS-1;
Gene ID : 8651
mRNA Refseq : NM_003745
Protein Refseq : NP_003736
MIM : 603597
UniProt ID : O15524

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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