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Recombinant Human SOCS1 Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : SOCS1-895H
Product Overview : SOCS1 MS Standard C13 and N15-labeled recombinant protein (NP_003736) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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Description : This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 23.4 kDa
AA Sequence : MVAHNQVAADNAVSTAAEPRRRPEP SSSSSSSPAAPARPRPCPAVPAPAP GDTHFRTFRSHADYRRITRASALLD ACGFYWGPLSVHGAHERLRAEPVGT FLVRDSRQRNCFFALSVKMASGPTS IRVHFQAGRFHLDGSRESFDCLFEL LEHYVAAPRRMLGAPLRQRRVRPLQ ELCRQRIVATVGRENLARIPLNPVL RDYLSSFPFQITRTRPLEQKLISEE DLAANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : SOCS1 suppressor of cytokine signaling 1 [ Homo sapiens (human) ]
Official Symbol : SOCS1
Synonyms : SOCS1; suppressor of cytokine signaling 1; Cish1; JAB; SOCS 1; SSI 1; TIP3; TIP-3; JAK binding protein; JAK-binding protein; Tec-interacting protein 3; STAT induced SH3 protein 1; STAT-induced STAT inhibitor 1; cytokine-inducible SH2 protein 1; CIS1; SSI1; CISH1; SSI-1; SOCS-1;
Gene ID : 8651
mRNA Refseq : NM_003745
Protein Refseq : NP_003736
MIM : 603597
UniProt ID : O15524

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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