Recombinant Full Length Human SOCS1 Protein, C-Flag-tagged

• Cat.No.: SOCS1-568HFL
• Product Overview: Recombinant Full Length Human SOCS1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 23.4 kDa
• AA Sequence: MVAHNQVAADNAVSTAAEPRRRPEP SSSSSSSPAAPARPRPCPAVPAPAP GDTHFRTFRSHADYRRITRA SALLDACGFYWGPLSVHGAHERLRA EPVGTFLVRDSRQRNCFFALSVKMA SGPTSIRVHFQAGRFHLDGS RESFDCLFELLEHYVAAPRRMLGAP LRQRRVRPLQELCRQRIVATVGREN LARIPLNPVLRDYLSSFPFQ
  ITRTRPLEQKLISEEDLAANDILDY KDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Stem cell - Pluripotency, Stem cell relevant signaling - JAK/STAT signaling pathway
• Protein Pathways: Insulin signaling pathway, Jak-STAT signaling pathway, Type II diabetes mellitus, Ubiquitin mediated proteolysis

Gene Information

• Gene Name: SOCS1 suppressor of cytokine signaling 1 [ Homo sapiens (human) ]
• Official Symbol: SOCS1
• Synonyms: JAB; CIS1; SSI1; TIP3; CISH1; SSI-1; TIP-3; AISIMD; SOCS-1
• Gene ID: 8651
• mRNA Refseq: NM_003745.2
• Protein Refseq: NP_003736.1
• MIM: 603597
• UniProt ID: O15524