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Recombinant Full Length Human SOCS1 Protein, C-Flag-tagged

Cat.No. : SOCS1-568HFL
Product Overview : Recombinant Full Length Human SOCS1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.
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Description : This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.
Source : Mammalian cells
Species : Human
Tag : Flag
Form : 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 23.4 kDa
AA Sequence : MVAHNQVAADNAVSTAAEPRRRPEP SSSSSSSPAAPARPRPCPAVPAPAP GDTHFRTFRSHADYRRITRA SALLDACGFYWGPLSVHGAHERLRA EPVGTFLVRDSRQRNCFFALSVKMA SGPTSIRVHFQAGRFHLDGS RESFDCLFELLEHYVAAPRRMLGAP LRQRRVRPLQELCRQRIVATVGREN LARIPLNPVLRDYLSSFPFQ
ITRTRPLEQKLISEEDLAANDILDY KDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining.
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade.
Concentration : >50 ug/mL as determined by microplate BCA method.
Preparation : Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Protein Families : Druggable Genome, Stem cell - Pluripotency, Stem cell relevant signaling - JAK/STAT signaling pathway
Protein Pathways : Insulin signaling pathway, Jak-STAT signaling pathway, Type II diabetes mellitus, Ubiquitin mediated proteolysis
Gene Name : SOCS1 suppressor of cytokine signaling 1 [ Homo sapiens (human) ]
Official Symbol : SOCS1
Synonyms : JAB; CIS1; SSI1; TIP3; CISH1; SSI-1; TIP-3; AISIMD; SOCS-1
Gene ID : 8651
mRNA Refseq : NM_003745.2
Protein Refseq : NP_003736.1
MIM : 603597
UniProt ID : O15524

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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