Recombinant Mouse SOCS1 Protein (1-212 aa), His-Myc-tagged

• Cat.No.: SOCS1-2387M
• Product Overview: Recombinant Mouse SOCS1 Protein (1-212 aa) is produced by E. coli expression system. This protein is fused with a 10xHis tag at the N-terminal and a Myc tag at the C-terminal. Research: Area Immunology. Protein Description: Full Length.

Specification

• Description: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.
• Source: E. coli
• Species: Mouse
• Tag: His-Myc
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 28.7 kDa
• Protein length: 1-212 aa
• AA Sequence: MVARNQVAADNAISPAAEPRRRSEP SSSSSSSSPAAPVRPRPCPAVPAPA PGDTHFRTFRSHSDYRRITRTSALL DACGFYWGPLSVHGAHERLRAEPVG TFLVRDSRQRNCFFALSVKMASGPT SIRVHFQAGRFHLDGSRETFDCLFE LLEHYVAAPRRMLGAPLRQRRVRPL QELCRQRIVAAVGRENLARIPLNPV LRDYLSSFPFQI
• Purity: > 85% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA will be sent along with the products. Please refer to it for detailed information.

Gene Information

• Gene Name: Socs1 suppressor of cytokine signaling 1 [ Mus musculus ]
• Official Symbol: SOCS1
• Synonyms: SOCS1; JAK-binding protein; JAK2-binding protein; JAB; Cish1; Cish7; SSI-1; SOCS-1
• Gene ID: 12703
• mRNA Refseq: NM_009896
• Protein Refseq: NP_034026
• UniProt ID: O35716