Recombinant Mouse SOCS1 Protein (1-212 aa), His-Myc-tagged

Cat.No. : SOCS1-2387M
Product Overview : Recombinant Mouse SOCS1 Protein (1-212 aa) is produced by E. coli expression system. This protein is fused with a 10xHis tag at the N-terminal and a Myc tag at the C-terminal. Research: Area Immunology. Protein Description: Full Length.
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Description : SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.
Source : E. coli
Species : Mouse
Tag : His-Myc
Form : Tris-based buffer,50% glycerol
Molecular Mass : 28.7 kDa
Protein length : 1-212 aa
AA Sequence : MVARNQVAADNAISPAAEPRRRSEP SSSSSSSSPAAPVRPRPCPAVPAPA PGDTHFRTFRSHSDYRRITRTSALL DACGFYWGPLSVHGAHERLRAEPVG TFLVRDSRQRNCFFALSVKMASGPT SIRVHFQAGRFHLDGSRETFDCLFE LLEHYVAAPRRMLGAPLRQRRVRPL QELCRQRIVAAVGRENLARIPLNPV LRDYLSSFPFQI
Purity : > 85% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA will be sent along with the products. Please refer to it for detailed information.
FACS: (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Gene Name : Socs1 suppressor of cytokine signaling 1 [ Mus musculus ]
Official Symbol : SOCS1
Synonyms : SOCS1; JAK-binding protein; JAK2-binding protein; JAB; Cish1; Cish7; SSI-1; SOCS-1;
Gene ID : 12703
mRNA Refseq : NM_009896
Protein Refseq : NP_034026
UniProt ID : O35716

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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