spp1

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spp1

Official Full Name secreted phosphoprotein 1
Background The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Synonyms SPP1; secreted phosphoprotein 1; OPN; BNSP; BSPI; ETA-1; osteopontin; uropontin; nephropontin; SPP1/CALPHA1 fusion; urinary stone protein; early T-lymphocyte activation 1; osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein; secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1);
    • Species :
    • Chicken
    • Dog
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Rhesus monkey
    • Zebrafish
    • Source :
    • CHO
    • E. coli
    • E.coli
    • HEK293
    • HEK293F
    • HEK293T
    • Human
    • Human Cell
    • Mammalian Cell
    • NS0
    • NSO
    • Rabbit
    • Sf9 Insect Cell
    • Tag :
    • DDK
    • Fc
    • GST
    • His
    • MBP
    • Myc/DDK
    • Myc
    • N/A
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CAB11606RH Rabbit Monoclonal Antibody to Human Secreted Phosphoprotein 1 Rabbit N/A
    Human SPP1-001H Recombinant Human SPP1 Protein, MBP-tagged E.coli MBP
    Human SPP1-002H Recombinant Human SPP1 Protein, GST-tagged E.coli GST
    Human SPP1-004H Recombinant Human SPP1 Protein, His-tagged E.coli His
    Human SPP1-040H Recombinant Human SPP1 Protein, His-tagged E. coli His
    Human SPP1-120H Recombinant Human Secreted Phosphoprotein 1, HIgG1 Fc-tagged, mutant CHO Fc
    Human SPP1-121H Recombinant Human Secreted Phosphoprotein 1, MIgG2a Fc-tagged CHO Fc
    Human SPP1-122H Recombinant Human Secreted Phosphoprotein 1, HIgG1 Fc-tagged CHO Fc
    Human SPP1-2535HCL Recombinant Human SPP1 cell lysate Human Cell N/A
    Human SPP1-260H Recombinant Human SPP1, StrepII-tagged Human Cell Strep II
    Human SPP1-2680H Recombinant Human SPP1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human SPP1-28248TH Recombinant Human SPP1, MBP-tagged E.coli MBP
    Human SPP1-3044H Recombinant Human SPP1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human SPP1-30522TH Recombinant Human SPP1 N/A
    Human SPP1-314H Recombinant Human SPP1 Mammalian Cell His
    Human SPP1-336H Recombinant Human SPP1 protein, His-tagged HEK293 His
    Human SPP1-372H Recombinant Human Secreted Phosphoprotein 1, His-tagged E.coli His
    Human SPP1-4058H Recombinant Human SPP1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human SPP1-447H Recombinant Human SPP1 protein, His-tagged HEK293F His
    Human SPP1-5129H Recombinant Human Secreted Phosphoprotein 1, His-tagged Human His
    Human SPP1-5130H Recombinant Human Secreted Phosphoprotein 1 Human N/A
    Human SPP1-5246H Recombinant Human SPP1 Protein, GST-tagged E.coli GST
    Human SPP1-5435H Recombinant Human SPP1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human SPP1-570H Recombinant Human SPP1 protein, His-tagged E.coli His
    Human SPP1-616H Recombinant Human SPP1, His-tagged NS0 His
    Human SPP1-664H Recombinant Human SPP1, His tagged Human Cell His
    Human SPP1-705H Recombinant Human SPP1 Protein HEK293 N/A
    Human SPP1-706H Recombinant Human SPP1 Protein, DDK-tagged Sf9 Insect Cell DDK
    Human SPP1-815H Recombinant Human Secreted Phosphoprotein 1, GST-tagged E.coli GST
    Human SPP1-816H Recombinant Human Secreted Phosphoprotein 1, MBP-tagged E.coli MBP
    Mouse Spp1-1772M Recombinant Mouse Secreted Phosphoprotein 1 NSO N/A
    Mouse SPP1-465M Recombinant Mouse SPP1 protein, His-tagged HEK293F His
    Mouse Spp1-6106M Recombinant Mouse Spp1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat SPP1-5719R Recombinant Rat SPP1 Protein Mammalian Cell His
    Rat Spp1-571R Recombinant Rat Spp1 protein, His-tagged HEK293F His
    Rhesus Macaque SPP1-4444R Recombinant Rhesus monkey SPP1 Protein, His-tagged Mammalian Cell His
    Rhesus monkey SPP1-7902R Recombinant Rhesus monkey SPP1 protein, His-tagged E.coli His
    Dog SPP1-7901D Recombinant Dog SPP1 protein, His-tagged E.coli His
    Chicken SPP1-6104C Recombinant Chicken SPP1 Mammalian Cell His
    Zebrafish SPP1-457Z Recombinant Zebrafish SPP1 Mammalian Cell His

    spp1 involved in several pathways and played different roles in them. We selected most pathways spp1 participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with spp1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    PIK-Akt signaling pathway MAPK1; HGF; PPP2R5A; FOXO3; SYK; ANGPT1; FGF2; FGFR4; ITGB1; Gh
    Focal adhesion ITGA9; ITGA4; ERBB2; PTENB; ACTN3; ACTN3A; RAF1B; FN1; ITGA5; PAK1
    ECM-receptor interaction ITGB4; COL2A1A; GP5; ITGB3; COL11A2; ITGB1; IBSP; VWF; COL4A2; COL6A2
    Toll-like receptor signaling pathway IFNA17; CD86; IL-8; NFKBIA; IRAK4; MAP2K2B; TLR4BB; TOLLIP; NFKBIAB; TLR8

    spp1 has several biochemical functions, for example, cytokine activity, extracellular matrix binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by spp1 itself. We selected most functions spp1 had, and list some proteins which have the same functions with spp1. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity IFNA5; TNFSF8; BMP8B; IFNG1-1; GM13279; IFNA21; TGFB1; SP100; VEGFA; IFNPHI4
    extracellular matrix binding CYR61; DMP1; FBLN2; ITGAV; SPARC; VEGFA; SPOCK2; GPR56; ITGA2B; TGFBI
    protein binding EXOC1; TPD52L2; GP1BA; CUL9; TPT1; SCP2; PTPN12; FMNL1; FGF12; VBP1

    spp1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with spp1 here. Most of them are supplied by our site. Hope this information will be useful for your research of spp1.

    SGTA; CD44; MEOX2; UBQLN4; F2; APOA1; PEPD; BAG6; CTNNBL1; PDLIM7

    Shi, M; Movius, J; et al. Cerebrospinal Fluid Peptides as Potential Parkinson Disease Biomarkers: A Staged Pipeline for Discovery and Validation. MOLECULAR & CELLULAR PROTEOMICS 14:544-555(2015).
    Gazal, S; Sacre, K; et al. Identification of secreted phosphoprotein 1 gene as a new rheumatoid arthritis susceptibility gene. ANNALS OF THE RHEUMATIC DISEASES 74:-(2015).

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