TNC

  • Official Full Name

    tenascin C

  • Overview

    Tenascins are extracellular matrix glycoproteins. They are abundant in the extracellular matrix of developing vertebrate embryos and they reappear around healing wounds and in the stroma of some tumors.
  • Synonyms

    Tenascin-X; tenascin XB1; tenascin XB2; OTTHUMP00000174881; tenascin XB; OTTHUMP00000216549; hexabrachion-like protein; growth-inhibiting protein 45; XB; TNX; XBS; HXBL; TENX; TN-X; TNXB1; TNXB2; TNXBS; TNXB;

  • Recombinant Proteins
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rabbit
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human glioma cell line (U251)
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TNC-734H Active Recombinant Human TNC, His-tagged Mammalian cells His
Human TNC-32H Recombinant Human TNC Partial Protein, His-tagged E.coli His 1888-2201
Human TNC-31215TH Recombinant Human TNC Wheat Germ N/A 110 amino acids
Human TNC-301211H Recombinant Human TNC protein, GST-tagged E.coli GST Gly23-Cys200
Human TNC-08H Native Human TNC Protein Human glioma cell line (U251)
Human TNC-50H Native Human Tenascin C N/A
Human TNC-311H Recombinant Human Transthyretin (Wild Type) Protein, 13C, 15N Label E.coli N/A
Human TNC-995HFL Recombinant Full Length Human TNC Protein, C-Flag-tagged Mammalian cells Flag
Human TNC-33H Recombinant Human TNC protein, His-tagged E.coli His Val49~Lys181
Human TNC-2216H-B Recombinant Human TNC Protein Pre-coupled Magnetic Beads HEK293
Human TNC-1082H Recombinant Human TNC Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TNC-4224H-B Recombinant Human TNC Protein Pre-coupled Magnetic Beads HEK293
Human TNC-34H Recombinant Human TNC protein, His-tagged E.coli His Leu1262~Ser1566
Human TNC-2216H Recombinant Human TNC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TNC-4224H Recombinant Human TNC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TNC-735H Recombinant Human TNC protein(Gly23-Ser621), His-tagged HEK293 C-His Gly23-Ser621
Mouse Tnc-2051M Recombinant Mouse Tnc protein, His-tagged E.coli His Cys174~Ser621
Mouse TNC-2566M Recombinant Mouse TNC Protein (1884-2099 aa), His-tagged Yeast His 1884-2099 aa
Mouse Tnc-736M Recombinant Mouse Tnc protein(Gly23-Ser621), His-tagged HEK293 C-His Gly23-Ser621
Mouse Tnc-5115M Recombinant Mouse Tnc protein, His&Myc-tagged HEK293 His&Myc 1884-2099aa
Mouse Tnc-6538M Recombinant Mouse Tnc Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Tnc-2326M Recombinant Mouse Tnc protein, His&Myc-tagged Insect Cell His&Myc 1884-2099aa
Rat Tnc-2052R Recombinant Rat Tnc protein, His-tagged E.coli His Val175~Gly342 (Accession # B2LYI9)
Rabbit TNC-256R Recombinant Rabbit Cardiac Troponin C E.coli N/A
Zebrafish TNC-8548Z Recombinant Zebrafish TNC Mammalian Cell His
Chicken TNC-7006C Recombinant Chicken TNC Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

TNC involved in several pathways and played different roles in them. We selected most pathways TNC participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PIK-Akt signaling pathwayPGF;CREB3L2;PPP2R2D;GRB2;CREB5;IFNA8;TLR2;RPTOR;HSP90B1
Focal adhesionMAPK4;THBS1;MYL12A;PDGFRB;TNC;LAMA4;MAPK9;ACTB1;SRMS
ECM-receptor interactionITGA6;SDC1;GP9;COL11A2;COL4A1;ITGB1;ITGA2;VTN;ITGB7
MicroRNAs in cancerHDAC4;BRCA1;MAP2K2;ATM;VIM;EP300;HRAS;PLAU;TP53

TNC has several biochemical functions, for example, syndecan binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNC itself. We selected most functions TNC had, and list some proteins which have the same functions with TNC. You can find most of the proteins on our site.

Function Related Protein
syndecan bindingHPSE;TNC;SEMA5A;SDCBP;CHRD

TNC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNC here. Most of them are supplied by our site. Hope this information will be useful for your research of TNC.

Research Area

Related articles

Pezzolo, A; Marimpietri, D; et al. Failure of anti tumor-derived endothelial cell immunotherapy depends on augmentation of tumor hypoxia. ONCOTARGET 5:10368-10381(2014).
Alessio, GD; Cortes, DF; et al. Innovations in diagnosis and post-therapeutic monitoring of Chagas disease: Simultaneous flow cytometric detection of IgG1 antibodies anti-live amastigote, anti-live trypomastigote, and anti-fixed epimastigote forms of Trypanosoma cruzi. JOURNAL OF IMMUNOLOGICAL METHODS 413:32-44(2014).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
Is there an association between TNC protein and cardiovascular disease? 12/28/2019

Some studies have found that TNC protein plays a role in cardiovascular diseases such as atherosclerosis, myocardial infarction, etc., and may participate in pathophysiological processes.

Which role of TNC protein in the nervous system? 09/01/2019

TNC protein plays an important role in the development and repair of the nervous system, including neuronal migration, axon growth and synapse formation.

Are there an association between TNC protein and neurodegenerative diseases? 05/23/2019

Some studies have found that TNC protein is associated with neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, and may be involved in the occurrence and development of diseases.

Is there a relationship between the measurement of TNC protein and its function? 05/18/2019

TNC protein measurement can be used for cancer diagnosis and disease prognosis, but further studies are needed to confirm a direct link with TNC protein function.

What is the relationship between TNC protein and immune regulation? 02/18/2019

TNC protein plays a role in immune regulation, can regulate inflammatory response, promote the activation and migration of immune cells, etc.

What is the relationship between TNC protein and tissue repair? 02/18/2019

This protein plays an important role in tissue repair, can regulate cell migration, cell proliferation, and the formation of new blood vessels, and promote tissue repair.

Customer Reviews (3)

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Reviews
12/03/2020

    Using TNC, the lower limit of detection of Western blot was significantly reduced.

    12/30/2019

      The repeatability of TNC is very good, which can reduce the error in the experiment and improve the reproducibility of the experiment.

      09/19/2019

        TNC were labeled very well and could be used for fluorescent labeling, etc., which was very suitable for our study.

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