Recombinant Full Length Human TNC Protein, C-Flag-tagged

• Cat.No.: TNC-995HFL
• Product Overview: Recombinant Full Length Human TNC Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 238.6 kDa
• AA Sequence: MGAMTQLLAGVFLAFLALATEGGVL KKVIRHKRQSGVNATLPEENQPVVF NHVYNIKLPVGSQCSVDLES ASGEKDLAPPSEPSESFQEHTVDGE NQIVFTHRINIPRRACGCAAAPDVK ELLSRLEELENLVSSLREQC TAGAGCCLQPATGRLDTRPFCSGRG NFSTEGCGCVCEPGWKGPNCSEPEC PGNCHLRGRCIDGQCICDDG FTGEDCSQLACPSDCNDQGKCVNGV CICFEGYAGADCSREICPVPCSEEH GTCVDGLCVCHDGFAGDDCN KPLCLNNCYNRGRCVENECVCDEGF TGEDCSELICPNDCFDRGRCINGTC YCEEGFTGEDCGKPTCPHAC HTQGRCEEGQCVCDEGFAGVDCSEK RCPADCHNRGRCVDGRCECDDGFTG ADCGELKCPNGCSGHGRCVN GQCVCDEGYTGEDCSQLRCPNDCHS RGRCVEGKCVCEQGFKGYDCSDMSC PNDCHQHGRCVNGMCVCDDG YTGEDCRDRQCPRDCSNRGLCVDGQ CVCEDGFTGPDCAELSCPNDCHGRG RCVNGQCVCHEGFMGKDCKE QRCPSDCHGQGRCVDGQCICHEGFT GLDCGQHSCPSDCNNLGQCVSGRCI CNEGYSGEDCSEVSPPKDLV VTEVTEETVNLAWDNEMRVTEYLVV YTPTHEGGLEMQFRVPGDQTSTIIR ELEPGVEYFIRVFAILENKK SIPVSARVATYLPAPEGLKFKSIKE TSVEVEWDPLDIAFETWEIIFRNMN KEDEGEITKSLRRPETSYRQ TGLAPGQEYEISLHIVKNNTRGPGL KRVTTTRLDAPSQIEVKDVTDTTAL ITWFKPLAEIDGIELTYGIK DVPGDRTTIDLTEDENQYSIGNLKP DTEYEVSLISRRGDMSSNPAKETFT TGLDAPRNLRRVSQTDNSIT LEWRNGKAAIDSYRIKYAPISGGDH AEVDVPKSQQATTKTTLTGLRPGTE YGIGVSAVKEDKESNPATIN AATELDTPKDLQVSETAETSLTLLW KTPLAKFDRYRLNYSLPTGQWVGVQ LPRNTTSYVLRGLEPGQEYN VLLTAEKGRHKSKPARVKASTEQAP ELENLTVTEVGWDGLRLNWTAADQA YEHFIIQVQEANKVEAARNL TVPGSLRAVDIPGLKAATPYTVSIY GVIQGYRTPVLSAEASTGETPNLGE VVVAEVGWDALKLNWTAPEG AYEYFFIQVQEADTVEAAQNLTVPG GLRSTDLPGLKAATHYTITIRGVTQ DFSTTPLSVEVLTEEVPDMG NLTVTEVSWDALRLNWTTPDGTYDQ FTIQVQEADQVEEAHNLTVPGSLRS MEIPGLRAGTPYTVTLHGEV RGHSTRPLAVEVVTEDLPQLGDLAV SEVGWDGLRLNWTAADNAYEHFVIQ VQEVNKVEAAQNLTLPGSLR AVDIPGLEAATPYRVSIYGVIRGYR TPVLSAEASTAKEPEIGNLNVSDIT PESFNLSWMATDGIFETFTI EIIDSNRLLETVEYNISGAERTAHI SGLPPSTDFIVYLSGLAPSIRTKTI SATATTEALPLLENLTISDI NPYGFTVSWMASENAFDSFLVTVVD SGKLLDPQEFTLSGTQRKLELRGLI TGIGYEVMVSGFTQGHQTKP LRAEIVTEAEPEVDNLLVSDATPDG FRLSWTADEGVFDNFVLKIRDTKKQ SEPLEITLLAPERTRDLTGL REATEYEIELYGISKGRRSQTVSAI ATTAMGSPKEVIFSDITENSATVSW RAPTAQVESFRITYVPITGG TPSMVTVDGTKTQTRLVKLIPGVEY LVSIIAMKGFEESEPVSGSFTTALD GPSGLVTANITDSEALARWQ PAIATVDSYVISYTGEKVPEITRTV SGNTVEYALTDLEPATEYTLRIFAE KGPQKSSTITAKFTTDLDSP RDLTATEVQSETALLTWRPPRASVT GYLLVYESVDGTVKEVIVGPDTTSY SLADLSPSTHYTAKIQALNG PLRSNMIQTIFTTIGLLYPFPKDCS QAMLNGDTTSGLYTIYLNGDKAQAL EVFCDMTSDGGGWIVFLRRK NGRENFYQNWKAYAAGFGDRREEFW LGLDNLNKITAQGQYELRVDLRDHG ETAFAVYDKFSVGDAKTRYK LKVEGYSGTAGDSMAYHNGRSFSTF DKDTDSAITNCALSYKGAFWYRNCH RVNLMGRYGDNNHSQGVNWF
  HWKGHEHSIQFAEMKLRPSNFRNLE GRRKRATRTRPLEQKLISEEDLAAN DILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Transmembrane
• Protein Pathways: ECM-receptor interaction, Focal adhesion

Gene Information

• Gene Name: TNC tenascin C [ Homo sapiens (human) ]
• Official Symbol: TNC
• Synonyms: GP; JI; TN; HXB; GMEM; TN-C; DFNA56; 150-225
• Gene ID: 3371
• mRNA Refseq: NM_002160.4
• Protein Refseq: NP_002151.2
• MIM: 187380
• UniProt ID: P24821