TREM2

  • Official Full Name

    triggering receptor expressed on myeloid cells 2

  • Overview

    The protein encoded by this gene is a membrane protein that forms a receptor signaling complex with TYROBP. The encoded;protein may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines.;Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy;(PLOSL).
  • Synonyms

    TREM2; triggering receptor expressed on myeloid cells 2; triggering receptor expressed on myeloid cells 2a; TREM 2; Trem2a; Trem2b; Trem2c; triggering receptor expressed on monocytes 2; TREM-2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus
  • Human
  • Mouse
  • Rat
  • E. coli
  • E.coli
  • HEK293
  • HEK294
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • Mouse myeloma cell line
  • Yeast
  • C
  • Fc
  • His
  • Avi
  • GST
  • His (Fc)
  • Myc
  • His|GST
  • mFc
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TREM2-715H Active Recombinant Human TREM2 Protein, Fc Chimera Mammalian cells Fc
Human TREM2-283H Active Recombinant Human TREM2 Protein, Fc-tagged HEK293 Fc His 19-Ser 174
Human TREM2-3111H Active Recombinant Human TREM2 protein, His-tagged HEK293 His His 19 - Ser 174
Human TREM2-282H Active Recombinant Human TREM2 Protein, His-tagged Mouse myeloma cell line His
Human TREM2-2452H Recombinant human TREM2, His-tagged E.coli His
Human TREM2-2649HCL Recombinant Human TREM2 cell lysate Human Cell N/A
Human TREM2-1933H Recombinant Human TREM2 Protein (19-174 aa), His-tagged Yeast His 19-174 aa
Human TREM2-0792H Active Recombinant Human TREM2 protein, Fc-tagged HEK293 Fc His19-Asp131
Human TREM2-5927H Recombinant Human TREM2 Protein (His19-Arg161), N-His tagged E.coli N-His His19-Arg161
Human TREM2-310H Active Recombinant Human TREM2 protein(Met1-Ser174), His&Avi-tagged, Biotinylated HEK293 C-His&Avi Met1-Ser174
Human TREM2-092H Recombinant Human TREM2 protein, His-Avi-tagged HEK293 His-Avi His19-Ser174
Human TREM2-02H Recombinant Human TREM2 Protein, GST/His-tagged E. coli GST/His
Human TREM2-04H Recombinant Human TREM2 Protein (19-174aa), C-His-tagged HEK293 C-His 19-174aa
Human TREM2-486H Recombinant Human TREM2 Protein, His-tagged E.coli N-His His19-Ser174
Human TREM2-01H Active Recombinant Human TREM2 Protein, Fc/His-tagged HEK293 Fc/His
Human TREM2-30H Recombinant Human TREM2 Protein, Fc-tagged HEK294 Fc
Human TREM2-161H Recombinant Human TREM2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TREM2-1293H Recombinant Human TREM2 protein, His&Myc-tagged HEK293 His&Myc 19-174aa
Human TREM2-309H Active Recombinant Human TREM2 protein, mFc-tagged HEK293 mFc His 19 - Ser 174
Human TREM2-161H-B Recombinant Human TREM2 Protein Pre-coupled Magnetic Beads HEK293
Human TREM2-1024H Recombinant Human TREM2 protein, His-tagged HEK293 His His 19 - Ser 174
Mouse Trem2-272R Active Recombinant Mouse Trem2 protein, His-tagged Mammalian cells His
Mouse Trem2-3276M Recombinant Mouse Trem2, His-tagged HEK293 His Met 1-Pro 168
Mouse Trem2-311M Active Recombinant Mouse Trem2 protein, His-tagged HEK293 His Leu 19 - Ser 171
Mouse Trem2-848M Recombinant Mouse Trem2 Protein, His-tagged HEK293 His
Mouse Trem2-847M Recombinant Mouse Trem2 Protein, Fc-tagged HEK293 Fc
Mouse TREM2-2186MCL Recombinant Mouse TREM2 cell lysate Human Cell N/A
Mouse Trem2-9578M Recombinant Mouse Trem2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Trem2-9578M-B Recombinant Mouse Trem2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Trem2-535M Recombinant Mouse Trem2 Protein, His/GST-tagged E.coli His/GST Met1~Thr227
Mouse Trem2-312M Active Recombinant Mouse Trem2 protein, Fc-tagged HEK293 Fc Leu 19 - Ser 171
Mouse Trem2-3621M Recombinant Mouse Trem2 protein, His-tagged E.coli His 19-171aa
Mouse Trem2-6616M Recombinant Mouse Trem2 Protein (Lys19-Thr227), C-Fc tagged Mammalian cells C-Fc Lys19-Thr227
Rat Trem2-536R Recombinant Rat Trem2 Protein, His/GST-tagged E.coli His/GST Met1~Leu228
Cynomolgus TREM2-313C Active Recombinant Cynomolgus TREM2 protein, His-tagged HEK293 His His 19 - Ser 174
Chicken TREM2-3301C Recombinant Chicken TREM2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TREM2 Related Articles
  • TREM2 Related Research Area

TREM2 involved in several pathways and played different roles in them. We selected most pathways TREM2 participated on our site, such as Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TREM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Osteoclast differentiationCSF1;TRAF2;NCF1;TGFBR1;MAPK13;SQSTM1;TAB2;GAB2;FCGR4

TREM2 has several biochemical functions, for example, lipopolysaccharide binding, lipoteichoic acid binding, peptidoglycan binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TREM2 itself. We selected most functions TREM2 had, and list some proteins which have the same functions with TREM2. You can find most of the proteins on our site.

Function Related Protein
lipopolysaccharide bindingSCARB1;BPIFA2;HSPD1;CD6;TLR2;PTAFR;LBP;DROSHA;CD14
lipoteichoic acid bindingTREM2;CD6;LBP;CD14;TLR2
peptidoglycan bindingPGLYRP2;TLR2;NLRP3;PGLYRP1;TREM2;PGLYRP4;NOD1;PGLYRP3;RNASE7
receptor activityMED17;MED1;CNTNAP1;ITGB1B;IL10RB;CD40;THRAP3;NLGN3B;NLGN2B
scaffold protein bindingKCNA5;VIM;MDM2;CASP8;IKBKB;CAV2;PARK7;NLGN3;KRT18

TREM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TREM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TREM2.

Satoh, J; Kawana, N; et al. A survey of TREM2 antibodies reveals neuronal but not microglial staining in formalin-fixed paraffin-embedded postmortem Alzheimer's brain tissues. ALZHEIMERS RESEARCH & THERAPY 5:-(2013).
Satoh, J; Tabunoki, H; et al. Immunohistochemical characterization of microglia in Nasu-Hakola disease brains. NEUROPATHOLOGY 31:363-375(2011).
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Customer Reviews (3)

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Reviews
11/25/2020

    Their expertise and prompt assistance have been instrumental in overcoming challenges and optimizing the use of the TREM2 protein in my studies.

    02/25/2019

      The manufacturer's commitment to delivering excellent technical support has proven to be invaluable in troubleshooting any issues that arose during my experiments.

      09/25/2017

        I am extremely satisfied with the high performance and the exceptional support associated with this protein, as it has greatly contributed to the success of my scientific endeavors.

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