trem2
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  • Official Full Name
  • triggering receptor expressed on myeloid cells 2
  • Background
  • The protein encoded by this gene is a membrane protein that forms a receptor signaling complex with TYROBP. The encoded;protein may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines.;Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy;(PLOSL).
  • Synonyms
  • TREM2; triggering receptor expressed on myeloid cells 2; triggering receptor expressed on myeloid cells 2a; TREM 2; Trem2a; Trem2b; Trem2c; triggering receptor expressed on monocytes 2; TREM-2
Cat.#:TREM2-282HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human TREM2 Protein, His-tagged
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Cat.#:Trem2-535MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Trem2 Protein, His/GST-tagged
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Cat.#:Trem2-536RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Trem2 Protein, His/GST-tagged
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Cat.#:Trem2-3276MTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Mouse Trem2, His-tagged
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Cat.#:TREM2-2452HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant human TREM2, His-tagged
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Cat.#:TREM2-3111HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TREM2, His tagged
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Cat.#:TREM2-715HTag:Fc
Source (Host):NSO CellsSpecies:Human
Product nameRecombinant Human TREM2 Protein, Fc Chimera
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Cat.#:Trem2-272RTag:His
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Trem2 protein, His-tagged
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Cat.#:Trem2-847MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Trem2 Protein, Fc-tagged
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Cat.#:Trem2-848MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Trem2 Protein, His-tagged
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Cat.#:TREM2-3301CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TREM2
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Cat.#:TREM2-2649HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human TREM2 cell lysate
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Cat.#:TREM2-2186MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse TREM2 cell lysate
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Involved Pathway

TREM2 involved in several pathways and played different roles in them. We selected most pathways TREM2 participated on our site, such as Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TREM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Osteoclast differentiation
IFNGR1; IFNGR2; STAT1; MAPK13; AKT2; CYBB; TNFRSF11B; CALCR; PPP3CC; BLNK

Protein Function

TREM2 has several biochemical functions, for example, lipopolysaccharide binding, lipoteichoic acid binding, peptidoglycan binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TREM2 itself. We selected most functions TREM2 had, and list some proteins which have the same functions with TREM2. You can find most of the proteins on our site.
Function
Related Protein
Function lipopolysaccharide binding
Related Protein CD6; KIAA0644; TRIL; PSMB4; TREM2; BPIFA2; TLR2; SPON2; TLR4; P2RX7
Function lipoteichoic acid binding
Related Protein LBP; CD14; CD6; TREM2; TLR2
Function peptidoglycan binding
Related Protein NLRP3; TLR2; PGLYRP4; PGLYRP2; NOD1; RNASE7; PGLYRP1; TREM2; PGLYRP3
Function receptor activity
Related Protein NEO1; LILRB3; CXCR3; AGER; MRC1; IL18R1; PAQR3B; LILRB4; RTN4RL2; PVRL4
Function scaffold protein binding
Related Protein NLGN4X; CIT; CAV2; KRT15; SCN5A; MAP2K2; PANX1; VIM; KCNQ1; KCNH2

TREM2 Related Articles

Satoh, J; Kawana, N; et al. A survey of TREM2 antibodies reveals neuronal but not microglial staining in formalin-fixed paraffin-embedded postmortem Alzheimer's brain tissues. ALZHEIMERS RESEARCH & THERAPY 5:-(2013).
Satoh, J; Tabunoki, H; et al. Immunohistochemical characterization of microglia in Nasu-Hakola disease brains. NEUROPATHOLOGY 31:363-375(2011).