TREM2
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Official Full Name
triggering receptor expressed on myeloid cells 2
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Overview
The protein encoded by this gene is a membrane protein that forms a receptor signaling complex with TYROBP. The encoded;protein may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines.;Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy;(PLOSL). -
Synonyms
TREM2; triggering receptor expressed on myeloid cells 2; triggering receptor expressed on myeloid cells 2a; TREM 2; Trem2a; Trem2b; Trem2c; triggering receptor expressed on monocytes 2; TREM-2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Cynomolgus
- Human
- Mouse
- Rat
- E. coli
- E.coli
- HEK293
- HEK294
- Human Cell
- Mammalian Cell
- Mammalian cells
- Mouse myeloma cell line
- Wheat Germ
- Yeast
- C
- Fc
- His
- Avi
- GST
- His (Fc)
- Myc
- His|GST
- mFc
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- TREM2 Related Articles
- TREM2 Related Research Area
TREM2 involved in several pathways and played different roles in them. We selected most pathways TREM2 participated on our site, such as Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TREM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Osteoclast differentiation | IFNGR2;FOSB;TGFB2;NFKB2;TGFBR1;TGFB1;FCGR2C;FCGR1;SFPI1 |
TREM2 has several biochemical functions, for example, lipopolysaccharide binding, lipoteichoic acid binding, peptidoglycan binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TREM2 itself. We selected most functions TREM2 had, and list some proteins which have the same functions with TREM2. You can find most of the proteins on our site.
Function | Related Protein |
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lipopolysaccharide binding | CD6;SELP;TLR2;BPIFA2;RNASE7;PTAFR;KIAA0644;SCARB1;HMGB1 |
lipoteichoic acid binding | TLR2;TREM2;CD14;CD6;LBP |
peptidoglycan binding | PGLYRP1;PGLYRP2;RNASE7;NOD1;PGLYRP3;NLRP3;TLR2;PGLYRP4;TREM2 |
receptor activity | BTLA;PLXNA1;NR2C1;CLEC4M;CD1D;GFRA1A;SMAGP;TREML2;PAQR5 |
scaffold protein binding | NLGN1;CHUK;SHANK3;GRIN2A;GRID2;PDE4D;PARK7;LRP4;CACNA1G |
TREM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TREM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TREM2.
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Ask a questionCustomer Reviews (3)
Write a reviewTheir expertise and prompt assistance have been instrumental in overcoming challenges and optimizing the use of the TREM2 protein in my studies.
The manufacturer's commitment to delivering excellent technical support has proven to be invaluable in troubleshooting any issues that arose during my experiments.
I am extremely satisfied with the high performance and the exceptional support associated with this protein, as it has greatly contributed to the success of my scientific endeavors.
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