Recombinant Human TREM2 protein, His-Avi-tagged

• Cat.No.: TREM2-092H
• Product Overview: Human Trem2 Protein is expressed from mammalian with His and Avi Tag at the C-terminal. It contains His19-Ser174.

Specification

• Species: Human
• Source: HEK293
• Tag: Avi&His
• Protein Length: His19-Ser174
• Description: TREM-2 (Triggering Receptor Expressed on Myeloid cells-2) is a 35 kDa type I transmembrane member of the TREM family and Ig superfamily. Mature human TREM-2 consists of a 156 amino acid (aa) extracellular domain (ECD) with one V-type Ig-like domain, a 21 aa transmembrane (TM) domain, and a 35 aa cytoplasmic tail. TREM-2 forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding (PubMed:10799849). Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia.
• Form: Supplied as 0.22um filtered solution in PBS (pH 7.4).
• Molecular Mass: The protein has a predicted MW of 20.3 kDa. Due to glycosylation, the protein migrates to 30- 38KDa based on Bis-Tris PAGE result.
• Endotoxin: Less than 0.2 EU per ug by the LAL method.
• Purity: > 95% as determined by Bis-Tris PAGE
• Storage: The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.

Gene Information

• Gene Name: TREM2 triggering receptor expressed on myeloid cells 2 [ Homo sapiens (human) ]
• Official Symbol: TREM2
• Synonyms: PLOSL2; TREM2; TREM-2; Trem2a; Trem2b; Trem2c; TREM-2triggering receptor expressed on myeloid cells 2a; Triggering receptor expressed on monocytes 2; triggering receptor expressed on myeloid cells 2
• Gene ID: 54209
• mRNA Refseq: NM_001271821.2
• Protein Refseq: NP_001258750.1
• MIM: 605086
• UniProt ID: Q9NZC2