Active Recombinant Human TREM2 Protein, His-tagged

• Cat.No.: TREM2-282H
• Product Overview: Recombinant human TREM-2 (His19-Ser174) protein with a C-terminal 6-His tag was expressed in mouse myeloma cell line.

Specification

• Species: Human
• Source: Mouse myeloma cell
• Tag: His
• Description: May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells.
• Predicted N Terminal: His19
• Bio-activity: Measured by its ability to bind fluorescein-conjugated E. coli Bioparticles. The ED50 for this effect is 0.15-0.9 μg/mL using a His Tag Antibody coated plate.
• Molecular Mass: Predicted Molecular Mass: 18 kDa
  SDS-PAGE: 25-39 kDa, reducing conditions
• N-terminal Sequence Analysis: His
• Endotoxin: <0.10 EU per 1 μg of the protein by the LAL method.
• Purity: >90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Storage: Avoid repeated freeze-thaw cycles.
  12 months from date of receipt, -20 to -70 centigrade as supplied.
  1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
  3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution in HEPES and NaCl.
• Reconstitution: Reconstitute at 500 μg/mL in water.

Gene Information

• Gene Name: TREM2
• Official Symbol: TREM2 triggering receptor expressed on myeloid cells 2 [ Homo sapiens (human) ]
• Synonyms: TREM2; TREM-2; Trem2a; Trem2b; Trem2c; TREM-2triggering receptor expressed on myeloid cells 2a; Triggering receptor expressed on monocytes 2; triggering receptor expressed on myeloid cells 2; triggering receptor expressed on myeloid cells 2; triggering receptor expressed on monocytes 2; triggering receptor expressed on myeloid cells 2a
• Gene ID: 54209
• mRNA Refseq: NM_018965
• Protein Refseq: NP_061838
• MIM: 605086
• UniProt ID: Q9NZC2