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ZAP70

  • Official Full Name

    ZAP70 zeta-chain (TCR) associated protein kinase 70kDa

  • Synonyms

    ZAP70; zeta-chain (TCR) associated protein kinase 70kDa; SRK, zeta chain (TCR) associated protein kinase (70 kD); tyrosine-protein kinase ZAP-70; STD; ZAP 70; syk-related tyrosine kinase; 70 kDa zeta-associated protein; 70 kDa zeta-chain associated protein; zeta-chain associated protein kinase, 70kD; SRK; FLJ17670; FLJ17679; ZAP70; zeta-chain (TCR) associated protein kinase 70kDa; TZK; Tyrosine-protein kinase ZAP-70; 70 kDa zeta-associated protein Syk-related tyrosine kinase; EC 2.7.10.2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect (sf21)
  • Insect cells
  • Mammalian Cell
  • Mammalian cells
  • Sf21
  • Sf9 Insect Cell
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ZAP70-187HFL Active Recombinant Full Length Human ZAP70 Protein, C-His-tagged Sf21 His Full Length
Human ZAP70-3777H Recombinant Human ZAP70, GST-tagged E.coli GST 235-393aa
Human ZAP70-1511H Active Recombinant Human ZAP70 Protein, GST-tagged Insect cells GST
Human ZAP70-458H Recombinant Human ZAP70, GST-tagged, Active Sf9 Insect Cell GST
Human ZAP70-750H Recombinant Human ZAP70, GST-His Sf9 Insect Cell GST
Human ZAP70-98H Recombinant Human Zeta-chain (TCR) Associated Protein Kinase 70kDa E.coli N/A
Human ZAP70-1948HCL Recombinant Human ZAP70 cell lysate N/A
Human ZAP70-1490H Recombinant Human ZAP70 protein, His & T7-tagged E.coli His/T7 Leu337~Leu600 (Accession # P43403)
Human ZAP70-9486HF Active Recombinant Full Length Human ZAP70 Protein, GST-tagged Insect (sf21) GST 1-619(end)
Human ZAP70-885HFL Recombinant Full Length Human ZAP70 Protein, C-Flag-tagged Mammalian cells Flag
Human ZAP70-2382H Recombinant Human ZAP70 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ZAP70-6582H Recombinant Human ZAP70 Protein (Leu337-Leu600), N-His tagged E.coli N-His Leu337-Leu600
Human ZAP70-2382H-B Recombinant Human ZAP70 Protein Pre-coupled Magnetic Beads HEK293
Mouse ZAP70-18692M Recombinant Mouse ZAP70 Protein Mammalian Cell His
Mouse ZAP70-10274M Recombinant Mouse ZAP70 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Zap70-1491M Recombinant Mouse Zap70 protein, His & T7-tagged E.coli His/T7 Ala270~Pro560 (Accession # P43404)
Mouse Zap70-7046M Recombinant Mouse Zap70 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse ZAP70-10274M-B Recombinant Mouse ZAP70 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish ZAP70-2770Z Recombinant Zebrafish ZAP70 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ZAP70 Related Articles
  • ZAP70 Related Research Area

ZAP70 involved in several pathways and played different roles in them. We selected most pathways ZAP70 participated on our site, such as Ras signaling pathway, NF-kappa B signaling pathway, Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with ZAP70 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ras signaling pathwayRASSF1;IKBKB;Fgf15;RASAL2;FGF2;PLD2;PLA2G6;FGF13;PLCE1
NF-kappa B signaling pathwayBCL2;LAT;XIAP;GADD45B;ZAP70;TRADD;CD40;LY96;RELA
Natural killer cell mediated cytotoxicityIFNG;PIK3R5;SHC4;RAC2;NRAS;Raet1c;KRAS;ULBP1;SHC1
T cell receptor signaling pathwayCBL;MAPK13;KRAS;PDPK1;SHB;VAV3;PIK3R2;AKT1;NCK1
Primary iCD40LG;IL2RG;ORAI1;ZAP70;CD3D;CD8A;IGLL1;CD3E;TAP2
nodeficiencyCD3E;AICDA;TAP2;ZAP70;RFX5;RFXANK;UNG;ORAI1;DCLRE1C

ZAP70 has several biochemical functions, for example, ATP binding, non-membrane spanning protein tyrosine kinase activity, phosphotyrosine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ZAP70 itself. We selected most functions ZAP70 had, and list some proteins which have the same functions with ZAP70. You can find most of the proteins on our site.

Function Related Protein
ATP bindingENPP1;SARS2;ASNA1;IQCA1;PRKAA2;MOV10;RHOBTB3;MAP3K4;SWAP70
non-membrane spanning protein tyrosine kinase activityFRK;FGR;WEE2;ABL2;FES;ZNF143B;STYK1;MATK;MELK
phosphotyrosine bindingMAPK3;FGR;SAMSN1;GRB2;PTPN3;ACP2;CBLC;MAPK1;CBL
protein bindingDDX42;EDDM3B;PCID2;SPAG8;CCDC92;ZNF193;PAM;AHCYL2;CP110
protein tyrosine kinase activityKITB;BMX;PTK6B;MUSK;WEE2;ERBB4A;LCK;SHC1;PTK7
receptor bindingNUDT7;HSPA1B;TNFSF9;LAMA3;NXPH3;NRG2B;PLXNC1;NPPA;TRDN

ZAP70 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZAP70 here. Most of them are supplied by our site. Hope this information will be useful for your research of ZAP70.

CD247

Guo, N; Zhang, K; et al. CD147 and CD98 complex-mediated homotypic aggregation attenuates the CypA-induced chemotactic effect on Jurkat T cells. MOLECULAR IMMUNOLOGY 63:253-263(2015).
Ho, KC; Chiang, YJ; et al. CBAP promotes thymocyte negative selection by facilitating T-cell receptor proximal signaling. CELL DEATH & DISEASE 5:-(2014).
  • Q&As
  • Reviews

Q&As (5)

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Can ZAP70 be used to predict the response to immunotherapy in cancer patients? 01/21/2023

Research is ongoing to determine whether ZAP70 levels can predict the response of cancer patients to immunotherapy, particularly in T-cell-related treatments.

What role does ZAP70 play in cancer immunotherapy? 01/16/2022

ZAP70's involvement in T-cell activation makes it relevant in cancer immunotherapy, where it can be targeted to enhance anti-tumor immune responses.

Can ZAP70 testing help in the evaluation of immunodeficiency disorders? 02/01/2021

Yes, ZAP70 testing can identify mutations or deficiencies that may contribute to immunodeficiency disorders, aiding in diagnosis and treatment planning.

How can ZAP70 be assessed in clinical settings? 01/31/2021

ZAP70 expression can be measured through flow cytometry or molecular techniques, providing quantitative information for diagnosis and prognosis.

Are there ongoing research efforts to understand ZAP70's clinical applications? 06/30/2018

Yes, ongoing research aims to explore new clinical applications of ZAP70, including its potential in personalized medicine and targeted therapies.

Customer Reviews (3)

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Reviews
07/26/2017

    Their team of experts is not only knowledgeable about the ZAP70 protein but is also dedicated to assisting researchers like myself in overcoming any challenges that may arise.

    06/20/2017

      Whether it's modifying protocols, providing custom formulations, or offering personalized recommendations, their flexibility ensures that I have the necessary tools to carry out my experiments seamlessly.

      02/03/2016

        This high-quality protein is crucial for the success of my experiments, ensuring that I obtain reliable and meaningful scientific findings.

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