Recombinant Mouse Zap70 Protein, Myc/DDK-tagged

• Cat.No.: Zap70-7046M
• Product Overview: Purified recombinant protein of Mouse zeta-chain (TCR) associated protein kinase (Zap70), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: This gene encodes a member of the protein tyrosine kinase family. The encoded protein is essential for development of T lymphocytes and thymocytes, and functions in the initial step of T lymphocyte receptor-mediated signal transduction. A mutation in this gene causes chronic autoimmune arthritis, similar to rheumatoid arthritis in humans. Mice lacking this gene are deficient in alpha-beta T lymphocytes in the thymus. In humans, mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T lymphocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 70.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Zap70 zeta-chain (TCR) associated protein kinase [ Mus musculus (house mouse) ]
• Official Symbol: Zap70
• Synonyms: ZAP70; zeta-chain (TCR) associated protein kinase; tyrosine-protein kinase ZAP-70; syk-related tyrosine kinase; 70 kDa zeta-associated protein; 70 kDa zeta-chain associated protein; Srk; TZK; mur; 70kDa; mrtle; ZAP-70; AI327364
• Gene ID: 22637
• mRNA Refseq: NM_009539
• Protein Refseq: NP_033565
• UniProt ID: P43404