ZBTB16
-
Official Full Name
zinc finger and BTB domain containing 16 -
Overview
This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. -
Synonyms
ZBTB16;zinc finger and BTB domain containing 16;zinc finger protein 145 (Kruppel like, expressed in promyelocytic leukemia) , ZNF145;zinc finger and BTB domain-containing protein 16;PLZF;zinc finger protein PLZF;zinc finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia);ZNF145
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- Avi
- Fc
- DDK
- Myc
- Flag
Involved Pathway
ZBTB16 involved in several pathways and played different roles in them. We selected most pathways ZBTB16 participated on our site, such as Pathways in cancer,Transcriptional misregulation in cancer,Acute myeloid leukemia, which may be useful for your reference. Also, other proteins which involved in the same pathway with ZBTB16 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pathways in cancer | FASLG,GNA11,GNG11,EGLN3,FZD7,STAT5B,TGFB3,SLC2A1,FH,SPI1 |
| Transcriptional misregulation in cancer | MET,H3F3C,SFPI1,HIST3H3,PML,PAX5,PBX1,REL,HIST1H3A,PLAT |
| Acute myeloid leukemia | RUNX1,PIK3R3,STAT5B,TCF7L2,PIK3CG,PIM1,FLT3,PIK3CB,HRAS,STAT5A |
Protein Function
ZBTB16 has several biochemical functions, for example, DNA binding,RNA polymerase II distal enhancer sequence-specific DNA binding,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ZBTB16 itself. We selected most functions ZBTB16 had, and list some proteins which have the same functions with ZBTB16. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | MEF2CA,LHX1B,POLR1D,ZNF75A,HIST1H3C,CHST13,HOXB1A,ZNF212,ZBED3,TFDP1B |
| protein C-terminus binding | PABPC1,HPCAL4,PHB2,RAD51,TOP2A,CORO1A,XRCC4,VPS4A,SDCBP,TAF13 |
| metal ion binding | PFAS,NQO2,PTS,SHRPRBCK1R,KLF11A,LIAS,PFKM,UBR1,MSS51,MLL1 |
| protein domain specific binding | KCNN2,ZFP521,NEFL,HAND2,LIN7B,ERCC1,SNCA,YWHAE2,DICER1,YWHAQ |
| protein binding | DKK1,DNMT3A,LAT2,NUMA1,DPM3,CIB2,C11orf57,ZNF496,TEF,CGA |
| RNA polymerase II distal enhancer sequence-specific DNA binding | NONO,T,H3F3B,GZF1,SFPI1,SOX10,NR5A1,JUN,RELA,ARX |
| transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding | BACH1,GZF1,PAX4,ARX,PROP1,BACH2,MSC |
| identical protein binding | AHCY,COMMD1,ERN1,SIAH1,SH3BP4,AMELX,LYZ,ORAI1,CTSC,NDE1 |
| protein homodimerization activity | CALCOCO2,DPP4,CHMP3,MTPAP,CDH13,EVLA,PDGFRA,TBC1D22A,CADM4,AIMP1 |
Interacting Protein
ZBTB16 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZBTB16 here. Most of them are supplied by our site. Hope this information will be useful for your research of ZBTB16.
PML;EEF1A1;IL6;Hoxa1;TRAF2
Resources
Research Area
Related Services
Related Products
References
- Zheng, Y; Thomas, A; et al. Quantitative detection of human spermatogonia for optimization of spermatogonial stem cell culture. HUMAN REPRODUCTION 29:2497-2511(2014).
- Pomerantz, RG; Mirvish, ED; et al. Novel approach to gene expression profiling in Sezary syndrome. BRITISH JOURNAL OF DERMATOLOGY 163:1090-1094(2010).
