ZBTB16

  • Official Full Name

    zinc finger and BTB domain containing 16

  • Overview

    This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized.
  • Synonyms

    ZBTB16; zinc finger and BTB domain containing 16; zinc finger protein 145 (Kruppel like, expressed in promyelocytic leukemia) , ZNF145; zinc finger and BTB domain-containing protein 16; PLZF; zinc finger protein PLZF; zinc finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia); ZNF145;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ZBTB16-741HCL Recombinant Human ZBTB16 lysate HEK293 N/A
Human ZBTB16-3639H Recombinant Human ZBTB16 protein, His-tagged E.coli His 394-667 aa
Human ZBTB16-2383H-B Recombinant Human ZBTB16 Protein Pre-coupled Magnetic Beads HEK293
Human ZBTB16-706HFL Recombinant Full Length Human ZBTB16 Protein, C-Flag-tagged Mammalian cells Flag
Human ZBTB16-5544H Recombinant Human ZBTB16 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ZBTB16-2383H Recombinant Human ZBTB16 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Zbtb16-7049M Recombinant Mouse Zbtb16 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rhesus Macaque ZBTB16-5253R Recombinant Rhesus monkey ZBTB16 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ZBTB16-5066R Recombinant Rhesus Macaque ZBTB16 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque ZBTB16-5066R-B Recombinant Rhesus Macaque ZBTB16 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

ZBTB16 involved in several pathways and played different roles in them. We selected most pathways ZBTB16 participated on our site, such as Pathways in cancer, Transcriptional misregulation in cancer, Acute myeloid leukemia, which may be useful for your reference. Also, other proteins which involved in the same pathway with ZBTB16 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Pathways in cancerSTK36;FGF19;ITGA2B;EGLN3;FGF17;NKX3;FH1;IL-8;FGF1
Transcriptional misregulation in cancerMLF1;NFKBIZ;Itgam&Itgb2;ERG;ETV5;FUS;ARNT2;LDB1;HDAC1
Acute myeloid leukemiaAKT2;PIK3R3;CEBPA;RELA;IKBKB;STAT5B;CCND1;MAP2K1;NFKB1

ZBTB16 has several biochemical functions, for example, DNA binding, RNA polymerase II distal enhancer sequence-specific DNA binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ZBTB16 itself. We selected most functions ZBTB16 had, and list some proteins which have the same functions with ZBTB16. You can find most of the proteins on our site.

Function Related Protein
DNA bindingMCM6L;TOX3;TBX10;ISL2B;NEUROG1;NAT14;H2AFB1;LHX2A;CMYB
RNA polymerase II distal enhancer sequence-specific DNA bindingNFE2L1;PROP1;BACH1A;TFAP2C;NFE2L2;MEOX2;ATF2;ARX;TAL1
identical protein bindingDRD2;DES;PRKD1;APLP1;PPP1R13L;RIPK1;TLE1;DIAPH1;GRB2
metal ion bindingRNF187;RNF180;CYGB2;AEBP2;ZNRF3;ERI1;ZNF426;OSGEP;ZFP768
protein C-terminus bindingYAP1;ECM1;KCNK3;XRCC6;CTGF;MPDZ;SNF8;VPS4A;NPAT
protein bindingAcr;RPUSD4;HSPA8;TAF11;ROR2;PCSK5;WNT2;IL33;EPS15L1
protein domain specific bindingCTBP1;VPS4A;MITD1;WNT3A;WHRN;POU2F2;GUSB;GNAI3;XPA
protein homodimerization activityDPYD;E2F8;FAP;GPD1;BCL2;TESCA;GPD1A;GDNF;CLN6
transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific bindingZBTB16;BACH1;PAX4;GZF1;PROP1;MSC;BACH2;ARX

ZBTB16 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZBTB16 here. Most of them are supplied by our site. Hope this information will be useful for your research of ZBTB16.

PML; EEF1A1; IL6; Hoxa1; TRAF2

Research Area

Related articles

Zheng, Y; Thomas, A; et al. Quantitative detection of human spermatogonia for optimization of spermatogonial stem cell culture. HUMAN REPRODUCTION 29:2497-2511(2014).
Pomerantz, RG; Mirvish, ED; et al. Novel approach to gene expression profiling in Sezary syndrome. BRITISH JOURNAL OF DERMATOLOGY 163:1090-1094(2010).
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