Recombinant Full Length Human ZBTB16 Protein, C-Flag-tagged

• Cat.No.: ZBTB16-706HFL
• Product Overview: Recombinant Full Length Human ZBTB16 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 74.1 kDa
• AA Sequence: MDLTKMGMIQLQNPSHPTGLLCKAN QMRLAGTLCDVVIMVDSQEFHAHRT VLACTSKMFEILFHRNSQHY TLDFLSPKTFQQILEYAYTATLQAK AEDLDDLLYAAEILEIEYLEEQCLK MLETIQASDDNDTEATMADG GAEEEEDRKARYLKNIFISKHSSEE SGYASVAGQSLPGPMVDQSPSVSTS FGLSAMSPTKAAVDSLMTIG QSLLQGTLQPPAGPEEPTLAGGGRH PGVAEVKTEMMQVDEVPSQDSPGAA ESSISGGMGDKVEERGKEGP GTPTRSSVITSARELHYGREESAEQ VPPPAEAGQAPTGRPEHPAPPPEKH LGIYSVLPNHKADAVLSMPS SVTSGLHVQPALAVSMDFSTYGGLL PQGFIQRELFSKLGELAVGMKSESR TIGEQCSVCGVELPDNEAVE QHRKLHSGMKTYGCELCGKRFLDSL RLRMHLLAHSAGAKAFVCDQCGAQF SKEDALETHRQTHTGTDMAV FCLLCGKRFQAQSALQQHMEVHAGV RSYICSECNRTFPSHTALKRHLRSH TGDHPYECEFCGSCFRDEST LKSHKRIHTGEKPYECNGCGKKFSL KHQLETHYRVHTGEKPFECKLCHQR SRDYSAMIKHLRTHNGASPY
  QCTICTEYCPSLSSMQKHMKGHKPE EIPPDWRIEKTYLYLCYVTRTRPLE QKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Acute myeloid leukemia, Pathways in cancer

Gene Information

• Gene Name: ZBTB16 zinc finger and BTB domain containing 16 [ Homo sapiens (human) ]
• Official Symbol: ZBTB16
• Synonyms: PLZF; ZNF145
• Gene ID: 7704
• mRNA Refseq: NM_006006.6
• Protein Refseq: NP_005997.2
• MIM: 176797
• UniProt ID: Q05516