Active Recombinant Human BMP6 Protein
Cat.No. : | BMP6-015H |
Product Overview : | The mature recombinant human BMP-6 protein consists of 132 amino acids (382-513) without tag was expressed in E. coli. |
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Description : | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Differential expression of this gene may be associated with progression of breast and prostate cancer. Mutations in this gene may be associated with iron overload in human patients. |
Source : | E. coli |
Species : | Human |
Bio-activity : | Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 for this effect is 0.02-0.15 μg/mL. |
Molecular Mass : | 15 kDa |
Product-Related Proteins : | 382-513 |
Endotoxin : | < 0.1 EU/μg of the protein as determined by the LAL method |
Purity : | > 95 % as determined by SDS-PAGE |
Storage : | At -80 centigrade. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | PBS |
Protein length : | 382-513 |
Gene Name : | BMP6 bone morphogenetic protein 6 [ Homo sapiens (human) ] |
Official Symbol : | BMP6 |
Synonyms : | BMP6; bone morphogenetic protein 6; VGR; VGR1; bone morphogenetic protein 6; Names; VG-1-R; VG-1-related protein; vegetal related growth factor (TGFB-related) |
Gene ID : | 654 |
mRNA Refseq : | NM_001718 |
Protein Refseq : | NP_001709 |
MIM : | 112266 |
UniProt ID : | P22004 |
Products Types
◆ Recombinant Protein | ||
BMP6-4368H | Recombinant Human BMP6 Protein, His (Fc)-Avi-tagged | +Inquiry |
BMP6-656R | Recombinant Rat BMP6 Protein, His (Fc)-Avi-tagged | +Inquiry |
Bmp6-10523M | Recombinant Mouse Bmp6 Protein, His (Fc)-Avi-tagged | +Inquiry |
BMP6-16H | Recombinant Active Human BMP6 Protein, His-tagged(C-ter) | +Inquiry |
Bmp6-713M | Recombinant Mouse Bmp6 Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
BMP6-8430HCL | Recombinant Human BMP6 293 Cell Lysate | +Inquiry |
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Not For Human Consumption!
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Customer Reviews (3)
Write a reviewThe BMP6 protein has proven to be an invaluable tool in protein electron microscopy (EM) structure analysis.
The BMP6 protein is of exceptional quality, making it an ideal choice to meet my experimental needs.
This protein demonstrates great performance in WB assays, providing accurate and reliable results that are crucial for protein analysis.
Q&As (5)
Ask a questionYes, there are several ongoing clinical trials investigating the therapeutic applications of BMP6, including its use in bone regeneration and the treatment of musculoskeletal disorders.
Yes, BMP6 is often used in combination with other growth factors and scaffolds to enhance its regenerative potential, especially in tissue engineering applications.
No, BMP6's influence extends beyond bone health. It has been implicated in various cellular processes, including iron homeostasis, and its therapeutic potential is being explored in multiple medical fields.
BMP6 has therapeutic potential in treating bone disorders, such as non-union fractures and osteoporosis. Its ability to stimulate bone formation makes it a valuable candidate for regenerative medicine.
BMP6 can be administered both locally and systemically, depending on the therapeutic goals. Local administration is often preferred for targeted effects, such as bone regeneration at a specific site.
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