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Active Recombinant Human BMP6 Protein

Cat.No. : BMP6-015H
Product Overview : The mature recombinant human BMP-6 protein consists of 132 amino acids (382-513) without tag was expressed in E. coli.
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Description : This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Differential expression of this gene may be associated with progression of breast and prostate cancer. Mutations in this gene may be associated with iron overload in human patients.
Source : E. coli
Species : Human
Bio-activity : Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 for this effect is 0.02-0.15 μg/mL.
Molecular Mass : 15 kDa
Product-Related Proteins : 382-513
Endotoxin : < 0.1 EU/μg of the protein as determined by the LAL method
Purity : > 95 % as determined by SDS-PAGE
Storage : At -80 centigrade. Avoid repeated freeze-thaw cycles.
Storage Buffer : PBS
Protein length : 382-513
Gene Name : BMP6 bone morphogenetic protein 6 [ Homo sapiens (human) ]
Official Symbol : BMP6
Synonyms : BMP6; bone morphogenetic protein 6; VGR; VGR1; bone morphogenetic protein 6; Names; VG-1-R; VG-1-related protein; vegetal related growth factor (TGFB-related)
Gene ID : 654
mRNA Refseq : NM_001718
Protein Refseq : NP_001709
MIM : 112266
UniProt ID : P22004

Not For Human Consumption!

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Customer Reviews (3)

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Reviews
08/14/2022

    The BMP6 protein has proven to be an invaluable tool in protein electron microscopy (EM) structure analysis.

    11/02/2020

      The BMP6 protein is of exceptional quality, making it an ideal choice to meet my experimental needs.

      10/15/2019

        This protein demonstrates great performance in WB assays, providing accurate and reliable results that are crucial for protein analysis.

        Q&As (5)

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        Are there any ongoing clinical trials involving BMP6? 01/27/2022

        Yes, there are several ongoing clinical trials investigating the therapeutic applications of BMP6, including its use in bone regeneration and the treatment of musculoskeletal disorders.

        Can BMP6 be used in conjunction with other growth factors? 10/09/2017

        Yes, BMP6 is often used in combination with other growth factors and scaffolds to enhance its regenerative potential, especially in tissue engineering applications.

        Is BMP6 only relevant for bone-related conditions? 11/01/2016

        No, BMP6's influence extends beyond bone health. It has been implicated in various cellular processes, including iron homeostasis, and its therapeutic potential is being explored in multiple medical fields.

        How does BMP6 contribute to the treatment of bone disorders? 08/08/2016

        BMP6 has therapeutic potential in treating bone disorders, such as non-union fractures and osteoporosis. Its ability to stimulate bone formation makes it a valuable candidate for regenerative medicine.

        Can BMP6 be administered systemically or is it site-specific? 01/15/2016

        BMP6 can be administered both locally and systemically, depending on the therapeutic goals. Local administration is often preferred for targeted effects, such as bone regeneration at a specific site.

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