Active Recombinant Human CD86, HIgG1 Fc-tagged
Cat.No. : | CD86-356H |
Product Overview : | The extracellular domain of human CD86 [B7-2] (AAH40261.1) (Leu20-His239) is fused to the N-terminus of the Fc region of human IgG1 was expressed in CHO cell |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms |
Source : | CHO cells |
Species : | Human |
Tag : | HIgG1 Fc-tagged |
Form : | Lyophilized from 0.2μm-filtered solution in PBS. |
Bio-activity : | Measured by its ability to induce IL-2 secretion by Jurkat human acute T cell leukemia cells. |
Molecular Mass : | 51 KDa (monomer) |
AA Sequence : | Leu20-His239 |
Endotoxin : | <0.06 eu/μg as determined by lal test.>0.06> |
Purity : | ≥98%, by SDS-PAGE under reducing conditions. |
Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
Reconstitution : | Reconstitute at 100μg/ml in sterile PBS. |
Warning : | Avoid freeze/thaw cycles. |
Gene Name : | CD86 CD86 molecule [ Homo sapiens ] |
Official Symbol : | CD86 |
Synonyms : | CD86; CD86 molecule; CD28LG2, CD86 antigen (CD28 antigen ligand 2, B7 2 antigen); T-lymphocyte activation antigen CD86; B lymphocyte antigen B7 2; B7 2; B7.2; BU63; FUN-1; CTLA-4 counter-receptor B7.2; B-lymphocyte activation antigen B7-2; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen); B70; B7-2; LAB72; CD28LG2; MGC34413; |
Gene ID : | 942 |
mRNA Refseq : | NM_001206924 |
Protein Refseq : | NP_001193853 |
MIM : | 601020 |
UniProt ID : | P42081 |
Chromosome Location : | 3q21 |
Pathway : | Adaptive Immune System, organism-specific biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; CD28 co-stimulation, organism-specific biosystem; CD28 dependent PI3K/Akt signaling, organism-specific biosystem; |
Function : | coreceptor activity; protein binding; receptor activity; |
Products Types
◆ Recombinant Protein | ||
CD86-0873H | Recombinant Human CD86 Protein, His-Flag-StrepII-Tagged | +Inquiry |
Cd86-40M | Recombinant Mouse CD86 Protein (ECD), His-tagged(C-ter) | +Inquiry |
CD86-593C | Recombinant Cynomolgus monkey CD86 Protein, Fc-tagged | +Inquiry |
CD86-704H | Recombinant Human CD86 Protein, His-tagged | +Inquiry |
CD86-597M | Recombinant Mouse CD86 Protein, Fc-tagged | +Inquiry |
◆ Lysates | ||
CD86-2598MCL | Recombinant Mouse CD86 cell lysate | +Inquiry |
CD86-2619HCL | Recombinant Human CD86 cell lysate | +Inquiry |
CD86-1971RCL | Recombinant Rat CD86 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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