Active Recombinant Human CES1 Protein (His19-Glu563), C-10×His tagged

Cat.No. : CES1-13H
Product Overview : Recombinant Human Carboxylesterase 1/CES1 Protein (His19-Glu563) with a C-terminal 10-His tag was expressed in Mouse myeloma cell line.
  • Specification
  • Gene Information
  • Related Products
  • Download
Description : This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene.
Source : Mouse myeloma cell line
Species : Human
Tag : His
Bio-activity : Measured by its ability to hydrolyze p-nitrophenylacetate. The specific activity is > 6000 pmol/min/μg, as measured under the described conditions.
Molecular Mass : Predicted Molecular Mass: 61 kDa
SDS-PAGE: 61 kDa, reducing conditions
Protein Length : His19-Glu563
N-terminal Sequence Analysis : His19
Endotoxin : < 1.0 EU/μg of the protein by the LAL method.
Purity : > 95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
6 months from date of receipt, -20 to -70 centigrade as supplied.
3 months, -20 to -70 centigrade under sterile conditions after opening.
Storage Buffer : Supplied as a 0.2 μm filtered solution in Sodium Acetate and NaCl.
Shipping : The product is shipped with polar packs.
Gene Name : CES1 carboxylesterase 1 [ Homo sapiens (human) ]
Official Symbol : CES1
Synonyms : CES1; carboxylesterase 1; CEH; REH; TGH; ACAT; CE-1; CES2; HMSE; SES1; HMSE1; PCE-1; hCE-1; liver carboxylesterase 1; acyl coenzyme A:cholesterol acyltransferase; brain carboxylesterase hBr1; carboxylesterase 1 (monocyte/macrophage serine esterase 1); carboxylesterase 2 (liver); cholesteryl ester hydrolase; cocaine carboxylesterase; egasyn; human monocyte/macrophage serine esterase 1; methylumbelliferyl-acetate deacetylase 1; monocyte/macrophage serine esterase; retinyl ester hydrolase; serine esterase 1; triacylglycerol hydrolase; EC 3.1.1.1; EC 3.1.1.13; EC 3.1.1.56
Gene ID : 1066
mRNA Refseq : NM_001025194
Protein Refseq : NP_001020365
MIM : 114835
UniProt ID : P23141

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Reviews
  • Q&As

Customer Reviews (3)

Write a review
Reviews
03/29/2022

    Reliable for lab work.

    09/16/2021

      Great value for quality.

      09/03/2020

        Good quality, great service.

        Q&As (7)

        Ask a question
        What is the primary function of the CES1 enzyme in the human body? 09/01/2022

        CES1 hydrolyzes ester and amide bonds in various compounds, including drugs, xenobiotics, and endogenous molecules.

        In which tissues or organs is CES1 most abundantly expressed? 07/10/2021

        CES1 is most abundantly expressed in the liver, playing a significant role in first-pass metabolism.

        How does CES1 contribute to drug metabolism? 09/14/2020

        It metabolizes numerous ester-containing drugs, affecting their pharmacokinetics and pharmacodynamics.

        What is the significance of CES1 in the metabolism of prodrugs? 05/04/2020

        CES1 is crucial for the activation of certain prodrugs, converting them into their active pharmacological forms.

        How can genetic variations in the CES1 gene affect drug response? 03/08/2020

        Genetic variations in CES1 can lead to inter-individual differences in drug metabolism, impacting efficacy and toxicity.

        Are there known inhibitors or activators of CES1, and how might they influence its activity? 04/06/2019

        Certain compounds can inhibit or activate CES1, altering the metabolism of its substrates.

        What role does CES1 play in lipid metabolism? 02/13/2018

        It participates in the hydrolysis of triglycerides and cholesterol esters, contributing to lipid homeostasis.

        Ask a Question for All CES1 Products

        Required fields are marked with *

        My Review for All CES1 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /
        • Service lnquiry:

        Stay Updated on the Latest Bioscience Trends