Recombinant Human CES1 293 Cell Lysate
Cat.No. : | CES1-7564HCL |
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Description : | Antigen standard for carboxylesterase 1 (monocyte/macrophage serine esterase 1) (CES1), transcript variant 3 is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid and then lysed in RIPA Buffer. Protein concentration was determined using a colorimetric assay. The antigen control carries a C-terminal Myc/DDK tag for detection. |
Source : | HEK 293 cells |
Species : | Human |
Components : | This product includes 3 vials: 1 vial of gene-specific cell lysate, 1 vial of control vector cell lysate, and 1 vial of loading buffer. Each lysate vial contains 0.1 mg lysate in 0.1 ml (1 mg/ml) of RIPA Buffer (50 mM Tris-HCl pH7.5, 250 mM NaCl, 5 mM EDTA, 50 mM NaF, 1% NP40). The loading buffer vial contains 0.5 ml 2X SDS Loading Buffer (125 mM Tris-Cl, pH6.8, 10% glycerol, 4% SDS, 0.002% Bromophenol blue, 5% beta-mercaptoethanol). |
Size : | 0.1 mg |
Storage Instruction : | Store at -80°C. Minimize freeze-thaw cycles. After addition of 2X SDS Loading Buffer, the lysates can be stored at -20°C. Product is guaranteed 6 months from the date of shipment. |
Applications : | ELISA, WB, IP. WB: Mix equal volume of lysates with 2X SDS Loading Buffer. Boil the mixture for 10 min before loading (for membrane protein lysates, incubate the mixture at room temperature for 30 min). Load 5 ug lysate per lane. |
Tag : | Non |
Gene Name : | CES1 carboxylesterase 1 [ Homo sapiens ] |
Official Symbol : | CES1 |
Synonyms : | CES1; carboxylesterase 1; carboxylesterase 1 (monocyte/macrophage serine esterase 1); liver carboxylesterase 1; CEH; CES1A1; CES1A2; CES2; HMSE; HMSE1; human monocyte/macrophage serine esterase 1; SES1; egasyn; serine esterase 1; retinyl ester hydrolase; cocaine carboxylesterase; triacylglycerol hydrolase; carboxylesterase 2 (liver); brain carboxylesterase hBr1; cholesteryl ester hydrolase; monocyte/macrophage serine esterase; methylumbelliferyl-acetate deacetylase 1; acyl coenzyme A:cholesterol acyltransferase; acyl-coenzyme A:cholesterol acyltransferase; REH; TGH; ACAT; PCE-1; MGC117365; |
Gene ID : | 1066 |
mRNA Refseq : | NM_001266 |
Protein Refseq : | NP_001257 |
UniProt ID : | P23141 |
Chromosome Location : | 16q22.2 |
Pathway : | Drug metabolism - other enzymes, organism-specific biosystem; Drug metabolism - other enzymes, conserved biosystem; E2F transcription factor network, organism-specific biosystem; Fluoropyrimidine Activity, organism-specific biosystem; Irinotecan Pathway, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; retinol biosynthesis, conserved biosystem; |
Function : | carboxylesterase activity; hydrolase activity; methyl indole-3-acetate esterase activity; methyl jasmonate esterase activity; methyl salicylate esterase activity; methylumbelliferyl-acetate deacetylase activity; retinyl-palmitate esterase activity; |
Products Types
◆ Recombinant Protein | ||
CES1-748H | Active Recombinant Human CES1 Protein, His-tagged | +Inquiry |
Ces1-5787M | Recombinant Mouse Ces1 protein, His&Myc-tagged | +Inquiry |
CES1-106H | Active Recombinant Human CES1 Protein | +Inquiry |
CES1-151C | Recombinant Cynomolgus Monkey CES1 Protein, His (Fc)-Avi-tagged | +Inquiry |
CES1-1148H | Recombinant Human CES1 Protein, GST-Tagged | +Inquiry |
◆ Lysates | ||
CES1-7565HCL | Recombinant Human CES1 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-0207 | Carboxylesterase 1 Activity Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewReliable for lab work.
Great value for quality.
Good quality, great service.
Q&As (7)
Ask a questionCES1 hydrolyzes ester and amide bonds in various compounds, including drugs, xenobiotics, and endogenous molecules.
CES1 is most abundantly expressed in the liver, playing a significant role in first-pass metabolism.
It metabolizes numerous ester-containing drugs, affecting their pharmacokinetics and pharmacodynamics.
CES1 is crucial for the activation of certain prodrugs, converting them into their active pharmacological forms.
Genetic variations in CES1 can lead to inter-individual differences in drug metabolism, impacting efficacy and toxicity.
Certain compounds can inhibit or activate CES1, altering the metabolism of its substrates.
It participates in the hydrolysis of triglycerides and cholesterol esters, contributing to lipid homeostasis.
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