Home / Products / ces1


Official Full Name carboxylesterase 1
Background This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Synonyms CES1; carboxylesterase 1; CEH; REH; TGH; ACAT; CE-1; CES2; HMSE; SES1; HMSE1; PCE-1; hCE-1; liver carboxylesterase 1; egasyn; serine esterase 1; retinyl ester hydrolase; cocaine carboxylesterase; triacylglycerol hydrolase; carboxylesterase 2 (liver); brain carboxylesterase hBr1; cholesteryl ester hydrolase; monocyte/macrophage serine esterase; methylumbelliferyl-acetate deacetylase 1; acyl coenzyme A:cholesterol acyltransferase; acyl-coenzyme A:cholesterol acyltransferase; human monocyte/macrophage serine esterase 1; carboxylesterase 1 (monocyte/macrophage serine esterase 1);
    • Species :
    • Cynomolgus Monkey
    • Human
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CES1-106H Recombinant Human CES1 Protein E. coli
    Human CES1-11125H Recombinant Human CES1, His-tagged E.coli His
    Human CES1-1148H Recombinant Human CES1 Protein, GST-Tagged Wheat Germ GST
    Human CES1-29351TH Recombinant Human CES1 Wheat Germ N/A
    Human CES1-3200H Recombinant Human CES1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CES1-3468H Recombinant Human CES1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CES1-4193H Recombinant Human CES1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CES1-5361H Recombinant Human CES1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CES1-602H Recombinant Human CES1 Protein, His-tagged E.coli His
    Human CES1-748H Recombinant Human CES1 Protein, His-tagged Insect Cell His
    Human CES1-7564HCL Recombinant Human CES1 293 Cell Lysate HEK293 N/A
    Human CES1-7565HCL Recombinant Human CES1 293 Cell Lysate HEK293 N/A
    Human CES1-900H Recombinant Human CES1, His-tagged Mammalian Cell His
    Human CES1-911H Recombinant Human CES1 Protein, His-tagged HEK293 His
    Cynomolgus Monkey CES1-403C Recombinant Cynomolgus CES1 Protein, His-tagged Mammalian Cell His
    Kit-0207 Carboxylesterase 1 Activity Assay Kit N/A

    ces1 involved in several pathways and played different roles in them. We selected most pathways ces1 participated on our site, such as Biological oxidations, Drug metabolism - other enzymes, E2F transcription factor network, which may be useful for your reference. Also, other proteins which involved in the same pathway with ces1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Biological oxidations CYP3A7; CYP27A1; COMT; CYP2D6; UGT1B5; CYP2V1; GLYATL2; PRKRA; GLYATL1; NCOA2
    Drug metabolism - other enzymes GMPS; TK2; UGT2A1; NAT1; UCKL1; UPP2; TYMP; UGT2A3; UGT2B7; DPYD
    E2F transcription factor network RBBP8; E2F4; CDKN2C; CEBPA; MYBL2; TRIM28; UXT; RYBP; E2F6; CBX5
    Fluoropyrimidine Activity SLC22A7; TYMP; DHFR; UPP2; CES1; DPYS; DPYD
    Irinotecan Pathway CYP3A5; CES1; BCHE; ABCC2
    Metabolism ABHD3; PCBD1; GPHNA; PDK3B; SCP2B; SACM1L; BHMT2; YY2; FABP9; ACOT9
    Phase 1 - Functionalization of compounds CYP2U1; CYP2K16; CYP4F12; CYP2Y3; CYP8B2; CYP3A7-CYP3AP1; CYP2R1; CYP26A1; CYP3A7; CYP2C18

    ces1 has several biochemical functions, for example, carboxylic ester hydrolase activity, methylumbelliferyl-acetate deacetylase activity, sterol esterase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ces1 itself. We selected most functions ces1 had, and list some proteins which have the same functions with ces1. You can find most of the proteins on our site.

    Function Related Protein
    carboxylic ester hydrolase activity ABHD11; NCEH1A; ACOT11; ABHD2B; NCEH1; NCEH1B; LIPCA; Ces2c; ABHD4; ACOT12
    methylumbelliferyl-acetate deacetylase activity CES2; CES1; ESD
    sterol esterase activity CES1; CES3; LIPA; CEL.1; Cel; CES5A; CES1D
    triglyceride lipase activity CES1D; LIPE; LIPF; PNPLA4; CEL.1; AADAC; PNLIPRP3; CES1; LIPCA; PNPLA3

    ces1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ces1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ces1.


    Ishizuka, T; Yoshigae, Y; et al. Different Hydrolases Involved in Bioactivation of Prodrug-Type Angiotensin Receptor Blockers: Carboxymethylenebutenolidase and Carboxylesterase 1. DRUG METABOLISM AND DISPOSITION 41:1888-1895(2013).
    Zhao, B; Bie, JH; et al. Identification of a novel intracellular cholesteryl ester hydrolase (carboxylesterase 3) in human macrophages: compensatory increase in its expression after carboxylesterase 1 silencing. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 303:C427-C435(2012).

    Related Services & Products

    Apply For A Coupon

    $50 OFF Your First Purchase

    Apply For a Coupon

    Enter your email here to subscribe.

    creative biomart inc.

    Easy access to products and services you need from our library via powerful searching tools.

    Follow Us

    Copyright © 2021 Creative BioMart. All Rights Reserved. Terms and Conditions | Privacy Policy