ces1
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  • Official Full Name
  • carboxylesterase 1
  • Background
  • This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
  • Synonyms
  • CES1; carboxylesterase 1; CEH; REH; TGH; ACAT; CE-1; CES2; HMSE; SES1; HMSE1; PCE-1; hCE-1; liver carboxylesterase 1; egasyn; serine esterase 1; retinyl ester hydrolase; cocaine carboxylesterase; triacylglycerol hydrolase; carboxylesterase 2 (liver); brain carboxylesterase hBr1; cholesteryl ester hydrolase; monocyte/macrophage serine esterase; methylumbelliferyl-acetate deacetylase 1; acyl coenzyme A:cholesterol acyltransferase; acyl-coenzyme A:cholesterol acyltransferase; human monocyte/macrophage serine esterase 1; carboxylesterase 1 (monocyte/macrophage serine esterase 1);
Cat.#:CES1-748HTag:His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human CES1 Protein, His-tagged
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Cat.#:CES1-1148HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CES1 Protein, GST-Tagged
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Cat.#:CES1-3200HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CES1 Protein, MYC/DDK-tagged
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Cat.#:CES1-602HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CES1 Protein, His-tagged
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Cat.#:CES1-11125HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CES1, His-tagged
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Cat.#:CES1-29351THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CES1
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Cat.#:CES1-900HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human CES1, His-tagged
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Cat.#:CES1-911HTag:His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human CES1 Protein, His-tagged
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Cat.#:CES1-403CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CES1 Protein, His-tagged
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Cat.#:CES1-7564HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CES1 293 Cell Lysate
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Cat.#:CES1-7565HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CES1 293 Cell Lysate
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Cat.#:Kit-0207Tag:
Source (Host):Species:
Product nameCarboxylesterase 1 Activity Assay Kit
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Involved Pathway

CES1 involved in several pathways and played different roles in them. We selected most pathways CES1 participated on our site, such as Biological oxidations, Drug metabolism - other enzymes, E2F transcription factor network, which may be useful for your reference. Also, other proteins which involved in the same pathway with CES1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Biological oxidations
TPMT.2; CYP2U1; CYP2B6; SULT1ST6; PRKRA; CYP3A4; CYP2C18; CYP8B2; ADH6; CYP4B1
Drug metabolism - other enzymes
CES2; NAT; PNAT3; CYP2A6; ITPA; IMPDH2; GMPS; UGT1A7; GUSB; UPB1
E2F transcription factor network
UXT; CES1; RBBP8; E2F6; RYBP; SMARCA2; YY1; CES5A; PRMT5; CEBPA
Fluoropyrimidine Activity
UPP2; TYMP; DPYS; DHFR; SLC22A7; CES1; DPYD
Irinotecan Pathway
ABCC2; CYP3A5; BCHE; CES1
Metabolic pathways
NAT; RDH8A; HSD17B1; FUT8A; GALNT18A; SGMS1; AHCYL2; CMPK1; FUT1; ME1
Metabolism
ARL2BP; CHKA; ARF3; HSD17B11; CBLC-1; B3GNT2; ELA2L; ETFA; NDUFAF7; CHST9
Phase 1 - Functionalization of compounds
CYP46A1; CYP2K8; CYP2A7; CYP2AD3; CYP3C4; CYP3C1; CYP2V1; CYP2K6; CYP2K19; CYP2F1

Protein Function

CES1 has several biochemical functions, for example, carboxylic ester hydrolase activity, methylumbelliferyl-acetate deacetylase activity, sterol esterase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CES1 itself. We selected most functions CES1 had, and list some proteins which have the same functions with CES1. You can find most of the proteins on our site.
Function
Related Protein
Function carboxylic ester hydrolase activity
Related Protein CES1D; BAAT; ACOT5; Cel; ACOT10; AADACL2; Ces2e; ACOT1; LYPLAL1; ABHD11
Function methylumbelliferyl-acetate deacetylase activity
Related Protein CES2; CES1; ESD
Function sterol esterase activity
Related Protein Cel; CES1D; CES1; CEL.1; LIPA; CES3; CES5A
Function triglyceride lipase activity
Related Protein CES1; PNPLA4; PNPLA2; CES5A; LIPF; PNLIPRP3; AADAC; LIPCA; CES1D; PNLIP

Interacting Protein

CES1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CES1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CES1.
CREB3

CES1 Related Articles

Ishizuka, T; Yoshigae, Y; et al. Different Hydrolases Involved in Bioactivation of Prodrug-Type Angiotensin Receptor Blockers: Carboxymethylenebutenolidase and Carboxylesterase 1. DRUG METABOLISM AND DISPOSITION 41:1888-1895(2013).
Zhao, B; Bie, JH; et al. Identification of a novel intracellular cholesteryl ester hydrolase (carboxylesterase 3) in human macrophages: compensatory increase in its expression after carboxylesterase 1 silencing. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 303:C427-C435(2012).