Active Recombinant Human FGF10 Protein (169 aa)

Cat.No. : FGF10-421F
Product Overview : Recombinant Human FGF-10 produced in E. coli is a single, non-glycosylated polypeptide chain containing 169 amino acids. A fully biologically active molecule, rhFGF-10 has a molecular mass of 19.3 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
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Description : Fibroblast Growth Factor-10 (FGF-10) is a mitogen mainly produced by mesenchymal stem cells in the lung. FGF-10 belongs to the heparin binding FGF family, and is also known as Keratinocyte Growth Factor-2 (KGF-2). It shares homology with KGF and receptor binding to FGFR2-IIIb. However, while KGF induces proliferation and differentiation of various epithelial cells, FGF-10 promotes budding and branching morphogenesis during the multi-organ development via mesenchymal-epithelial cell interactions. FGF-10 is critical for lung and limb development, and is regulated by Shh during early development.
Source : E. coli
Species : Human
Form : Sterile Filtered White lyophilized (freeze-dried) powder.
Bio-activity : ED50 < 20 ng/mL, measured by a cell proliferation assay using 4 MBr-5 cells, corresponding to a specific activity of > 5.0 × 10^4 units/mg.
Molecular Mass : 19.3 kDa, observed by reducing SDS-PAGE.
Protein Length : 169
AA Sequence : LGQDMVSPEATNSSSSSFSSPSSAG RHVRSYNHLQGDVRWRKLFSFTKYF LKIEKNGKVSGTKKENCPYSILEIT SVEIGVVAVKAINSNYYLAMNKKGK LYGSKEFNNDCKLKERIEENGYNTY ASFNWQHNGRQMYVALNGKGAPRRG QKTRRKNTSAHFLPMVVHS
Endotoxin : < 0.2 EU/μg, determined by LAL method.
Purity : > 95% as analyzed by SDS-PAGE.
Storage : Lyophilized recombinant Human FGF-10 remains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, Human FGF-10 should be stable up to 1 week at 4 centigrade or up to 3 months at -20 centigrade.
Storage Buffer : Lyophilized after extensive dialysis against PBS.
Reconstitution : Reconstituted in ddH2O at 100 μg/mL.
Gene Name : FGF10 fibroblast growth factor 10 [ Homo sapiens ]
Official Symbol : FGF10
Synonyms : FGF10; fibroblast growth factor 10; FGF-10; keratinocyte growth factor 2; produced by fibroblasts of urinary bladder lamina propria;
Gene ID : 2255
mRNA Refseq : NM_004465
Protein Refseq : NP_004456
MIM : 602115
UniProt ID : O15520

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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