Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Active Recombinant Human GRK5, GST-tagged

Cat.No. : GRK5-1410H
Product Overview : Recombinant full-length human GRK5 was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
  • Specification
  • Gene Information
  • Related Products
Description : GRK5 is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. GRK5 plays a role in regulating the motility of polymorphonuclear leukocytes (PMNs). Desensitization of G protein-coupled receptors regulates the number of polymorphonuclear leukocytes (PMNs), as well as their motility and ability to stop upon contact with pathogens or target cells, and this desensitization is mediated by GRK5.
Source : Sf9 Cells
Species : Human
Tag : GST
Form : Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Bio-activity : 40 nmol/min/mg
Molecular Mass : ~95 kDa
Protein length : Full length
Purity : >90%
Applications : Kinase Assay, Western Blot
Storage : Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration : 0.1μg/μl
Gene Name : GRK5 G protein-coupled receptor kinase 5 [ Homo sapiens ]
Official Symbol : GRK5
Synonyms : GRK5; G protein-coupled receptor kinase 5; GPRK5; FP2025; g protein-coupled receptor kinase GRK5; FLJ39780;
Gene ID : 2869
mRNA Refseq : NM_005308
Protein Refseq : NP_005299
MIM : 600870
UniProt ID : P34947
Chromosome Location : 10q24-qter
Pathway : Alpha-synuclein signaling, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; G alpha (q) signalling events, organism-specific biosystem;
Function : ATP binding; G-protein coupled receptor kinase activity; nucleotide binding; phospholipid binding; protein binding; protein kinase C binding; protein serine/threonine kinase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (7)

Ask a question
What therapeutic strategies are being explored involving GRK5 modulation? 08/21/2022

Strategies include developing GRK5 inhibitors for potential use in heart disease and Alzheimer’s.

Are there known genetic mutations in GRK5 associated with specific health conditions? 04/16/2022

Certain GRK5 polymorphisms are associated with hypertension and heart failure risk.

How is GRK5 implicated in neurodegenerative diseases? 09/06/2021

GRK5 has been linked to Alzheimer’s disease through its role in tau phosphorylation.

How does GRK5 regulate G protein-coupled receptor (GPCR) activity? 05/04/2020

It phosphorylates activated GPCRs, promoting β-arrestin binding and receptor internalization.

In which tissues or cell types is GRK5 predominantly expressed? 01/23/2020

GRK5 is widely expressed but has notable levels in the heart and brain.

What role does GRK5 play in cardiovascular function? 01/08/2020

It regulates cardiac contractility and blood pressure, influencing heart function.

What is the main function of GRK5 in cellular signaling? 04/06/2019

GRK5 phosphorylates and desensitizes GPCRs, modulating their signaling.

Customer Reviews (3)

Write a review
Reviews
09/06/2021

    Good product, fast delivery.

    05/08/2021

      Highly recommend, very satisfied.

      03/05/2021

        Worked perfectly, great quality.

        Ask a Question for All GRK5 Products

        Required fields are marked with *

        My Review for All GRK5 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends