hdac6
Share
  • Official Full Name
  • histone deacetylase 6
  • Background
  • Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]
  • Synonyms
  • HDAC6; histone deacetylase 6; HD6; JM21; CPBHM;
Cat.#:HDAC6-313HTag:
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human HDAC6 Protein
+Inquiry
Cat.#:HDAC6-4648HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HDAC6 Protein, GST-tagged
+Inquiry
Cat.#:HDAC6-398HTag:Flag
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Histone Deacetylase 6, FLAG-tagged
+Inquiry
Cat.#:HDAC6-399HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human Histone Deacetylase 6, GST-tagged
+Inquiry
Cat.#:HDAC6-400HTag:Flag
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Histone Deacetylase 6, FLAG-tagged
+Inquiry
Cat.#:HDAC6-401HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Histone Deacetylase 6, His-tagged
+Inquiry
Cat.#:HDAC6-402HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Histone Deacetylase 6, GST-tagged
+Inquiry
Cat.#:HDAC6-131HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HDAC6 protein, His-tagged
+Inquiry
Cat.#:HDAC6-132HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HDAC6 protein, His-tagged
+Inquiry
Cat.#:HDAC6-28922THTag:
Source (Host):Species:Human
Product nameRecombinant Human HDAC6
+Inquiry
Cat.#:HDAC6-397HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Histone Deacetylase 6, GST-tagged
+Inquiry
Cat.#:HDAC6-405HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human HDAC6, GST-tagged
+Inquiry
Cat.#:HDAC6-97HTag:GST
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human HDAC6 Protein, GST-tagged
+Inquiry
Cat.#:Hdac6-1370MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Hdac6 protein, His & T7-tagged
+Inquiry
Cat.#:HDAC6-7533MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HDAC6 Protein
+Inquiry
Cat.#:Hdac6-1371RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Hdac6 protein, His & T7-tagged
+Inquiry
Cat.#:HDAC6-2056RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey HDAC6 Protein, His-tagged
+Inquiry
Cat.#:HDAC6-1359HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human HDAC6 (Active), GST-tagged
+Inquiry
Cat.#:HDAC6-5603HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HDAC6 293 Cell Lysate
+Inquiry
Cat.#:Kit-1028Tag:
Source (Host):Species:
Product nameHDAC6 Activity Assay Kit (Fluorometric)
+Inquiry
Cat.#:Kit-1742Tag:
Source (Host):Species:
Product nameHDAC6 Fluorogenic Assay Kit
+Inquiry

Involved Pathway

HDAC6 involved in several pathways and played different roles in them. We selected most pathways HDAC6 participated on our site, such as Alcoholism, Assembly of the primary cilium, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Alcoholism
HIST1H2AF; GNB3; H3F3A; GNB2; GNB5; HIST1H4B; HIST1H2AL; H2AFY; DRD1; HDAC10
Assembly of the primary cilium
KIFAP3A; TUBG1; BBS2; CSNK1E; PROL1; PLK4; HSPB11; DYNLRB1; CCDC123; BBS4
Cell cycle
ORC6; MCM6; ENSAA; CDKN2D; E2F6; CDC6; TRP53; MAD2L2; HDAC2; GADD45G
Cellular response to heat stress
NUP50; HSPA12B; HSPH1; HSPA14; HDAC6; KIAA1967; DNAJC2; NUP35; HSBP1; BAG5
Cellular responses to stress
CBX8A; DNAJC7; ASF1A; PHC3; KDM6B; HSBP1B; ST13; TXN2; PRDX2; CDKN2C
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HEY2; JAG1; CDK8; CCNC; ADAM10; JAG2; HDAC6; HEY1; HEYL; MIB1
Constitutive Signaling by NOTCH1 PEST Domain Mutants
HEY2; ADAM10; HDAC6; MIB1; HEYL; JAG1; HDAC5; CCNC; JAG2; HEY1
Disease
GPC5; CTBP1; ACAN; MMADHC; FDXR; PSIP1; RLBP1; MYO18A; NUP35; TH1L

Protein Function

HDAC6 has several biochemical functions, for example, Hsp90 protein binding, NAD-dependent histone deacetylase activity (H3-K14 specific), actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC6 itself. We selected most functions HDAC6 had, and list some proteins which have the same functions with HDAC6. You can find most of the proteins on our site.
Function
Related Protein
Function Hsp90 protein binding
Related Protein UNC45B; STUB1; TELO2; NASP; PPEF2; CSNK2A1; FKBP6; PACRG; ERN1; GBP1
Function NAD-dependent histone deacetylase activity (H3-K14 specific)
Related Protein HDAC5; HDAC7; HDAC7A; HDAC2; HDAC1; HDAC10; HDAC9B; HDAC4; HDAC6; HDAC8
Function actin binding
Related Protein DST; PDLIM5; MTSS1L; VPS18; ANG; MYO1F; CFL2; VPS16; POF1B; YWHAH
Function alpha-tubulin binding
Related Protein DDL-2; CAV3; TRPV4; SERPINB1A; WASH; SNCA; ARL4C; HDAC6; B4GALT1; SPAST
Function beta-catenin binding
Related Protein LEF1; AXIN2; CXADR; TBL1X; DACT2; KDM6B; CHD8; DACT3; RORA; LZTS2A
Function beta-tubulin binding
Related Protein OST4; SPAST; ARL8B; SERPINB1A; RGS2; ADNP; UXT; PIFO; HDAC6; LRPPRC
Function core promoter binding
Related Protein HDAC2; ELK4; DHX36; AGO1; EP300; KDM3A; IFI203; RBMX; CLOCK; E2F7
Function dynein complex binding
Related Protein TPR; CCDC155; HDAC6
Function enzyme binding
Related Protein CALU; SLC12A3; XRCC1; CYP2A6; JUND; HDAC6; RPS19BP1; POLB; TNKS2; PARK2
Function histone deacetylase activity
Related Protein ATXN3L; HDAC10; HDAC3; MTA2; HDAC2; SIRT2; HDAC5; HDAC1; HDAC11; NACC2
Function histone deacetylase binding
Related Protein HDAC4; SIRT2; NACC2; XBP1; KAT2A; HDAC3; NIPBL; MEF2D; KAT2B; YWHAE
Function microtubule binding
Related Protein KIFC2; JAKMIP2; APC2; DNM2; GAS2L2; NDEL1; CETN1; NME8; JAKMIP1; CRYAB
Function misfolded protein binding
Related Protein TOR1A; DNAJC10; HSPA5; SDF2L1; DNAJC3; STUB1; EDEM1; DNAJB9; HDAC6; BAG6
Function polyubiquitin binding
Related Protein SHARPIN; VCP; UBQLN4; THRSP; BAG6; TNIP3; RAD23A; BRCC3; PSMD4B; HDAC6
Function protein binding
Related Protein RPLP1; TBX3; FOXC2; TAE1; FCER1G; HACL1; ANKRD45; C6orf226; TLX1; TUBA1B
Function tau protein binding
Related Protein SERPINB1A; PPP2R2A; HDAC6; APOE; BIN1; DYRK1A; FKBP4; S100B; SNCA; AATF
Function tubulin deacetylase activity
Related Protein HDAC6; SIRT2
Function ubiquitin protein ligase binding
Related Protein GABARAPL2; TRIB3; MID1; DNM1L; HSPA9; RELA; CD40; HM13; NGFR; ERBB2
Function zinc ion binding
Related Protein ZFP37; TIMM13; BTR18; FTR82; PDZRN3; SIRT3; TRAF7; MYLIPB; BMP1A; TRIM67

Interacting Protein

HDAC6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC6 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC6.
EGFR; UBC; CYLD; ADRBK1

HDAC6 Related Articles

Bobrowicz, M; Dwojak, M; et al. HDAC6 INHIBITION AUGMENTS THE EFFICACY OF ANTI-CD20 MONOCLONAL ANTIBODIES BY UP-REGULATING CD20 LEVEL IN MALIGNANT B-CELLS. HAEMATOLOGICA 99:437-437(2014).
Noack, M; Leyk, J; et al. HDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytes. GLIA 62:535-547(2014).