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Official Full Name histone deacetylase 6
Background Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]
Synonyms HDAC6; histone deacetylase 6; HD6; JM21; CPBHM;
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293 cells
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • C-Myc/DDK
    • Flag
    • GST
    • His
    • T7
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HDAC6-096H Recombinant Human HDAC6 Protein, GST-tagged Insect cell GST
    Human HDAC6-111H Recombinant Human HDAC6 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human HDAC6-131H Recombinant Human HDAC6 protein, His-tagged E.coli His
    Human HDAC6-132H Recombinant Human HDAC6 protein, His-tagged E.coli His
    Human HDAC6-1359H Recombinant Human HDAC6 (Active), GST-tagged Sf9 Insect Cell GST
    Human HDAC6-28922TH Recombinant Human HDAC6 N/A
    Human HDAC6-313H Recombinant Human HDAC6 Protein HEK293 cells N/A
    Human HDAC6-397H Recombinant Human Histone Deacetylase 6, GST-tagged Insect Cell GST
    Human HDAC6-398H Recombinant Human Histone Deacetylase 6, FLAG-tagged E.coli Flag
    Human HDAC6-399H Recombinant Human Histone Deacetylase 6, GST-tagged Wheat Germ GST
    Human HDAC6-400H Recombinant Human Histone Deacetylase 6, FLAG-tagged Insect Cell Flag
    Human HDAC6-401H Recombinant Human Histone Deacetylase 6, His-tagged Insect Cell His
    Human HDAC6-402H Recombinant Human Histone Deacetylase 6, GST-tagged E.coli GST
    Human HDAC6-405H Recombinant Human HDAC6, GST-tagged Sf9 Insect Cell GST
    Human HDAC6-41H Recombinant Human HDAC6 Protein, GST-tagged Insect Cell GST
    Human HDAC6-4648H Recombinant Human HDAC6 Protein, GST-tagged Wheat Germ GST
    Human HDAC6-5603HCL Recombinant Human HDAC6 293 Cell Lysate HEK293 N/A
    Human HDAC6-97H Recombinant Human HDAC6 Protein, GST-tagged Insect Cell GST
    Mouse Hdac6-1104M Recombinant Mouse Hdac6 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse Hdac6-1370M Recombinant Mouse Hdac6 protein, His & T7-tagged E.coli His/T7
    Mouse HDAC6-7533M Recombinant Mouse HDAC6 Protein Mammalian Cell His
    Rat Hdac6-1371R Recombinant Rat Hdac6 protein, His & T7-tagged E.coli His/T7
    Rhesus Macaque HDAC6-2056R Recombinant Rhesus monkey HDAC6 Protein, His-tagged Mammalian Cell His
    Kit-1028 HDAC6 Activity Assay Kit (Fluorometric) N/A
    Kit-1742 HDAC6 Fluorogenic Assay Kit N/A

    hdac6 involved in several pathways and played different roles in them. We selected most pathways hdac6 participated on our site, such as Alcoholism, Assembly of the primary cilium, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with hdac6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Alcoholism HIST1H2BD; NTRK2; GM14479; GNAS; GNG4; HIST3H2BB-PS; MAPK1; TH; HDAC3; HIST1H2BN
    Assembly of the primary cilium UNC119.1; BBS2; TMEM216; BBS7; CETN2; TTC30A1; SDCCAG8; FBF1; TNPO1; PROL1
    Cellular response to heat stress C11orf73; DNAJC2; BAG5; DNAJB6; HSPA7; NUPL2; NUP50; DPF1; HSBP1; NUP35
    Cellular responses to stress EGLN2; MAPKAPK2B; PHC3; EP400; CBX4; TERF2; HSPA14; ACD; POT1; RBBP4
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDAC6; HEYL; CDK8; HEY1; ADAM10; JAG2; CCNC; MIB1; HDAC5; HEY2
    Constitutive Signaling by NOTCH1 PEST Domain Mutants JAG2; HDAC6; JAG1; HEYL; CCNC; MIB1; HEY1; HDAC5; HEY2; CDK8
    Disease CDK9; IPO5; KERA; gag; TIRAP; CHMP4B; MYO18A; NMT1; HDAC6; PACS1

    hdac6 has several biochemical functions, for example, Hsp90 protein binding, NAD-dependent histone deacetylase activity (H3-K14 specific), actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by hdac6 itself. We selected most functions hdac6 had, and list some proteins which have the same functions with hdac6. You can find most of the proteins on our site.

    Function Related Protein
    Hsp90 protein binding EIF2AK3; HDAC6; GBP1; ERBB2; NASP; FKBP6; PPEF2; UNC45B; PPID; CHORDC1
    NAD-dependent histone deacetylase activity (H3-K14 specific) HDAC6; HDAC5; HDAC4; HDAC10; HDAC3; HDAC7; HDAC8; HDAC2; HDAC7A; HDAC11
    actin binding GSN; KIF18A; ACTR3B; NF2; PARVG; MYH1B; LIMCH1A; BAIAP2L1; MYO1H; VPS16
    alpha-tubulin binding PPARGC1A; SERPINB1A; C9orf24; PROL1; DDL-2; BBS4; NDEL1; ARL8A; SNCA; FNTA
    beta-catenin binding C; CBY1; CDH1; TRPC4; PROP1; CARM1; DACT2; CDH5; CALCOCO1; HDAC6
    beta-tubulin binding TRPV4; HDAC6; BBS4; CCT5; CASC1; SIRT2; PIFO; IFT74; PACRG; LRPPRC
    core promoter binding KDM3A; XBP1; HDAC4; NPAS2; IFI16; CALCOCO1; E2F3; INSM1A; HDAC1; E2F8
    dynein complex binding CCDC155; HDAC6; TPR
    enzyme binding APBA3; CALU; ZFHX3; RYR2; PRKCD; PARK7; MLEC; TTN; U2AF2; TH
    histone deacetylase activity HDAC1; HDAC7; HDAC10; MTA2; HDAC9; NACC2; HDAC8; SIRT2; HDAC11; HDAC5
    histone deacetylase binding CBX5; TAL1; NCOR2; BRMS1LA; DHX36; SRF; RBBP4; BRMS1; SKOR2; HEY2
    microtubule binding HAUS8; CAMSAP1; MID1; KIF2A; ARHGEF2; CLIP3; POLB; GCAP14; NME8; PAFAH1B1A
    misfolded protein binding DNAJC3; EDEM1; DNAJC10; TOR1A; F12; DNAJB9; HSPD1; HSPA5; SDF2L1; CLU
    polyubiquitin binding UBQLN4; SHARPIN; BRE; BAG6; PSMD4; TNIP3; FAM175B; PSMD4B; HDAC6; BRCC3
    protein binding CRYBA4; RASL10B; RRAGD; C6orf226; DNAI1; ITGA7; GFPT2; MMS22L; UBA5; RAB3IL1
    tau protein binding DYRK1A; HDAC6; SERPINB1A; BIN1; FKBP4; APOE; S100B; PPP2R2A; SNCA; AATF
    tubulin deacetylase activity HDAC6; SIRT2
    ubiquitin protein ligase binding GABARAPL2; HSPA5; EGFR; UBE2H; ANKRD32; FAF1; DNM1L; TNFRSF14; BAG6; UBE2V1
    zinc ion binding DRP2; RNF17; CNBPA; CPA5; DDX41; MEP1A.2; USP20; ADAMTS7; ESR1; RARB

    hdac6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with hdac6 here. Most of them are supplied by our site. Hope this information will be useful for your research of hdac6.


    Noack, M; Leyk, J; et al. HDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytes. GLIA 62:535-547(2014).

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