Active Recombinant Human IFNAR2, Fc Chimera

Cat.No. : IFNAR2-25H
Product Overview : Recombinant Human Type I interferons (IFN alpha, beta, omega, tau, kappa and zeta) mediate antiviral, antitumor and immunomodulatory functions and these effects are exerted through binding to the type I interferon receptor (IFNR). This receptor is composed of 2 chains, IFNAR1 and IFNAR2. IFNAR2 is a type I membrane protein tyrosine kinase that is widely expressed in different tissues and is a member of the type II cytokine receptor family. It is expressed inHuman 293 cells.
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Cat. No. : IFNAR2-25H
Description : The DJ-1 is a ubiquitously expressed protein involved in various cellular processes including spermatogenesis and fertilization, cancer, RNA-binding, androgen- receptor signaling and oxidative stress.
Source : Human 293 cells.
Amino Acid Sequence : ISYDSPDYTDESCTFKISLRNFRSI LSWELKNHSIVPTHYTLLYTIMSKP EDLKVVKNCANTTRSFCDLTDEWRS THEAYVTVLEGFSGNTTLFSCSHNF WLAIDMSFEPPEFEIVGFTNHINVM VKFPSIVEEELQFDLSLVIEEQSEG IVKKHKPEIKGNMSGNFTYIIDKLI PNTNYCVSVYLEHSDEQAVIKSPLK CTLLPPGQESESAESAKGSSNTKVD KKVEPKSCDKTHTCPPCPAPELLGG PSVFLFPPKPKDTLMISRTPEVTCV VVDVSHEDPEVKFNWYVDGVEVHNA KTKPREEQYNSTYRVVSVLTVLHQD WLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSRDELTKNQ VSLTCLVKGFYPSDIAVEWESNGQP ENNYKTTPPVLDSDGSFFLYSKLTV DKSRWQQGNVFSCSVMHEALHNHYT QKSLSLSPGK.
Molecular Mass : Under reducing conditions Symansis IFNAR2 – FcB Chimera migrates as a broad band between 60 and 85 kDa in SDS-PAGE due to post-translational modifications, in particular glycosylation. This compares with unmodified IFNAR2 - Fc Chimera that has a predicted monomeric molecular mass of 52 kDa.
pI : IFNAR2 – Fc Chimera separates into a number of isoforms with a pI between 5.0 and 6.0 in 2D PAGE due to post-translational modifications, in particular glycosylation.
%Carbohydrate : Purified IFNAR2 - Fc Chimera consists of 15-40% carbohydrate by weight.
Glycosylation : IFNAR2 - Fc Chimera contains N- and O-linked oligosaccharides.
Purity : >95%, as determined by SDS-PAGE and visualized by silver stain.
Formulation : When reconstituted in 0.5 ml sterile phosphate-buffered saline, the solution will contain 1% human serum albumin (HSA) and 10% trehalose.
Reconstitution : It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.
Storage : Lyophilized products should be stored at 2 to 8°C. Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not recommended.
Activity : IFNAR2 - FcB Chimera bound to protein A sepharose beads was able to pull down its ligand, IFNa2b.
Gene Name : IFNAR2 interferon (alpha, beta and omega) receptor 2 [ Homo sapiens ]
Synonyms : IFNAR2; interferon (alpha, beta and omega) receptor 2; IFN-R; IFNABR; IFNARB; IFN-alpha-REC; OTTHUMP00000067674; OTTHUMP00000067676; Interferon alpha/ beta receptor 2; human interferon alpha,beta receptor; human interferon alpha/beta receptor; interferon-alpha/beta receptor beta chain
Gene ID : 3455
mRNA Refseq : NM_000874
Protein Refseq : NP_000865
UniProt ID : P48551
Chromosome Location : 21q22.1
MIM : 602376
Pathway : Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; Natural killer cell mediated cytotoxicity; Toll-like receptor signaling pathway
Function : protein binding; receptor activity; type I interferon receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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