Active Recombinant Human IL17A/IL17F Protein, Biotinylated
Cat.No. : | IL17A&IL17F-165H |
Product Overview : | Recombinant Human IL17A(Gly24-Ala155)/IL17F(Arg21-GLN163) was expressed in CHO, Biotinylated. |
- Specification
- Gene Information
- Related Products
Description : | Human IL-17A/F is an approximately 40 kDa, secreted, disulfide-linked heterodimeric glycoprotein comprised of two members of the IL-17 family of cytokines, IL-17A and IL-17F. Members of this family demonstrate a structural motif termed a cysteine knot that also characterizes a large superfamily of growth factors. Although most cysteine knot superfamily members use three intrachain disulfide bonds to create a knot, IL-17 family molecules generate the same structural form with only two disulfide links. Mature human IL-17A and IL-17F share 61% and 56% amino acid sequence identity with mouse IL-17A and IL-17F, respectively. They share 50% aa sequence identity with each other. IL-17A/F and the IL-17A and IL-17F homodimers are produced by IL-23 activated Th17 cells. The widely expressed receptors IL-17 RA and IL-17 RC form a heterodimer for the binding of IL-17A and IL-17F, as well as the heterodimeric IL-17A/F. IL-17A/F is a biologically active protein that induces chemokine production and airway neutrophilia with intermediate potency between IL-17A (most potent) and IL-17F (least potent). It is up-regulated in immune cells during inflammatory arthritis and contributes to disease severity. |
Source : | CHO |
Species : | Human |
Predicted N Terminal : | Gly24(IL-17A) & Arg21(IL-17F) |
Form : | Lyophilized from a 0.2 μm filtered solution in HCl with BSA as a carrier protein. |
Bio-activity : | Measured by its ability to induce IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 0.4‑2 ng/mL. |
Molecular Mass : | 15 kDa (unlabeled IL-17A), 15 kDa (unlabeled IL-17F) |
Protein length : | IL17A(Gly24-Ala155)/IL17F(Arg21-GLN163) |
Endotoxin : | <1.0 EU per 1 μg of the protein by the LAL method. |
Purity : | >90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining. |
Notes : | Structure / Form: Disulfide-linked heterodimer, Biotinylated via sugars |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile |
Reconstitution : | Reconstitute at 100 μg/mL in 4 mM HCl containing at least 0.1% human or bovine serum albumin |
Gene Name : | IL17A interleukin 17A [ Homo sapiens ] |
Official Symbol : | IL17A |
Synonyms : | IL17A; interleukin 17A; CTLA8, IL17, interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8); interleukin-17A; cytotoxic T lymphocyte associated protein 8; IL 17; IL 17A; CTLA-8; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; cytotoxic T-lymphocyte-associated serine esterase 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); IL17; CTLA8; IL-17; IL-17A; |
Gene ID : | 3605 |
mRNA Refseq : | NM_002190 |
Protein Refseq : | NP_002181 |
MIM : | 603149 |
UniProt ID : | Q16552 |
Products Types
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IL17A-508M | Recombinant Mouse IL17A Protein | +Inquiry |
IL17A-141R | Recombinant Rat IL17A Protein | +Inquiry |
Il17a-093M | Active Recombinant Mouse Il17a Protein | +Inquiry |
◆ Lysates | ||
IL17A-001HCL | Recombinant Human IL17A cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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