Active Recombinant Mouse Il17a Protein (133 aa)
Cat.No. : | Il17a-253I |
Product Overview : | Recombinant murine IL-17A is a 15-20kDa glycosylated cytokine of 133 amino acid polypeptide chain that plays an important role in antimicrobial and chronic inflammation. IL-17 exhibits multiple biological activities on a variety of cells including the induction of IL-6 and IL-8 production in fibroblasts, the enhancement of surface expression of ICAM-1 in fibroblasts, activation of NF-κB and costimulation of T cell proliferation. |
- Specification
- Gene Information
- Related Products
Description : | Interleukin-17A, (also known as CTLA-8) is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpesvirus Saimiri. cDNA clones encoding IL-17 have been isolated from activated rat, mouse and human T cells. IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. |
Source : | CHO |
Species : | Mouse |
Form : | Sterile Filtered White lyophilized (freeze-dried) powder. |
Bio-activity : | Measured by its ability to induce IL-1a, IL-4 and IL-6 production by primary mouse splenocytes. |
Molecular Mass : | 15-22 kDa, observed by reducing SDS-PAGE. |
Protein Length : | 133 |
AA Sequence : | AAIIPQSSACPNTEAKDFLQNVKVN LKVFNSLGAKVSSRRPSDYLNRSTS PWTLHRNEDPDRYPSVIWEAQCRHQ RCVNAEGKLDHHMNSVLIQQEILVL KREPESCPFTFRVEKMLVGVGCTCV ASIVRQAA |
Endotoxin : | < 0.2 EU/μg, determined by LAL method. |
Purity : | > 95% as analyzed by SDS-PAGE. |
Storage : | Lyophilized recombinant Murine Interleukin-17A (IL-17A) remains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, recombinant murine IL-17A should be stable up to 1 week at 4 centigrade or up to 2 months at -20 centigrade. |
Storage Buffer : | Lyophilized after extensive dialysis against PBS. |
Reconstitution : | Reconstituted in ddH2O or PBS at 100 μg/mL. |
Gene Name : | Il17a interleukin 17A [ Mus musculus ] |
Official Symbol : | Il17a |
Synonyms : | IL17A; interleukin 17A; interleukin-17A; cytotoxic T-lymphocyte-associated antigen 8; Il17; Ctla8; IL-17; Ctla-8; IL-17A; |
Gene ID : | 16171 |
mRNA Refseq : | NM_010552 |
Protein Refseq : | NP_034682 |
UniProt ID : | Q62386 |
Products Types
◆ Recombinant Protein | ||
IL17A-141R | Recombinant Rat IL17A Protein | +Inquiry |
Il17a-096M | Recombinant Mouse Il17a Protein, MYC/DDK-tagged | +Inquiry |
Il17a-095M | Active Recombinant Mouse Il17a Protein | +Inquiry |
IL17A-1008P | Recombinant Pig IL17A Protein, His-tagged | +Inquiry |
IL17A-15P | Recombinant Pig IL17A Protein (Gly26-Ser155), C-His tagged, Animal-free, Carrier-free | +Inquiry |
◆ Lysates | ||
IL17A-001HCL | Recombinant Human IL17A cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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