Active Recombinant Mouse Il17a Protein (133 aa)
Cat.No. : | Il17a-253I |
Product Overview : | Recombinant murine IL-17A is a 15-20kDa glycosylated cytokine of 133 amino acid polypeptide chain that plays an important role in antimicrobial and chronic inflammation. IL-17 exhibits multiple biological activities on a variety of cells including the induction of IL-6 and IL-8 production in fibroblasts, the enhancement of surface expression of ICAM-1 in fibroblasts, activation of NF-κB and costimulation of T cell proliferation. |
- Specification
- Gene Information
- Related Products
- Download
Description : | Interleukin-17A, (also known as CTLA-8) is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpesvirus Saimiri. cDNA clones encoding IL-17 have been isolated from activated rat, mouse and human T cells. IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. |
Source : | CHO |
Species : | Mouse |
Form : | Sterile Filtered White lyophilized (freeze-dried) powder. |
Bio-activity : | Measured by its ability to induce IL-1a, IL-4 and IL-6 production by primary mouse splenocytes. |
Molecular Mass : | 15-22 kDa, observed by reducing SDS-PAGE. |
Protein length : | 133 |
AA Sequence : | AAIIPQSSACPNTEAKDFLQNVKVN LKVFNSLGAKVSSRRPSDYLNRSTS PWTLHRNEDPDRYPSVIWEAQCRHQ RCVNAEGKLDHHMNSVLIQQEILVL KREPESCPFTFRVEKMLVGVGCTCV ASIVRQAA |
Endotoxin : | < 0.2 EU/μg, determined by LAL method. |
Purity : | > 95% as analyzed by SDS-PAGE. |
Storage : | Lyophilized recombinant Murine Interleukin-17A (IL-17A) remains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, recombinant murine IL-17A should be stable up to 1 week at 4 centigrade or up to 2 months at -20 centigrade. |
Storage Buffer : | Lyophilized after extensive dialysis against PBS. |
Reconstitution : | Reconstituted in ddH2O or PBS at 100 μg/mL. |
Gene Name : | Il17a interleukin 17A [ Mus musculus ] |
Official Symbol : | Il17a |
Synonyms : | IL17A; interleukin 17A; interleukin-17A; cytotoxic T-lymphocyte-associated antigen 8; Il17; Ctla8; IL-17; Ctla-8; IL-17A; |
Gene ID : | 16171 |
mRNA Refseq : | NM_010552 |
Protein Refseq : | NP_034682 |
UniProt ID : | Q62386 |
Products Types
◆ Recombinant Protein | ||
IL17A-056C | Recombinant Cynomolgus IL17A protein, His-Avi-tagged | +Inquiry |
Il17a-678M | Recombinant Mouse Il17a protein, His-Avi-tagged | +Inquiry |
IL17A-142R | Recombinant Rat IL-17AF Heterodimer Protein | +Inquiry |
Il17a-149M | Recombinant Active Mouse IL17A Protein, His-tagged(C-ter) | +Inquiry |
IL17A-261R | Recombinant Rhesus IL17A protein(Met1-Ala155) | +Inquiry |
◆ Lysates | ||
IL17A-001HCL | Recombinant Human IL17A cell lysate | +Inquiry |
Related Gene
Not For Human Consumption!
Inquiry
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewGood for receptor studies.
Effective in Th17 differentiation.
High bioactivity in various tissue types.
Q&As (10)
Ask a questionAnimal models, such as experimental autoimmune encephalomyelitis, explore IL17A's role in autoimmunity.
Inducing IL17A expression in T cells involves culturing them with specific cytokines.
Studying IL17A's influence on tissue-specific inflammation in humans involves analyzing patient samples.
Neutralizing antibodies block IL17A's effects in cell cultures or animal models.
Multiplex cytokine assays use fluorescent beads to measure IL17A and other cytokines simultaneously.
IL17RA signaling is triggered by IL17A binding and is studied through downstream phosphorylation assays.
Methods like transepithelial electrical resistance (TEER) assay evaluate IL17A's effect on barrier function.
Inflammatory models, like airway inflammation assays, examine IL17A's impact on neutrophil recruitment.
Flow cytometry or intracellular staining help identify IL17A-producing cell subsets within tissues.
Experimental designs combine cancer cell lines with IL17A stimulation to investigate its pro-tumor effects.
Ask a Question for All Il17a Products
Required fields are marked with *
My Review for All Il17a Products
Required fields are marked with *
Inquiry Basket