Recombinant Mouse Il17a, His-tagged

• Cat.No.: Il17a-334M
• Product Overview: Mouse IL-17A (aa 22-158) is fused at the N-terminus to a His-tag.

Specification

• Species: Mouse
• Source: E.coli
• Tag: His
• Protein Length: 22-158 a.a.
• Description: Interleukin-17 (also known as CTLA-8) is a T cell expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpesvirus Saimiri. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. An IL-17 specific mouse cell surface receptor (IL-17R) has been cloned. While the expression of IL-17 mRNA is restricted to activated alphabetaTCR+CD4-CD8-T cells, the expression of mIL-17R mRNA has been detected in virtually all cells and tissues tested. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts; the enhancement of surface expression of ICAM-1 in fibroblasts; activation of NF-kappaB and costimulation of T cell proliferation.
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Purity: ≥95% (SDS-PAGE)
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Storage: Short Term Storage: +4°C; Long Term Storage: -20°C. Avoid freeze/thaw cycles.

Gene Information

• Gene Name: Il17a interleukin 17A [ Mus musculus ]
• Official Symbol: Il17a
• Synonyms: IL17A; interleukin 17A; interleukin-17A; cytotoxic T-lymphocyte-associated antigen 8; Il17; Ctla8; IL-17; Ctla-8; IL-17A
• Gene ID: 16171
• mRNA Refseq: NM_010552
• Protein Refseq: NP_034682
• Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Rheumatoid arthritis, organism-specific biosystem; Rheumatoid arthritis, conserved biosystem
• Function: cytokine activity