Active Recombinant Human IL1RN Protein (153 aa)
| Cat.No. : | IL1RN-103I |
| Product Overview : | Recombinant Human IL1RN Protein without tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
| Description : | Interleukin-1 receptor antagonist (IL-1ra) is a member of the IL-1 family. Endogenous IL-1ra is produced in numerous animal disease models as well as in human autoimmune and chronic inflammatory diseases. It binds to IL-1 receptors in competition with IL-1, but does not elicit intracellular response from this binding. Its role in counteracting the proinflammatory effects of IL-1 is being studied by numerous research groups. IL-4 and IL-13 have been shown to amplify the stimulatory effect of IL1-beta on the production of soluble and intracellular forms of IL1-ra.The regulated expression of IL1ra in various cell types has been shown to be influenced by cytokines. In synovial fibroblasts the synthesis of IL-1ra is markedly enhanced by IL-1, TNF-alpha, or PDGF. |
| Source : | E. coli |
| Species : | Human |
| Form : | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Bio-activity : | Fully biologically active when compared to standard. The ED50 as determined by the dose-dependant inhibition of IL-1 stimulation of D10S cells was found to be 0.5 ng/mL, corresponding to a Specific Activity of ＞2.0 × 10^6 IU/mg. |
| Molecular Mass : | Approximately 17.0 kDa, a single non-glycosylated polypeptide chain containing 153 amino acids. |
| Protein Length : | 153 |
| AA Sequence : | MRPSGRKSSKMQAFRIWDVNQKTFY LRNNQLVAGYLQGPNVNLEEKIDVV PIEPHALFLGIHGGKMCLSCVKSGD ETRLQLEAVNITDLSENRKQDKRFA FIRSDSGPTTSFESAACPGWFLCTA MEADQPVSLTNMPDEGVMVTKFYFQ EDE |
| Endotoxin : | Less than 1 EU/μg of rHuIL-1ra as determined by LAL method. |
| Purity : | >95% by SDS-PAGE and HPLC analyses. |
| Storage : | This lyophilized preparation is stable at 2-8 centigrade, but should be kept at -20 centigrade for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 centigrade. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 to -70 centigrade. Avoid repeated freeze/thaw cycles. |
| Storage Buffer : | Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4. |
| Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20C. Further dilutions should be made in appropriate buffered solutions. |
| Gene Name : | IL1RN interleukin 1 receptor antagonist [ Homo sapiens ] |
| Official Symbol : | IL1RN |
| Synonyms : | IL1RN; interleukin 1 receptor antagonist; interleukin-1 receptor antagonist protein; ICIL 1RA; IL 1RN; IL1F3; IL1RA; interleukin 1 receptor antagonist protein; intracellular interleukin 1 receptor antagonist; IRAP; MGC10430; IL1 inhibitor; IL1RN (IL1F3); type II interleukin-1 receptor antagonist; intracellular IL-1 receptor antagonist type II; intracellular interleukin-1 receptor antagonist (icIL-1ra); DIRA; MVCD4; IL-1RN; IL-1ra; IL-1ra3; ICIL-1RA; |
| Gene ID : | 3557 |
| mRNA Refseq : | NM_000577 |
| Protein Refseq : | NP_000568 |
| MIM : | 147679 |
| UniProt ID : | P18510 |
Products Types
| ◆ Recombinant Protein | ||
| IL1RN-183I | Active Recombinant Human IL1RN Protein | +Inquiry |
| Il1rn-56M | Active Recombinant Mouse Il1rn Protein (Arg27-Gln178), C-His tagged, Animal-free, Carrier-free | +Inquiry |
| IL1RN-2692R | Recombinant Rat IL1RN Protein, His (Fc)-Avi-tagged | +Inquiry |
| IL1RN-167H | Recombinant Active Human IL1RN Protein, His-tagged(C-ter) | +Inquiry |
| IL1RN-1819H | Recombinant Human IL1RN Protein, MYC/DDK-tagged | +Inquiry |
| ◆ Lysates | ||
| IL1RN-2912HCL | Recombinant Human IL1RN cell lysate | +Inquiry |
| IL1RN-1375RCL | Recombinant Rat IL1RN cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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