Il1rn
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Official Full Name
interleukin 1 receptor antagonist
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Background
The interleukin-1 receptor antagonist (IL-1RA) is a protein that in humans is encoded by the IL1RN gene. IL-1RA was initially called the IL-1 inhibitor and was discovered separately in 1984 by two independent laboratories. IL-1RA, is an agent that binds non-productively to the cell surface interleukin-1 receptor (IL-1R). IL-1R is the same receptor that binds interleukin 1 (IL-1). Hence IL-1RA prevents IL-1 from sending a signal to that cell. -
Synonyms
IL1RN; interleukin 1 receptor antagonist; interleukin-1 receptor antagonist protein; ICIL 1RA; IL 1RN; IL1F3; IL1RA; interleukin 1 receptor antagonist protein; intracellular interleukin 1 receptor antagonist; IRAP; MGC10430; IL1 inhibitor; IL1RN (IL1F3); type II interleukin-1 receptor antagonist; intracellular IL-1 receptor antagonist type II; intracellular interleukin-1 receptor antagonist (icIL-1ra); DIRA; MVCD4; IL-1RN; IL-1ra; IL-1ra3; ICIL-1RA;
- Involved Pathway
- Protein Function
- Interacting Protein
- Il1rn Related Articles
- Il1rn Related Gene Family
Il1rn involved in several pathways and played different roles in them. We selected most pathways Il1rn participated on our site, such as Cytokine Signaling in Immune system, IL-1 Signaling Pathway, IL1-mediated signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il1rn were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine Signaling in Immune system | FGF20A;EIF4G2;CNKSR1;GBP5;SPRED1;DAB2IPB;PAQR3B;SPTA1;CRK |
| IL-1 Signaling Pathway | IL1RN;SIRPA;IKBKAP |
| IL1-mediated signaling events | TMEM189-UBE2V1;TMED7-TICAM2;IL1RN;IRAK3 |
| Immune System | ADAR;GZMM;NOD1;BLMH;ICAM4;SPSB2;EIF4E3;CMTM2A;ABI2 |
| Interleukin-1 signaling | IRAK3;PELI2;NOD1;TNIP2;IL1RN;PELI1;PELI3 |
| Leptin signaling pathway | CFL2;IL1RN;KHDRBS1 |
| SIDS Susceptibility Pathways | POU3F2;LMX1B;PHOX2A;MAZ;SP3;DLX2;TPH2;DEAF1;ECE1 |
| Signaling by Interleukins | LGALS9;CASPB;IL1RN;HAVCR2;CASPBL;SOCS3A |
Il1rn has several biochemical functions, for example, cytokine activity, interleukin-1 Type I receptor antagonist activity, interleukin-1 Type II receptor antagonist activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Il1rn itself. We selected most functions Il1rn had, and list some proteins which have the same functions with Il1rn. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | Il1f9;BMP2B;IFNA17;GDF15;FGF2;IL3;MSTNB;IL18;CTF1 |
| interleukin-1 Type I receptor antagonist activity | |
| interleukin-1 Type II receptor antagonist activity | |
| interleukin-1 receptor antagonist activity | Il1f5;IL36RN;IL1RN |
| interleukin-1 receptor binding | IL1B;TLR5;Il1f6;IL37;IL36A;IL1F10;IL1RAP;IL36B;IRAK4 |
| interleukin-1, Type I receptor binding | TOLLIP;IL1RN |
| interleukin-1, Type II receptor binding | IL1RN;ERAP1 |
| protein binding | MYH8;IRF8;FANCL;MYL2;GTF2A2;HRASLS5;CREB3;ADCK5;KCNMA1 |
Il1rn has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il1rn here. Most of them are supplied by our site. Hope this information will be useful for your research of Il1rn.
TERF2IP; IL1R1; POT1
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