Il1rn Protein

Il1rn

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Il1rn

Official Full Name interleukin 1 receptor antagonist
Background The interleukin-1 receptor antagonist (IL-1RA) is a protein that in humans is encoded by the IL1RN gene. IL-1RA was initially called the IL-1 inhibitor and was discovered separately in 1984 by two independent laboratories. IL-1RA, is an agent that binds non-productively to the cell surface interleukin-1 receptor (IL-1R). IL-1R is the same receptor that binds interleukin 1 (IL-1). Hence IL-1RA prevents IL-1 from sending a signal to that cell.
Synonyms IL1RN; interleukin 1 receptor antagonist; interleukin-1 receptor antagonist protein; ICIL 1RA; IL 1RN; IL1F3; IL1RA; interleukin 1 receptor antagonist protein; intracellular interleukin 1 receptor antagonist; IRAP; MGC10430; IL1 inhibitor; IL1RN (IL1F3); type II interleukin-1 receptor antagonist; intracellular IL-1 receptor antagonist type II; intracellular interleukin-1 receptor antagonist (icIL-1ra); DIRA; MVCD4; IL-1RN; IL-1ra; IL-1ra3; ICIL-1RA
    • Species :
    • Cattle
    • Chicken
    • Cynomolgus
    • Cynomolgus Monkey
    • Dog
    • Equine
    • Horse
    • Human
    • Mouse
    • Pig
    • Rabbit
    • Rat
    • Rhesus monkey (Simian)
    • Source :
    • E.coli
    • HEK293
    • HEK293F
    • HEK293T
    • Human Cell
    • Mammalian Cell
    • Mammalian cells
    • Mouse
    • Yeast
    • Tag :
    • Fc
    • Flag
    • His
    • His(C-ter)
    • Met
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IL1RN-115H Active Recombinant Human Interleukin 1 Receptor Antagonist HEK293 N/A Inquiry
    Human IL1RN-188H Active Recombinant Human IL1RN Protein E.coli N/A Inquiry
    Equine IL1RN-945E Active Recombinant Equine IL1RN E.coli Met Inquiry
    Mouse Il1rn-01M Active Recombinant Mouse Il1rn Protein, His-Tagged E.coli His Inquiry
    Human IL1RN-05H Recombinant Human IL1RN protein E.coli N/A Inquiry
    Human IL1RN-28733TH Recombinant Human IL1RN, His-tagged E.coli His Inquiry
    Human IL1RN-314H Recombinant Human IL1RN, Fc tagged Human Cell Fc Inquiry
    Human IL1RN-495H Recombinant Human IL1RN protein, His-tagged HEK293F His Inquiry
    Human IL1RN-51H Recombinant Human Interleukin 1 Receptor Antagonist, His-tagged E.coli His Inquiry
    Mouse Il1rn-15856M Recombinant Mouse Il1rn, His-tagged E.coli His Inquiry
    Mouse Il1rn-231M Recombinant Mouse Interleukin-1 Receptor Antagonist E.coli N/A Inquiry
    Mouse Il1rn-546M Recombinant Mouse Il1rn protein E.coli N/A Inquiry
    Mouse Il1rn-5593M Recombinant Mouse Interleukin 1 Receptor Antagonist, His-tagged E.coli His Inquiry
    Rat Il1rn-107R Recombinant Rat Il1rn, His-tagged E.coli His Inquiry
    Rat IL1RN-3037R Recombinant Rat IL1RN Protein Mammalian Cell His Inquiry
    Rat Il1rn-574R Recombinant Rat Il1rn protein E.coli N/A Inquiry
    Rat Il1rn-8709R Recombinant Rat Il1rn, Fc tagged Human Cell Fc Inquiry
    Cynomolgus Monkey IL1RN-615C Recombinant Cynomolgus IL1RN Protein, His-tagged Mammalian Cell His Inquiry
    Dog IL1RN-249D Recombinant Dog IL1RN Protein, His-tagged E.coli His Inquiry
    Rabbit IL1RN-254R Recombinant Rabbit IL1RN Protein, His-tagged E.coli His Inquiry
    Chicken IL1RN-4645C Recombinant Chicken IL1RN Mammalian Cell His Inquiry
    Cattle IL1RN-248C Recombinant Cattle IL1RN Protein, His-tagged E.coli His Inquiry
    Horse IL1RN-250H Recombinant Horse IL1RN Protein, His-tagged E.coli His Inquiry
    Pig IL1RN-253P Recombinant Pig IL1RN Protein, His-tagged E.coli His Inquiry
    Rhesus monkey (Simian) IL1RN-255R Recombinant Rhesus monkey IL1RN Protein, His-tagged E.coli His Inquiry
    Horse IL1RN-602H Recombinant Horse IL1RN protein E.coli N/A Inquiry
    Pig IL1RN-89P Recombinant Pig IL1RN protein E.coli N/A Inquiry
    Human IL1RN-2912HCL Recombinant Human IL1RN cell lysate Human Cell N/A Inquiry
    Rat IL1RN-1375RCL Recombinant Rat IL1RN cell lysate Human Cell N/A Inquiry
    Cynomolgus IL1RN-094C Recombinant Cynomolgus IL1RN protein, His-tagged E.coli His Inquiry
    Rat IL1RN-103R Recombinant Rat IL1RN Protein, His-tagged HEK293 His Inquiry
    Human IL1RN-104H Recombinant Human IL1RN Protein E.coli Inquiry
    Cynomolgus IL1RN-10C Recombinant Cynomolgus IL1RN Protein, His-tagged HEK293 His Inquiry
    Human IL1RN-153H Recombinant Human IL1RN Protein E.coli Inquiry
    Human IL1RN-167H Recombinant Active Human IL1RN Protein, His-tagged(C-ter) E.coli His(C-ter) Inquiry
    Mouse Il1rn-168M Recombinant Active Mouse IL1RN Protein, His-tagged(C-ter) E.coli His(C-ter) Inquiry
    Human IL1RN-1893HFL Recombinant Full Length Human IL1RN Protein, C-Flag-tagged Mammalian cells Flag Inquiry
    Rat Il1rn-2299R Recombinant Rat Il1rn Protein, His-tagged E.coli N-His Inquiry
    Human IL1RN-3596H Recombinant Human IL1RN protein, His-tagged E.coli His Inquiry
    Human DMABT-H18692 Mouse Anti-IL1RN Monoclonal Antibody Mouse N/A Inquiry
    Human IL1RN-121H Human Interleukin-1 Receptor Antagonist(rDNA derived) Reference standard N/A Inquiry
    Human IL1RN-1819H Recombinant Human IL1RN Protein, MYC/DDK-tagged HEK293 Myc/DDK Inquiry
    Human IL1RN-3350H Recombinant Human IL1RN Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK Inquiry
    Human IL1RN-3569H Recombinant Human IL1RN Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK Inquiry
    Human IL1RN-5230H Recombinant Human IL1RN Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK Inquiry
    Human IL1RN-P038H Recombinant Human IL1RN therapeutic protein E.coli N/A Inquiry
    Mouse Il1rn-1244M Recombinant Mouse Il1rn Protein, MYC/DDK-tagged HEK293T MYC/DDK Inquiry
    Rabbit IL1RN-4363R Recombinant Rabbit IL1RN Protein Yeast N/A Inquiry

    Il1rn involved in several pathways and played different roles in them. We selected most pathways Il1rn participated on our site, such as Cytokine Signaling in Immune system, IL-1 Signaling Pathway, IL1-mediated signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il1rn were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine Signaling in Immune system TRIM6; IFIT11; IFIT14; IRAK3; NOD1; TRIM5; PELI2; UBE2L6; IRF9; JAK3
    IL-1 Signaling Pathway IKBKAP; SIRPA; IL1RN
    IL1-mediated signaling events TMEM189-UBE2V1; TMED7-TICAM2; IL1RN; IRAK3
    Immune System KLHL20; CD300LB; FAM49BA; IFI16; BTR30; PPIAL4A; CMTM2A; CLEC2H; EGR1; XAF1
    Interleukin-1 signaling IL1RN; PELI3; IRAK3; PELI1; NOD1; TNIP2; PELI2
    Leptin signaling pathway IL1RN; CFL2; KHDRBS1
    SIDS Susceptibility Pathways LMX1B; FOXM1; POU2F2; MAZ; PHOX2A; TSPYL1; CTCF; TPH2; ASCL1; SCN3B
    Signaling by Interleukins SOCS3A; LGALS9; CASPB; HAVCR2; IL1RN; CASPBL

    Il1rn has several biochemical functions, for example, cytokine activity, interleukin-1 Type I receptor antagonist activity, interleukin-1 Type II receptor antagonist activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Il1rn itself. We selected most functions Il1rn had, and list some proteins which have the same functions with Il1rn. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity TGFB1A; CSF2; IL21; FLT3LG; GRN; SP100; TSLP; CCL4; CSF1B; GPI1
    interleukin-1 Type I receptor antagonist activity IL1RN
    interleukin-1 Type II receptor antagonist activity IL1RN
    interleukin-1 receptor antagonist activity IL36RN; IL1RN; Il1f5
    interleukin-1 receptor binding IL37; IL1RAP; IL36B; IL36G; IL1F10; IRAK1; IL36A; TLR9; Il1f6; IL1A
    interleukin-1, Type I receptor binding TOLLIP; IL1RN
    interleukin-1, Type II receptor binding IL1RN; ERAP1
    protein binding IP6K2; PHF23; CYSLTR1; LRRFIP2; DRD3; SMR3B; SNAPC3; CTNNBL1; SIGLEC5; DHX30

    Il1rn has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il1rn here. Most of them are supplied by our site. Hope this information will be useful for your research of Il1rn.

    TERF2IP; IL1R1; POT1

    Levin, EC; Debbaneh, M; et al. Biologic Therapy in Erythrodermic and Pustular Psoriasis. JOURNAL OF DRUGS IN DERMATOLOGY 13:342-354(2014).
    Zaaber, I; Mestiri, S; et al. Polymorphisms in TSHR and IL1RN genes and the risk and prognosis of Hashimoto's thyroiditis. AUTOIMMUNITY 47:113-118(2014).

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