The interleukin-1 receptor antagonist (IL-1RA) is a protein that in humans is encoded by the IL1RN gene. IL-1RA was initially called the IL-1 inhibitor and was discovered separately in 1984 by two independent laboratories. IL-1RA, is an agent that binds non-productively to the cell surface interleukin-1 receptor (IL-1R). IL-1R is the same receptor that binds interleukin 1 (IL-1). Hence IL-1RA prevents IL-1 from sending a signal to that cell.
Il1rn involved in several pathways and played different roles in them. We selected most pathways Il1rn participated on our site, such as Cytokine Signaling in Immune system, IL-1 Signaling Pathway, IL1-mediated signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il1rn were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Il1rn has several biochemical functions, for example, cytokine activity, interleukin-1 Type I receptor antagonist activity, interleukin-1 Type II receptor antagonist activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Il1rn itself. We selected most functions Il1rn had, and list some proteins which have the same functions with Il1rn. You can find most of the proteins on our site.
interleukin-1 Type I receptor antagonist activity
interleukin-1 Type II receptor antagonist activity
Il1rn has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il1rn here. Most of them are supplied by our site. Hope this information will be useful for your research of Il1rn.
TERF2IP; IL1R1; POT1
Levin, EC; Debbaneh, M; et al. Biologic Therapy in Erythrodermic and Pustular Psoriasis. JOURNAL OF DRUGS IN DERMATOLOGY 13:342-354(2014).
Zaaber, I; Mestiri, S; et al. Polymorphisms in TSHR and IL1RN genes and the risk and prognosis of Hashimoto's thyroiditis. AUTOIMMUNITY 47:113-118(2014).