il1rn
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  • Official Full Name
  • interleukin 1 receptor antagonist
  • Background
  • The interleukin-1 receptor antagonist (IL-1RA) is a protein that in humans is encoded by the IL1RN gene. IL-1RA was initially called the IL-1 inhibitor and was discovered separately in 1984 by two independent laboratories. IL-1RA, is an agent that binds non-productively to the cell surface interleukin-1 receptor (IL-1R). IL-1R is the same receptor that binds interleukin 1 (IL-1). Hence IL-1RA prevents IL-1 from sending a signal to that cell.
  • Synonyms
  • IL1RN; interleukin 1 receptor antagonist; interleukin-1 receptor antagonist protein; ICIL 1RA; IL 1RN; IL1F3; IL1RA; interleukin 1 receptor antagonist protein; intracellular interleukin 1 receptor antagonist; IRAP; MGC10430; IL1 inhibitor; IL1RN (IL1F3); type II interleukin-1 receptor antagonist; intracellular IL-1 receptor antagonist type II; intracellular interleukin-1 receptor antagonist (icIL-1ra); DIRA; MVCD4; IL-1RN; IL-1ra; IL-1ra3; ICIL-1RA
Cat.#:IL1RN-1819HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL1RN Protein, MYC/DDK-tagged
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Cat.#:IL1RN-4363RTag:
Source (Host):YeastSpecies:Rabbit
Product nameRecombinant Rabbit IL1RN Protein
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Cat.#:IL1RN-188HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL1RN Protein
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Cat.#:IL1RN-28733THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL1RN, His-tagged
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Cat.#:IL1RN-314HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL1RN, Fc tagged
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Cat.#:IL1RN-495HTag:His
Source (Host):HEK293FSpecies:Human
Product nameRecombinant Human IL1RN protein, His-tagged
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Cat.#:Il1rn-15856MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il1rn, His-tagged
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Cat.#:Il1rn-546MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il1rn
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Cat.#:Il1rn-5593MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Interleukin 1 Receptor Antagonist, His-tagged
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Cat.#:Il1rn-107RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Il1rn, His-tagged
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Cat.#:IL1RN-3037RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat IL1RN Protein
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Cat.#:Il1rn-574RTag:
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Il1rn
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Cat.#:Il1rn-8709RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Il1rn, Fc tagged
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Cat.#:IL1RN-615CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IL1RN Protein, His-tagged
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Cat.#:IL1RN-249DTag:His
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog IL1RN Protein, His-tagged
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Cat.#:IL1RN-254RTag:His
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit IL1RN Protein, His-tagged
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Cat.#:IL1RN-4645CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IL1RN
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Cat.#:IL1RN-248CTag:His
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle IL1RN Protein, His-tagged
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Cat.#:IL1RN-250HTag:His
Source (Host):E. coliSpecies:Horse
Product nameRecombinant Horse IL1RN Protein, His-tagged
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Cat.#:IL1RN-253PTag:His
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig IL1RN Protein, His-tagged
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Cat.#:IL1RN-255RTag:His
Source (Host):E. coliSpecies:Rhesus monkey (Simian)
Product nameRecombinant Rhesus monkey IL1RN Protein, His-tagged
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Cat.#:IL1RN-602HTag:
Source (Host):E. coliSpecies:Equine
Product nameRecombinant Horse IL1RN
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Cat.#:IL1RN-89PTag:N/A
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Porcine IL1RN
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Cat.#:IL1RN-945ETag:Met
Source (Host):E. coliSpecies:Equine
Product nameRecombinant Equine IL1RN
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Cat.#:IL1RN-05HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin-1 Receptor Antagonist
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Cat.#:IL1RN-115HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Interleukin 1 Receptor Antagonist
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Cat.#:IL1RN-51HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin 1 Receptor Antagonist, His-tagged
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Cat.#:Il1rn-231MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Interleukin-1 Receptor Antagonist
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Cat.#:IL1RN-2912HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL1RN cell lysate
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Cat.#:IL1RN-1375RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat IL1RN cell lysate
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Cat.#:IL1RN-121HTag:
Source (Host):Species:Human
Product nameHuman Interleukin-1 Receptor Antagonist(rDNA derived) Reference standard
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Cat.#:IL1RN-P038HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL1RN therapeutic protein
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Involved Pathway

Il1rn involved in several pathways and played different roles in them. We selected most pathways Il1rn participated on our site, such as Cytokine Signaling in Immune system, IL-1 Signaling Pathway, IL1-mediated signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il1rn were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine Signaling in Immune system
IFI27; DUSP7; MAP3K8; HERC5; ADAR; SPRED1; IFIT2; TRIM29; HAVCR2; KLB
IL-1 Signaling Pathway
IKBKAP; IL1RN; SIRPA
IL1-mediated signaling events
TMED7-TICAM2; TMEM189-UBE2V1; IL1RN; IRAK3
Immune System
KIF2C; DEFB4A; TRIM68; KIR3DS1; DDX41; CD200; DEFB106A; GM11711; ABI1A; TRIM2
Interleukin-1 signaling
PELI1; IRAK3; PELI3; TNIP2; IL1RN; NOD1; PELI2
Leptin signaling pathway
CFL2; IL1RN; KHDRBS1
SIDS Susceptibility Pathways
IL1RN; DLX2; TAC1; TSPYL1; SP3; SCN3B; KCNJ8; YBX1; PHOX2A; ECE1
Signaling by Interleukins
HAVCR2; IL1RN; LGALS9; CASPBL; SOCS3A; CASPB

Protein Function

Il1rn has several biochemical functions, for example, cytokine activity, interleukin-1 Type I receptor antagonist activity, interleukin-1 Type II receptor antagonist activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Il1rn itself. We selected most functions Il1rn had, and list some proteins which have the same functions with Il1rn. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein IL13; IL29; IFNA7; IL21; IFNT2; FGF2; CCL4; IL4; IFNG1-1; TNFSF13B
Function interleukin-1 Type I receptor antagonist activity
Related Protein IL1RN
Function interleukin-1 Type II receptor antagonist activity
Related Protein IL1RN
Function interleukin-1 receptor antagonist activity
Related Protein IL36RN; Il1f5; IL1RN
Function interleukin-1 receptor binding
Related Protein TRIP6; IL1F10; IRAK1; IL36B; IRAK4; Il1f6; IL36RN; IL37; IL1A; TLR9
Function interleukin-1, Type I receptor binding
Related Protein IL1RN; TOLLIP
Function interleukin-1, Type II receptor binding
Related Protein ERAP1; IL1RN
Function protein binding
Related Protein CTPS2; FMO4; CYB561; SPEG; GRM1; TIMP3; UBLCP1; TNFSF12; CBLB; STON2

Interacting Protein

Il1rn has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il1rn here. Most of them are supplied by our site. Hope this information will be useful for your research of Il1rn.
TERF2IP; IL1R1; POT1

Il1rn Related Articles

Levin, EC; Debbaneh, M; et al. Biologic Therapy in Erythrodermic and Pustular Psoriasis. JOURNAL OF DRUGS IN DERMATOLOGY 13:342-354(2014).
Zaaber, I; Mestiri, S; et al. Polymorphisms in TSHR and IL1RN genes and the risk and prognosis of Hashimoto's thyroiditis. AUTOIMMUNITY 47:113-118(2014).

Il1rn Related Gene Family

IL