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Official Full Name interleukin 1 receptor antagonist
Background The interleukin-1 receptor antagonist (IL-1RA) is a protein that in humans is encoded by the IL1RN gene. IL-1RA was initially called the IL-1 inhibitor and was discovered separately in 1984 by two independent laboratories. IL-1RA, is an agent that binds non-productively to the cell surface interleukin-1 receptor (IL-1R). IL-1R is the same receptor that binds interleukin 1 (IL-1). Hence IL-1RA prevents IL-1 from sending a signal to that cell.
Synonyms IL1RN; interleukin 1 receptor antagonist; interleukin-1 receptor antagonist protein; ICIL 1RA; IL 1RN; IL1F3; IL1RA; interleukin 1 receptor antagonist protein; intracellular interleukin 1 receptor antagonist; IRAP; MGC10430; IL1 inhibitor; IL1RN (IL1F3); type II interleukin-1 receptor antagonist; intracellular IL-1 receptor antagonist type II; intracellular interleukin-1 receptor antagonist (icIL-1ra); DIRA; MVCD4; IL-1RN; IL-1ra; IL-1ra3; ICIL-1RA
    • Species :
    • Cattle
    • Chicken
    • Cynomolgus Monkey
    • Dog
    • Equine
    • Horse
    • Human
    • Mouse
    • Pig
    • Rabbit
    • Rat
    • Rhesus monkey (Simian)
    • Source :
    • E.coli
    • HEK293
    • HEK293F
    • HEK293T
    • Human Cell
    • Mammalian Cell
    • Mouse
    • Yeast
    • Tag :
    • Fc
    • His
    • Met
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DMABT-H18692 Mouse Anti-IL1RN Monoclonal Antibody Mouse N/A
    Human IL1RN-05H Recombinant Human IL1RN protein E.coli N/A
    Human IL1RN-115H Recombinant Human Interleukin 1 Receptor Antagonist HEK293 N/A
    Human IL1RN-121H Human Interleukin-1 Receptor Antagonist(rDNA derived) Reference standard N/A
    Human IL1RN-1819H Recombinant Human IL1RN Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human IL1RN-188H Recombinant Human IL1RN Protein E.coli N/A
    Human IL1RN-28733TH Recombinant Human IL1RN, His-tagged E.coli His
    Human IL1RN-2912HCL Recombinant Human IL1RN cell lysate Human Cell N/A
    Human IL1RN-314H Recombinant Human IL1RN, Fc tagged Human Cell Fc
    Human IL1RN-3350H Recombinant Human IL1RN Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human IL1RN-3569H Recombinant Human IL1RN Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human IL1RN-495H Recombinant Human IL1RN protein, His-tagged HEK293F His
    Human IL1RN-51H Recombinant Human Interleukin 1 Receptor Antagonist, His-tagged E.coli His
    Human IL1RN-5230H Recombinant Human IL1RN Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human IL1RN-P038H Recombinant Human IL1RN therapeutic protein E.coli N/A
    Mouse Il1rn-1244M Recombinant Mouse Il1rn Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse Il1rn-15856M Recombinant Mouse Il1rn, His-tagged E.coli His
    Mouse Il1rn-231M Recombinant Mouse Interleukin-1 Receptor Antagonist E.coli N/A
    Mouse Il1rn-546M Recombinant Mouse Il1rn protein E.coli N/A
    Mouse Il1rn-5593M Recombinant Mouse Interleukin 1 Receptor Antagonist, His-tagged E.coli His
    Rat Il1rn-107R Recombinant Rat Il1rn, His-tagged E.coli His
    Rat IL1RN-1375RCL Recombinant Rat IL1RN cell lysate Human Cell N/A
    Rat IL1RN-3037R Recombinant Rat IL1RN Protein Mammalian Cell His
    Rat Il1rn-574R Recombinant Rat Il1rn protein E.coli N/A
    Rat Il1rn-8709R Recombinant Rat Il1rn, Fc tagged Human Cell Fc
    Cynomolgus Monkey IL1RN-615C Recombinant Cynomolgus IL1RN Protein, His-tagged Mammalian Cell His
    Dog IL1RN-249D Recombinant Dog IL1RN Protein, His-tagged E.coli His
    Rabbit IL1RN-254R Recombinant Rabbit IL1RN Protein, His-tagged E.coli His
    Rabbit IL1RN-4363R Recombinant Rabbit IL1RN Protein Yeast N/A
    Chicken IL1RN-4645C Recombinant Chicken IL1RN Mammalian Cell His
    Cattle IL1RN-248C Recombinant Cattle IL1RN Protein, His-tagged E.coli His
    Horse IL1RN-250H Recombinant Horse IL1RN Protein, His-tagged E.coli His
    Pig IL1RN-253P Recombinant Pig IL1RN Protein, His-tagged E.coli His
    Rhesus monkey (Simian) IL1RN-255R Recombinant Rhesus monkey IL1RN Protein, His-tagged E.coli His
    Horse IL1RN-602H Recombinant Horse IL1RN protein E.coli N/A
    Pig IL1RN-89P Recombinant Pig IL1RN protein E.coli N/A
    Equine IL1RN-945E Recombinant Equine IL1RN E.coli Met

    il1rn involved in several pathways and played different roles in them. We selected most pathways il1rn participated on our site, such as Cytokine Signaling in Immune system, IL-1 Signaling Pathway, IL1-mediated signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with il1rn were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine Signaling in Immune system HERC5; IFIT8; RASGRP1; OSTN; CRKL; CISH; UBE2V1; SPNA2; IFIT10; NUPL2
    IL-1 Signaling Pathway IKBKAP; IL1RN; SIRPA
    IL1-mediated signaling events IRAK3; TMEM189-UBE2V1; IL1RN; TMED7-TICAM2
    Immune System PRLRB; XAF1; BTR12; Txn1; SIGLEC12; KIF3C; ABI1B; GBP2; CTSC; IGHM
    Interleukin-1 signaling TNIP2; IL1RN; NOD1; PELI1; PELI2; IRAK3; PELI3
    Leptin signaling pathway CFL2; IL1RN; KHDRBS1
    SIDS Susceptibility Pathways TPH2; SP3; POU3F2; CHRFAM7A; PLP1; KCNJ8; LMX1B; ASCL1; MAZ; TPPP
    Signaling by Interleukins CASPB; SOCS3A; IL1RN; CASPBL; LGALS9; HAVCR2

    il1rn has several biochemical functions, for example, cytokine activity, interleukin-1 Type I receptor antagonist activity, interleukin-1 Type II receptor antagonist activity. Some of the functions are cooperated with other proteins, some of the functions could acted by il1rn itself. We selected most functions il1rn had, and list some proteins which have the same functions with il1rn. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity CXCL9; CCL38.1; C1QTNF4; AREG; IL4; GPI; IL19; IL24; GDF10B; GDF7
    interleukin-1 Type I receptor antagonist activity IL1RN
    interleukin-1 Type II receptor antagonist activity IL1RN
    interleukin-1 receptor antagonist activity IL36RN; Il1f5; IL1RN
    interleukin-1 receptor binding IL1RAP; IL1A; IL1F10; IL37; IRAK1; IL36B; IRAK4; IL36RN; TLR5; Il1f6
    interleukin-1, Type I receptor binding IL1RN; TOLLIP
    interleukin-1, Type II receptor binding ERAP1; IL1RN
    protein binding LCMT2; PYGB; CKMT1; RGS14; SGSM3; TJP1; RXRB; FAM115A; SYCE1; MORN3

    il1rn has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with il1rn here. Most of them are supplied by our site. Hope this information will be useful for your research of il1rn.

    TERF2IP; IL1R1; POT1

    Levin, EC; Debbaneh, M; et al. Biologic Therapy in Erythrodermic and Pustular Psoriasis. JOURNAL OF DRUGS IN DERMATOLOGY 13:342-354(2014).
    Zaaber, I; Mestiri, S; et al. Polymorphisms in TSHR and IL1RN genes and the risk and prognosis of Hashimoto's thyroiditis. AUTOIMMUNITY 47:113-118(2014).


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