Active Recombinant Human IL1RN Protein
|Product Overview :||Recombinant Human Interleukin-1 Receptor Antagonist Protein is produced by our E.coli expression system and the target gene encoding Arg26-Glu177 is expressed.|
- Gene Information
- Related Products
|Description :||Interleukin-1 Receptor Antagonist (IL-1RN) is a member of the IL-1 family. Endogenous IL-1RN is produced in numerous animal disease models as well as in human autoimmune and chronic inflammatory diseases. It binds to IL-1 receptors in competition with IL-1, but does not elicit intracellular response from this binding. Its role in counteracting the proinflammatory effects of IL-1 is being studied by numerous research groups. IL-4 and IL-13 have been shown to amplify the stimulatory effect of IL1-beta on the production of soluble and intracellular forms of IL-1RN. The regulated expression of IL-1RN in various cell types has been shown to be influenced by cytokines. In synovial fibroblasts, IL-1, TNF-alpha, or PDGF markedly enhances the synthesis of IL-1RN.|
|Source :||E. coli|
|Form :||Lyophilized from a 0.2 um filtered solution of 50mM TrisHCl, 200mM NaCl, pH 7.5.|
|Bio-activity :||Measured by the dose-dependent inhibition of IL-1 stimulation of D10S cells. ED50 is 0.5 ng/ml. Specific Activity of 2.0 x 10^6 IU/mg.|
|Protein Length :||Arg26-Glu177|
|AA Sequence :||MRPSGRKSSKMQAFRIWDVNQKTFY LRNNQLVAGYLQGPNVNLEEKIDVV PIEPHALFLGIHGGKM CLSCVKSGDETRLQLEA VNITDLSENRKQDKRFAFIRSDSGP TTSFESAACPGWFLCTAMEADQPVS LTNMPDEGVMVTKFYF QEDE|
|Endotoxin :||Less than 0.1 ng/ug (1 EU/ug).|
|Storage :||Lyophilized protein should be stored at < -20 centigrade, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7 centigrade for 2-7 days.
Aliquots of reconstituted samples are stable at < -20 centigrade for 3 months.
|Quality Statement :||Purity: Greater than 95% as determined by reducing SDS-PAGE.|
|Shipping :||The product is shipped at ambient temperature.
Upon receipt, store it immediately at the temperature listed below.
|Gene Name :||IL1RN interleukin 1 receptor antagonist [ Homo sapiens (human) ]|
|Official Symbol :||IL1RN|
|Synonyms :||Interleukin-1 Receptor Antagonist Protein; IL-1RN; IL-1ra; IRAP; ICIL-1RA; IL1 Inhibitor; Anakinra; DIRA; IRAP; IL1F3; IL1RA; MVCD4; IL-1ra3|
|Gene ID :||3557|
|mRNA Refseq :||NM_000577.5|
|Protein Refseq :||NP_000568.1|
|UniProt ID :||P18510|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.