Active Recombinant Human IL22 Protein (146 aa)
| Cat.No. : | IL22-098I |
| Product Overview : | Recombinant Human IL22 Protein without tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
| Description : | IL-22 is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10R-β/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family. |
| Source : | E. coli |
| Species : | Human |
| Form : | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Bio-activity : | Determined by its ability to activate STAT following receptor ligand interaction. |
| Molecular Mass : | Approximately 33.6 kDa,non-disulfide-linked homodimeric protein containing of two 146 amino acid polypeptide chains. |
| Protein Length : | 146 |
| AA Sequence : | MAPISSHCRLDKSNFQQPYITNRTF MLAKEASLADNNTDVRLIGEKLFHG VSMSERCYLMKQVLNFTLEEVLFPQ SDRFQPYMQEVVPFLARLSNRLSTC HIEGDDLHIQRNVQKLKDTVKKLGE SGEIKAIGELDLLFMSLRNACI |
| Endotoxin : | Less than 1 EU/mg of rHuIL-22 as determined by LAL method. |
| Purity : | >97% by SDS-PAGE and HPLC analyses. |
| Storage : | This lyophilized preparation is stable at 2-8 centigrade, but should be kept at -20 centigrade for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 centigrade. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 to -70 centigrade. Avoid repeated freeze/thaw cycles. |
| Storage Buffer : | Lyophilized from a 0.2mm filtered concentrated solution in PBS, pH 5.0. |
| Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 centigrade. Further dilutions should be made in appropriate buffered solutions. |
| Gene Name : | IL22 interleukin 22 [ Homo sapiens ] |
| Official Symbol : | IL22 |
| Synonyms : | IL22; interleukin 22; interleukin-22; IL 10 related T cell derived inducible factor; IL 21; IL 22; IL D110; IL TIF; ILTIF; MGC79382; MGC79384; TIFa; TIFIL 23; zcyto18; cytokine Zcyto18; IL-10-related T-cell-derived inducible factor; IL-10-related T-cell-derived-inducible factor; IL-21; IL-22; IL-TIF; IL-D110; TIFIL-23; |
| Gene ID : | 50616 |
| mRNA Refseq : | NM_020525 |
| Protein Refseq : | NP_065386 |
| MIM : | 605330 |
| UniProt ID : | Q9GZX6 |
Products Types
| ◆ Recombinant Protein | ||
| IL22-2066R | Recombinant Rhesus Macaque IL22 Protein, His (Fc)-Avi-tagged | +Inquiry |
| Il22-1673R | Recombinant Rat Il22 Protein, His-tagged | +Inquiry |
| IL22-360I | Active Recombinant Human IL22 Protein (147 aa) | +Inquiry |
| IL22-241H | Active Recombinant Human IL22 Protein (Ala34-Ile179), C-His tagged, Animal-free, Carrier-free | +Inquiry |
| IL22-512H | Recombinant Human IL22 Protein | +Inquiry |
| ◆ Lysates | ||
| IL22-5232HCL | Recombinant Human IL22 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (10)
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What is IL22's role in gut epithelial repair?
02/05/2022
IL22 enhances gut epithelial repair mechanisms.
What are the downstream targets of IL22 signaling?
12/27/2021
IL22 activates STAT3 to modulate downstream targets.
How does IL22 interact with other cytokines in inflammation?
10/06/2021
IL22 interacts synergistically with IL-17 during inflammation.
Is IL22 involved in the pathogenesis of autoimmune diseases?
06/25/2021
IL22 is involved in the pathogenesis of autoimmune diseases like Crohn's.
Does IL22 have a role in metabolic syndrome?
02/23/2021
IL22 is implicated in metabolic syndrome by affecting insulin sensitivity.
How is IL22 expression regulated in psoriasis?
09/05/2018
IL22 expression is upregulated in psoriasis.
Does IL22 expression change during viral infections?
07/26/2018
IL22 expression is upregulated during viral infections like Hepatitis C.
Does IL22 contribute to anti-tumor immunity?
03/14/2018
IL22 contributes to anti-tumor immunity by activating NK cells.
How does IL22 modulate T-cell differentiation?
10/30/2017
IL22 promotes Th22 cell differentiation.
What impact do IL22 polymorphisms have on its function?
09/25/2017
IL22 polymorphisms affect its binding affinity and signaling.
Customer Reviews (3)
Write a reviewReviews
04/07/2021
High specificity. -
03/29/2021
Good for Th17 differentiation. -
07/07/2016
Effective in gut repair assays. -
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