Recombinant Human Interleukin 22

Cat.No. : IL22-555H
Product Overview : IL22 HumanRecombinant produced in E. Coli is a single, non-glycosylated homodimericpolypeptide chain containing 2 x 146 amino acids and having a total MW 33.607kDalton.
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Cat. No. : IL22-555H
Description : Interleukin-22 (IL22)is protein that in humans is encoded by the IL22 gene. IL22 a member of agroup of cytokines called the IL-10 family or IL-10 superfamily (includingIL-19, IL-20, IL-24, and IL-26), a class of potent mediators of cellular inflammatoryresponses. It shares use of IL-10R2 in cell signaling with other members ofthis family, IL-10, IL-26, IL-28A/B and IL-29.
Source : Human
Host : E. coli
Form : Lyophilized.Each mg contains 1.6 mg mannitol and 1.2 mg HSA.
Purity : Greater than 97.0%by SDS-PAGE gel and RF-HPLC.
Sequence : The sequence of thefirst five N-terminal amino acids is Met-Ala-Pro-Ile-Ser.
Molecular Weight : 33.607kDalton
Biological Activity : BiologicalAcitivity was determined by the ability to activiate STAT following receptor ligandinteraction.
Endotoxin Level : Less than0.1 ng per µg (1 EU/µg) of protein.
Reconstitution : Centrifugevial prior to opening. First add sterile water to the vial to fullysolubilize the protein to a concentration not less than 100 µg/ml. After completesolubilization of the protein, it can be further diluted to other aqueoussolutions.
Storage : Lyophilizedsamples are stable at room temperature for 3 weeks, but it is recommended tostore them desiccated at -20°C to -80°C. Upon reconstitution, protein shouldbe stored at 2-4°C for one week and for six months at -20°C to -80°C. Add acarrier protein (0.1% HSA or BSA) as a stabilizer for long term storage.Avoid repeated freeze-thaw cycles.
OfficialSymbol : IL22
Gene Name : IL22interleukin 22 [ Homo sapiens ]
Synonyms : IL22; interleukin 22; TIFa; IL21; IL-21; IL-22; ILTIF; IL-TIF;IL-D110; zcyto18;ZCYTO183; MGC79382; MGC79384; TIFIL-23; interleukin 21;interleukin-22;cytokine Zcyto18; OTTHUMP00000240117; IL-10-related T-cell-derived induciblefactor; IL-10-related T-cell-derived-inducible factor
Gene ID : 50616
mRNA Refseq : NM_020525
Protein Refseq : NP_065386
MIM : 605330
UniProt ID : Q9GZX6
Chromosome Location : 12q15
Pathway : Cytokine-cytokinereceptor interaction; Jak-STAT signaling pathway
Function : cytokineactivity; interleukin-22 receptor binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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Q&As (10)

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What is IL22's role in gut epithelial repair? 02/05/2022

IL22 enhances gut epithelial repair mechanisms.

What are the downstream targets of IL22 signaling? 12/27/2021

IL22 activates STAT3 to modulate downstream targets.

How does IL22 interact with other cytokines in inflammation? 10/06/2021

IL22 interacts synergistically with IL-17 during inflammation.

Is IL22 involved in the pathogenesis of autoimmune diseases? 06/25/2021

IL22 is involved in the pathogenesis of autoimmune diseases like Crohn's.

Does IL22 have a role in metabolic syndrome? 02/23/2021

IL22 is implicated in metabolic syndrome by affecting insulin sensitivity.

How is IL22 expression regulated in psoriasis? 09/05/2018

IL22 expression is upregulated in psoriasis.

Does IL22 expression change during viral infections? 07/26/2018

IL22 expression is upregulated during viral infections like Hepatitis C.

Does IL22 contribute to anti-tumor immunity? 03/14/2018

IL22 contributes to anti-tumor immunity by activating NK cells.

How does IL22 modulate T-cell differentiation? 10/30/2017

IL22 promotes Th22 cell differentiation.

What impact do IL22 polymorphisms have on its function? 09/25/2017

IL22 polymorphisms affect its binding affinity and signaling.

Customer Reviews (3)

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    High specificity. -


      Good for Th17 differentiation. -


        Effective in gut repair assays. -

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