Recombinant Human Interleukin 22

• Cat.No.: IL22-555H
• Product Overview: IL22 HumanRecombinant produced in E. Coli is a single, non-glycosylated homodimericpolypeptide chain containing 2 x 146 amino acids and having a total MW 33.607kDalton.

Specification

• Cat. No.: IL22-555H
• Description: Interleukin-22 (IL22)is protein that in humans is encoded by the IL22 gene. IL22 a member of agroup of cytokines called the IL-10 family or IL-10 superfamily (includingIL-19, IL-20, IL-24, and IL-26), a class of potent mediators of cellular inflammatoryresponses. It shares use of IL-10R2 in cell signaling with other members ofthis family, IL-10, IL-26, IL-28A/B and IL-29.
• Source: Human
• Host: E. coli
• Form: Lyophilized.Each mg contains 1.6 mg mannitol and 1.2 mg HSA.
• Purity: Greater than 97.0%by SDS-PAGE gel and RF-HPLC.
• Sequence: The sequence of thefirst five N-terminal amino acids is Met-Ala-Pro-Ile-Ser.
• Molecular Weight: 33.607kDalton
• Biological Activity: BiologicalAcitivity was determined by the ability to activiate STAT following receptor ligandinteraction.
• Endotoxin Level: Less than0.1 ng per µg (1 EU/µg) of protein.
• Reconstitution: Centrifugevial prior to opening. First add sterile water to the vial to fullysolubilize the protein to a concentration not less than 100 µg/ml. After completesolubilization of the protein, it can be further diluted to other aqueoussolutions.
• Storage: Lyophilizedsamples are stable at room temperature for 3 weeks, but it is recommended tostore them desiccated at -20°C to -80°C. Upon reconstitution, protein shouldbe stored at 2-4°C for one week and for six months at -20°C to -80°C. Add acarrier protein (0.1% HSA or BSA) as a stabilizer for long term storage.Avoid repeated freeze-thaw cycles.
• OfficialSymbol: IL22
• Tag: Non

Gene Information

• Gene Name: IL22interleukin 22 [ Homo sapiens ]
• Synonyms: IL22; interleukin 22; TIFa; IL21; IL-21; IL-22; ILTIF; IL-TIF;IL-D110; zcyto18;ZCYTO183; MGC79382; MGC79384; TIFIL-23; interleukin 21;interleukin-22;cytokine Zcyto18; OTTHUMP00000240117; IL-10-related T-cell-derived induciblefactor; IL-10-related T-cell-derived-inducible factor
• Gene ID: 50616
• mRNA Refseq: NM_020525
• Protein Refseq: NP_065386
• MIM: 605330
• UniProt ID: Q9GZX6
• Chromosome Location: 12q15
• Pathway: Cytokine-cytokinereceptor interaction; Jak-STAT signaling pathway
• Function: cytokineactivity; interleukin-22 receptor binding

Reviews

04/07/2021

High specificity.

03/29/2021

Good for Th17 differentiation.

07/07/2016

Effective in gut repair assays.

Q&As

What is IL22's role in gut epithelial repair?

IL22 enhances gut epithelial repair mechanisms.

What are the downstream targets of IL22 signaling?

IL22 activates STAT3 to modulate downstream targets.

How does IL22 interact with other cytokines in inflammation?

IL22 interacts synergistically with IL-17 during inflammation.

Is IL22 involved in the pathogenesis of autoimmune diseases?

IL22 is involved in the pathogenesis of autoimmune diseases like Crohn's.

Does IL22 have a role in metabolic syndrome?

IL22 is implicated in metabolic syndrome by affecting insulin sensitivity.

How is IL22 expression regulated in psoriasis?

IL22 expression is upregulated in psoriasis.

Does IL22 expression change during viral infections?

IL22 expression is upregulated during viral infections like Hepatitis C.

Does IL22 contribute to anti-tumor immunity?

IL22 contributes to anti-tumor immunity by activating NK cells.

How does IL22 modulate T-cell differentiation?

IL22 promotes Th22 cell differentiation.

What impact do IL22 polymorphisms have on its function?

IL22 polymorphisms affect its binding affinity and signaling.