Active Recombinant Human IL33 protein
Cat.No. : | IL33-215H |
Product Overview : | Recombinant Human IL33(Ser 112-Thr 270) fused with an initial Met at the N-terminus was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | Interleukin 33 (IL-33), also known as DVS27 or NF-HEV (Nuclear Factor from High Endothelial enules), is a proinflammatory protein and a chromatin-associated cytokine of the IL-1 family with high sequence and structural similarity to IL-1 and IL-18. IL-33 protein is expressed highly and rather selectively by high endothelial venule endothelial cells (HEVECs) in human tonsils, Peyers's patches, and lymph nodes. IL-33 protein has transcriptional regulatory properties, and the researches suggested that IL-33 is a dual-function protein that might act both as a cytokine and as an intracellular nuclear factor. As a type 2 cytokines, IL-33 protein also play a pivotal role in helminthic infection and allergic disorders. |
Source : | E. coli |
Species : | Human |
Predicted N Terminal : | Met |
Form : | Lyophilized from sterile PBS, pH 7.4. |
Bio-activity : | 1. Measured by its binding ability in a functional ELISA. Immobilized human IL-33 at 10 μg/ml (100 μl/well) can bind human IL1RL1 with a linear range of 0.31-5 ng/ml. 2. Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells costimulated with anti-CD3. The ED50 for this effect is typically 0.15-0.6 ng/mL. |
Molecular Mass : | The recombinant human IL33 comprises 160 amino acids and predicts a molecular mass of 18 kDa as estimated in SDS-PAGE under reducing conditions. |
Purity : | > 98 % as determined by SDS-PAGE |
Stability : | Samples are stable for up to twelve months from date of receipt at -70 centigrade |
Storage : | Store it under sterile conditions at -20centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Gene Name : | IL33 interleukin 33 [ Homo sapiens ] |
Official Symbol : | IL33 |
Synonyms : | IL33; interleukin 33; C9orf26, chromosome 9 open reading frame 26 (NF HEV); interleukin-33; DKFZp586H0523; DVS27; DVS27 related protein; IL1F11; interleukin 1 family; member 11; NF HEV; nuclear factor for high endothelial venules; IL-33; IL-1F11; DVS27-related protein; interleukin-1 family member 11; nuclear factor from high endothelial venules; NF-HEV; NFEHEV; C9orf26; RP11-575C20.2; |
Gene ID : | 90865 |
mRNA Refseq : | NM_033439 |
Protein Refseq : | NP_254274 |
MIM : | 608678 |
UniProt ID : | O95760 |
Chromosome Location : | 9p24.1 |
Pathway : | Cytosolic DNA-sensing pathway, organism-specific biosystem; Cytosolic DNA-sensing pathway, conserved biosystem; Influenza A, organism-specific biosystem; Influenza A, conserved biosystem; |
Function : | cytokine activity; protein binding; |
Products Types
◆ Recombinant Protein | ||
Il33-192M | Recombinant Active Mouse IL33 Protein, His-tagged(C-ter) | +Inquiry |
IL33-1917M | Recombinant Mouse IL33 Protein | +Inquiry |
Il33-1679M | Recombinant Mouse Il33 Protein, His-tagged | +Inquiry |
IL33-175M | Active Recombinant Mouse IL33 Protein | +Inquiry |
IL33-356I | Active Recombinant Human IL33 Protein (159 aa) | +Inquiry |
◆ Lysates | ||
IL33-5226HCL | Recombinant Human IL33 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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