Active Recombinant Human SRC protein, His-tagged

Cat.No. : SRC-533H
Product Overview : Recombinant Human SRC fused with His tag at N-terminal was expressed in Insect cells.
  • Specification
  • Gene Information
  • Related Products
  • Download
Description : This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
Source : Insect cells
Species : Human
Tag : His
Form : 25 mM Tris-HCl, pH 8.0, 69 mM NaCl, 1.35 mM KCl, 0.025% Tween-20, 125 mM imidazole, 50% glycerol, and 3 mM DTT
Bio-activity : 205 pmol/min/μg
Molecular Mass : 60.5 kDa
Purity : >85%
Applications : Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Storage : >6 months at –80 centigrade. Avoid freeze/thaw cycles.
Concentration : 1.2 mg/ml
Publication :
C-terminal Src kinase (Csk) regulates the tricellular junction protein Gliotactin independent of Src. (2017)
Gene Name : SRC SRC proto-oncogene, non-receptor tyrosine kinase [ Homo sapiens ]
Official Symbol : SRC
Synonyms : ASV; SRC1; THC6; c-SRC; p60-Src; proto-oncogene c-Src; protooncogene SRC, Rous sarcoma; tyrosine kinase pp60c-src; tyrosine-protein kinase SRC-1; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
Gene ID : 6714
mRNA Refseq : NM_005417
Protein Refseq : NP_005408
MIM : 190090
UniProt ID : P12931

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Reviews
  • Q&As

Customer Reviews (3)

Write a review
Reviews
01/01/2022

    Top-notch protein purification service, essential for our research.

    08/29/2019

      Reliable mass spectrometry analysis, pivotal for our proteomics work.

      03/02/2019

        Swift and reliable protein sequencing, indispensable for our research success.

        Q&As (7)

        Ask a question
        How do alterations in SRC expression or activity affect the development of drug resistance in tumors? 10/23/2022

        Changes in SRC expression or kinase activity can lead to drug resistance in cancer treatment.

        How does SRC (proto-oncogene tyrosine-protein kinase Src) regulate cell proliferation and survival? 07/08/2021

        SRC regulates cell proliferation and survival through its kinase activity, influencing various signaling pathways.

        How does SRC contribute to the regulation of bone remodeling and osteoclast activity? 06/26/2020

        SRC is involved in bone remodeling, regulating osteoclast activity and bone resorption.

        What role does SRC play in cancer development and progression, particularly in metastasis? 03/16/2020

        SRC plays a crucial role in cancer progression, particularly in enhancing metastatic potential of tumor cells.

        How does SRC influence cellular signaling pathways, such as the Ras/MAPK and PI3K/Akt pathways? 12/06/2019

        SRC influences key cellular signaling pathways like Ras/MAPK and PI3K/Akt, affecting cell growth and survival.

        What are the mechanisms by which SRC modulates cellular adhesion and migration? 03/27/2019

        SRC modulates cellular adhesion and migration, playing a role in tissue repair and cancer metastasis.

        What is the impact of SRC inhibition on targeted cancer therapies? 01/02/2018

        SRC inhibition is a target in cancer therapy, potentially reducing tumor growth and metastasis.

        Ask a Question for All SRC Products

        Required fields are marked with *

        My Review for All SRC Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /
        • Service lnquiry:

        Stay Updated on the Latest Bioscience Trends