Recombinant Human SRC, GST-tagged

• Cat.No.: SRC-3824H
• Product Overview: Recombinant Human SRC was expressed as gst-tagged fusion protein by E.Coli and puri?ed by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: False
• Description: This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
• AA Sequence: C-term-350aa
• Storage: The protein is stored in PBS bu?er at -20 oC. Repeated freeze-thaw cycles should be avoided.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: SRC v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog [ Homo sapiens (human) ]
• Official Symbol: SRC
• Synonyms: SRC; ASV; SRC1; c-SRC; p60-Src; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog; proto-oncogene tyrosine-protein kinase Src; proto-oncogene c-Src; tyrosine kinase pp60c-src; tyrosine-protein kinase SRC-1; protooncogene SRC, Rous sarcoma; NP_005408.1; EC 2.7.10.2; NP_938033.1
• Gene ID: 6714
• mRNA Refseq: NM_005417
• Protein Refseq: NP_005408
• MIM: 190090
• UniProt ID: P12931
• Chromosome Location: 20q12-q13
• Pathway: ADP signalling through P2Y purinoceptor 1; AGE/RAGE pathway; Alpha-synuclein signaling
• Function: ATP binding; SH3/SH2 adaptor activity; ephrin receptor binding