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Recombinant Human SRC, GST-tagged

Cat.No. : SRC-3824H
Product Overview : Recombinant Human SRC was expressed as gst-tagged fusion protein by E.Coli and puri?ed by GSH-sepharose.
Availability February 10, 2025
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Description : This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
Source : E.coli
Species : Human
Tag : GST
Protein length : False
AA Sequence : C-term-350aa
Storage : The protein is stored in PBS bu?er at -20 oC. Repeated freeze-thaw cycles should be avoided.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : SRC v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog [ Homo sapiens (human) ]
Official Symbol : SRC
Synonyms : SRC; ASV; SRC1; c-SRC; p60-Src; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog; proto-oncogene tyrosine-protein kinase Src; proto-oncogene c-Src; tyrosine kinase pp60c-src; tyrosine-protein kinase SRC-1; protooncogene SRC, Rous sarcoma; NP_005408.1; EC 2.7.10.2; NP_938033.1
Gene ID : 6714
mRNA Refseq : NM_005417
Protein Refseq : NP_005408
MIM : 190090
UniProt ID : P12931
Chromosome Location : 20q12-q13
Pathway : ADP signalling through P2Y purinoceptor 1; AGE/RAGE pathway; Alpha-synuclein signaling
Function : ATP binding; SH3/SH2 adaptor activity; ephrin receptor binding

Not For Human Consumption!

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01/01/2022

    Top-notch protein purification service, essential for our research.

    08/29/2019

      Reliable mass spectrometry analysis, pivotal for our proteomics work.

      03/02/2019

        Swift and reliable protein sequencing, indispensable for our research success.

        Q&As (7)

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        How do alterations in SRC expression or activity affect the development of drug resistance in tumors? 10/23/2022

        Changes in SRC expression or kinase activity can lead to drug resistance in cancer treatment.

        How does SRC (proto-oncogene tyrosine-protein kinase Src) regulate cell proliferation and survival? 07/08/2021

        SRC regulates cell proliferation and survival through its kinase activity, influencing various signaling pathways.

        How does SRC contribute to the regulation of bone remodeling and osteoclast activity? 06/26/2020

        SRC is involved in bone remodeling, regulating osteoclast activity and bone resorption.

        What role does SRC play in cancer development and progression, particularly in metastasis? 03/16/2020

        SRC plays a crucial role in cancer progression, particularly in enhancing metastatic potential of tumor cells.

        How does SRC influence cellular signaling pathways, such as the Ras/MAPK and PI3K/Akt pathways? 12/06/2019

        SRC influences key cellular signaling pathways like Ras/MAPK and PI3K/Akt, affecting cell growth and survival.

        What are the mechanisms by which SRC modulates cellular adhesion and migration? 03/27/2019

        SRC modulates cellular adhesion and migration, playing a role in tissue repair and cancer metastasis.

        What is the impact of SRC inhibition on targeted cancer therapies? 01/02/2018

        SRC inhibition is a target in cancer therapy, potentially reducing tumor growth and metastasis.

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