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Active Recombinant Human USP6, GST-tagged

Cat.No. : USP6-154H
Product Overview : Recombinant human USP6 (amino acid residues 529-1406), fused with N-terminal GST, was expressed in Insect (Sf21).
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Description : The deubiquitylating – or deubiquitinating – enzymes (DUBs) represent the largest family of DCEs and regulate ubiquitin dependent signalling pathways. The activities of the DUBs include the generation of free ubiquitin from precursor molecules, the recycling of ubiquitin following substrate degradation to maintain cellular ubiquitin homeostasis and the removal of ubiquitin or ubiquitin-like proteins (UBL) modifications through chain editing to rescue proteins from proteasomal degradation or to influence cell signalling events (Komander et al., 2009).
Source : Insect cells
Species : Human
Tag : GST
Form : 50 mM HEPES pH 7.5, 150 mM sodium chloride, 2 mM dithiothreitol, 10% glycerol
Bio-activity : Deubiquitylase Enzyme Assay: The activity of GST-USP6 CD(529-1406) was validated by determining the increase in fluorescence measured as a result of the enzyme catalysed cleavage of the fluorogenic substrate Ubiquitin-Rhodamine110-Glycine generating Ubiquitin and Rhodamine110-Glycine. Incubation of the substrate in the presence or absence of GST-USP6 CD(529-1406) was compared confirming the deubiquitylating activity of GST-USP6 CD(529-1406).
Molecular Mass : ~125.3kDa
Purity : >88% by SDS-PAGE
Storage : 12 months at -70°C. Avoid multiple freeze/thaw cycles.
Concentration : 0.5 mg/ml
Gene Name : USP6 ubiquitin specific peptidase 6 (Tre-2 oncogene) [ Homo sapiens ]
Official Symbol : USP6
Synonyms : USP6; ubiquitin specific peptidase 6 (Tre-2 oncogene); HRP1, ubiquitin specific protease 6 (Tre 2 oncogene); ubiquitin carboxyl-terminal hydrolase 6; TBC1D3 and USP32 fusion; Tre 2; Tre2; TRE17; ubiquitin carboxyl terminal hydrolase 6; tre-2 oncogene; proto-oncogene TRE-2; hyperpolymorphic gene 1; ubiquitin thioesterase 6; deubiquitinating enzyme 6; ubiquitin thiolesterase 6; ubiquitin specific peptidase 6-; ubiquitin-specific protease USP6; ubiquitin-specific-processing protease 6; ubiquitin specific protease 6 (Tre-2 oncogene); HRP1; TRE2; Tre-2; USP6-short;
Gene ID : 9098
mRNA Refseq : NM_004505
Protein Refseq : NP_004496
MIM : 604334
UniProt ID : P35125
Chromosome Location : 17p13
Pathway : Arf6 signaling events, organism-specific biosystem;
Function : Rab GTPase activator activity; calmodulin binding; cysteine-type endopeptidase activity; nucleic acid binding; peptidase activity; protein binding; ubiquitin thiolesterase activity; ubiquitin-specific protease activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.



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