Active Recombinant Mouse CCL22, MIgG2a Fc-tagged
|Product Overview :||The extracellular domain of mouse CCL22 (NP_033163.1)(Gly25-Ser92) is fused to the N-terminus of the Fc portion of mouse IgG2a was expressed in CHO cell.|
- Gene Information
- Related Products
|Source :||CHO cells|
|Tag :||MIgG2a Fc-tagged|
|Form :||Lyophilized from 0.2μm-filtered solution in PBS.|
|Bio-activity :||Measured by a chemotaxis bioassay using human activated lymphocytes|
|Molecular Mass :||34 KDa|
|AA Sequence :||Gly25-Ser92|
|Endotoxin :||<0.06 eu/μg as determined by lal test.>0.06>|
|Purity :||≥98%, by SDS-PAGE under reducing conditions.|
|Stability :||Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.|
|Reconstitution :||Reconstitute at 100μg/ml in sterile PBS.|
|Warning :||Avoid freeze/thaw cycles.|
|Gene Name :||Ccl22 chemokine (C-C motif) ligand 22 [ Mus musculus ]|
|Official Symbol :||CCL22|
|Synonyms :||CCL22; chemokine (C-C motif) ligand 22; C-C motif chemokine 22; CC chemokine ABCD-1; small-inducible cytokine A22; activated B and dendritic cell-derived; small inducible cytokine subfamily A22; dendritic cell and B cell derived chemokine; small inducible cytokine subfamily A, member 22; SMALL INDUCIBLE CYTOKINE A22 PRECURSOR (CC CHEMOKINE ABCD-1) (ACTIVATED B AND DENDRITIC CELL-DERIVED); MDC; DCBCK; ABCD-1; Scya22;|
|Gene ID :||20299|
|mRNA Refseq :||NM_009137|
|Protein Refseq :||NP_033163|
|Pathway :||Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem;|
|Function :||chemokine activity; cytokine activity;|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
The expression of CCL22 gene is regulated by a variety of signaling pathways, including inflammatory factor-mediated signaling pathways, cytokine-mediated signaling pathways, and transcription factors.
Studies have shown that by interfering with the interaction of the CCL22 protein and its receptor CCR4, tumor growth, improve inflammatory response, and regulate autoimmune diseases can be inhibited. These findings provide potential application value for the development of corresponding therapeutic strategies.
A number of inhibitors or antagonists that interact with CCL22 proteins have been developed that block the binding of CCL22 to its receptor CCR4, thereby interfering with its biological function.
The mechanism of action of CCL22 protein in specific diseases can be studied through cell culture experiments, animal models, clinical samples, and related biochemical techniques.
There are complex interactions between CCL22 proteins and other chemokines. They may influence the migration and localization of immune cells by competing for receptors, mutual regulation of expression, etc.
Some studies have shown that in tumor immunotherapy, inhibiting the expression of CCL22 or interfering with its interaction with CCR4 can enhance the effect of immunotherapy and improve the survival rate of patients.
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