Active Recombinant Mouse Fgf23 Protein

Cat.No. : Fgf23-7408M
Product Overview : Recombinant murine FGF-23 is a 25.5 kDa globular protein containing 228 amino acid residues without tag was expressed in E. coli.
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  • Gene Information
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Description : This gene encodes a member of the fibroblast growth factor family. The encoded protein regulates phosphate homeostasis and vitamin D metabolism. Mutation of the related gene in humans causes autosomal dominant hypophosphatemic rickets (ADHR). The secreted protein is further cleaved into N- and C-terminal chains, which results in loss of function.
Source : E. coli
Species : Mouse
Form : Lyophilized (0.2 μm Sterile filtered) purified protein
Bio-activity : Determined by its ability to stimulate the proliferation of murine NIH-3T3 cells. The expected ED50 for this effect is 0.3-0.5 μg/mL, in the presence of murine Klotho and heparin.
Molecular Mass : 25.5 kDa
AA Sequence : MYPDTSPLLGSNWGSLTHLYTATAR TSYHLQIHRDGHVDGTPHQTIYSAL MITSEDAGSVVITGAMTRRFLCMDL HGNIFGSLHFSPENCKFRQWTLENG YDVYLSQKHHYLVSLGRAKRIFQPG TNPPPFSQFLARRNEVPLLHFYTVR PRRHTRSAEDPPERDPLNVLKPRPR ATPVPVSCSRELPSAEEGGPAASDP LGVLRRGRGDARGGAGGADRCRPFP RFV
Purity : > 95 % pure by SDS-PAGE and HPLC analyses
Stability : Shelf life: one year from despatch.
Storage : Store lyophilized at 2-8 centigrade for 6 months or at -20 centigrade long term.
After reconstitution store the antibody undiluted at 2-8 centigrade for one month or (in aliquots) at -20 centigrade long term.
Avoid repeated freezing and thawing.
Gene Name : Fgf23 fibroblast growth factor 23 [ Mus musculus (house mouse) ]
Official Symbol : Fgf23
Synonyms : Fgf23; fibroblast growth factor 23; Fgf8b; fibroblast growth factor 23; FGF-23; fibroblast growth factor 8b
Gene ID : 64654
mRNA Refseq : NM_022657
Protein Refseq : NP_073148
UniProt ID : Q9EPC2

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What role does FGF23 play in chronic kidney disease? 06/12/2022

FGF23 levels are elevated in chronic kidney disease, contributing to mineral imbalance.

How is FGF23 implicated in cardiovascular health? 04/04/2022

High FGF23 levels are associated with increased cardiovascular risk.

How does FGF23 regulate phosphate and calcium homeostasis? 03/24/2022

It decreases renal phosphate reabsorption and 1,25-dihydroxyvitamin D production.

Are there known genetic mutations that affect FGF23 production or activity? 01/27/2022

Mutations in FGF23 or related proteins can lead to dysregulated phosphate metabolism.

What therapeutic strategies are being explored to modulate FGF23 levels? 05/16/2020

Strategies include phosphate binders and FGF23 antibodies to manage elevated FGF23 levels.

In which tissues is FGF23 predominantly produced and secreted? 04/28/2020

FGF23 is primarily produced in bone.

What is the primary function of FGF23 in the body? 10/29/2019

FGF23 regulates phosphate and vitamin D metabolism.

Customer Reviews (3)

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Reviews
07/23/2022

    Excellent results, high purity. -

    07/17/2021

      Reliable and effective product. -

      11/26/2020

        Quick delivery, product works. -

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