Active Recombinant Mouse Fgf23 Protein
|Product Overview :||Recombinant murine FGF-23 is a 25.5 kDa globular protein containing 228 amino acid residues without tag was expressed in E. coli.|
- Gene Information
- Related Products
|Description :||This gene encodes a member of the fibroblast growth factor family. The encoded protein regulates phosphate homeostasis and vitamin D metabolism. Mutation of the related gene in humans causes autosomal dominant hypophosphatemic rickets (ADHR). The secreted protein is further cleaved into N- and C-terminal chains, which results in loss of function.|
|Source :||E. coli|
|Form :||Lyophilized (0.2 μm Sterile filtered) purified protein|
|Bio-activity :||Determined by its ability to stimulate the proliferation of murine NIH-3T3 cells. The expected ED50 for this effect is 0.3-0.5 μg/mL, in the presence of murine Klotho and heparin.|
|Molecular Mass :||25.5 kDa|
|AA Sequence :||MYPDTSPLLGSNWGSLTHLYTATAR TSYHLQIHRDGHVDGTPHQTIYSAL MITSEDAGSVVITGAMTRRFLCMDL HGNIFGSLHFSPENCKFRQWTLENG YDVYLSQKHHYLVSLGRAKRIFQPG TNPPPFSQFLARRNEVPLLHFYTVR PRRHTRSAEDPPERDPLNVLKPRPR ATPVPVSCSRELPSAEEGGPAASDP LGVLRRGRGDARGGAGGADRCRPFP RFV|
|Purity :||> 95 % pure by SDS-PAGE and HPLC analyses|
|Stability :||Shelf life: one year from despatch.|
|Storage :||Store lyophilized at 2-8 centigrade for 6 months or at -20 centigrade long term.
After reconstitution store the antibody undiluted at 2-8 centigrade for one month or (in aliquots) at -20 centigrade long term.
Avoid repeated freezing and thawing.
|Gene Name :||Fgf23 fibroblast growth factor 23 [ Mus musculus (house mouse) ]|
|Official Symbol :||Fgf23|
|Synonyms :||Fgf23; fibroblast growth factor 23; Fgf8b; fibroblast growth factor 23; FGF-23; fibroblast growth factor 8b|
|Gene ID :||64654|
|mRNA Refseq :||NM_022657|
|Protein Refseq :||NP_073148|
|UniProt ID :||Q9EPC2|
|◆ Recombinant Protein|
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|FGF23-1014H||Recombinant Human FGF23 Protein (Y25-R179), His tagged||+Inquiry|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (7)Ask a question
FGF23 levels are elevated in chronic kidney disease, contributing to mineral imbalance.
High FGF23 levels are associated with increased cardiovascular risk.
It decreases renal phosphate reabsorption and 1,25-dihydroxyvitamin D production.
Mutations in FGF23 or related proteins can lead to dysregulated phosphate metabolism.
Strategies include phosphate binders and FGF23 antibodies to manage elevated FGF23 levels.
FGF23 is primarily produced in bone.
FGF23 regulates phosphate and vitamin D metabolism.
Customer Reviews (3)Write a review
Excellent results, high purity. -
Reliable and effective product. -
Quick delivery, product works. -
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