Recombinant Human FGF23 Protein, GST-tagged
|Product Overview :||Human FGF23 full-length ORF (NP_065689.1, 1 a.a. - 251 a.a.) recombinant protein with GST tag at N-terminal.|
- Gene Information
- Related Products
|Description :||The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The product of this gene inhibits renal tubular phosphate transport. This gene was identified by its mutations associated with autosomal dominant hypophosphatemic rickets (ADHR), an inherited phosphate wasting disorder. Abnormally high level expression of this gene was found in oncogenic hypophosphatemic osteomalacia (OHO), a phenotypically similar disease caused by abnormal phosphate metabolism. Mutations in this gene have also been shown to cause familial tumoral calcinosis with hyperphosphatemia. [provided by RefSeq|
|Source :||Wheat Germ|
|Molecular Mass :||54.4 kDa|
|AA Sequence :||MLGARLRLWVCALCSVCSMSVLRAY PNASPLLGSSWGGLIHLYTATARNS YHLQIHKNGHVDGAPHQTIYSALMI RSEDAGFVVITGVMSRRYLCMDFRG NIFGSHYFDPENCRFQHQTLENGYD VYHSPQYHFLVSLGRAKRAFLPGMN PPPYSQFLSRRNEIPLIHFNTPIPR RHTRSAEDDSERDPLNVLKPRARMT PAPASCSQELPSAEDNSPMASDPLG VVRGGRVNTHAGGTGPEGCRPFAKF I|
|Applications :||Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
|Notes :||Best use within three months from the date of receipt of this protein.|
|Storage :||Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.|
|Storage Buffer :||50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.|
|Gene Name :||FGF23 fibroblast growth factor 23 [ Homo sapiens ]|
|Official Symbol :||FGF23|
|Synonyms :||FGF23; fibroblast growth factor 23;|
|Gene ID :||8074|
|mRNA Refseq :||NM_020638|
|Protein Refseq :||NP_065689|
|UniProt ID :||Q9GZV9|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (7)Ask a question
FGF23 levels are elevated in chronic kidney disease, contributing to mineral imbalance.
High FGF23 levels are associated with increased cardiovascular risk.
It decreases renal phosphate reabsorption and 1,25-dihydroxyvitamin D production.
Mutations in FGF23 or related proteins can lead to dysregulated phosphate metabolism.
Strategies include phosphate binders and FGF23 antibodies to manage elevated FGF23 levels.
FGF23 is primarily produced in bone.
FGF23 regulates phosphate and vitamin D metabolism.
Customer Reviews (3)Write a review
Excellent results, high purity. -
Reliable and effective product. -
Quick delivery, product works. -
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