Active Recombinant Mouse Il1f9, FLAG-tagged

• Cat.No.: Il1f9-369M
• Product Overview: Mouse IL-36γ (aa Gly13-Ser164) is fused at the C-terminus to a FLAG-tag.

Specification

• Species: Mouse
• Source: E.coli
• Tag: Flag
• Protein Length: 13-164 a.a.
• Description: IL-36alpha; (IL-1F6), IL-36beta; (IL-1F8) and IL-36gamma; (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta;, IL-6, TNF-alpha; and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.
• Form: Lyophilized. Contains PBS.
• Bio-activity: Induces secretion of IL-6 in BMDCs.
• Molecular Mass: ~17kDa
• Purity: ≥95% (SDS-PAGE)
• Stability: Stable for at least 6 months after receipt when stored at -20°C.
• Storage: Short Term Storage: +4°C; Long Term Storage: -20°C. After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions.
• Concentration: 0.1mg/ml after reconstitution.

Gene Information

• Gene Name: Il1f9 interleukin 1 family, member 9 [ Mus musculus ]
• Official Symbol: Il1f9
• Synonyms: IL1F9; interleukin 1 family, member 9; interleukin-36 gamma; IL-1F9; interleukin-1 family member 9; Il36g
• Gene ID: 215257
• mRNA Refseq: NM_153511
• Protein Refseq: NP_705731
• Function: cytokine activity; molecular_function