Active Recombinant Mouse Il1f9, FLAG-tagged
|Product Overview :||Mouse IL-36γ (aa Gly13-Ser164) is fused at the C-terminus to a FLAG-tag.|
- Gene Information
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|Description :||IL-36alpha; (IL-1F6), IL-36beta; (IL-1F8) and IL-36gamma; (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta;, IL-6, TNF-alpha; and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.|
|Source :||E. coli|
|Form :||Lyophilized. Contains PBS.|
|Bio-activity :||Induces secretion of IL-6 in BMDCs.|
|Molecular Mass :||~17kDa|
|Purity :||≥95% (SDS-PAGE)|
|Stability :||Stable for at least 6 months after receipt when stored at -20°C.|
|Storage :||Short Term Storage: +4°C; Long Term Storage: -20°C. After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions.|
|Concentration :||0.1mg/ml after reconstitution.|
|Gene Name :||Il1f9 interleukin 1 family, member 9 [ Mus musculus ]|
|Official Symbol :||Il1f9|
|Synonyms :||IL1F9; interleukin 1 family, member 9; interleukin-36 gamma; IL-1F9; interleukin-1 family member 9; Il36g;|
|Gene ID :||215257|
|mRNA Refseq :||NM_153511|
|Protein Refseq :||NP_705731|
|Function :||cytokine activity; molecular_function;|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
It is currently mainly used in the treatment of skin inflammatory diseases, and the therapeutic potential of other inflammatory diseases needs further study.
It is mainly used in the research of the mechanism of skin inflammation and the development of new drugs.
The production of IL36G usually adopts genetic engineering technology, its genes are introduced into the expression host, and pure is obtained through fermentation, purification and other steps.
IL36G can be targeted to inhibit inflammation by directly acting on inflammation-related signaling pathways, which may be more effective than other drugs.
IL36G activates inflammation-related signaling pathways by binding to its receptors, promoting the activation of immune cells and the release of inflammatory factors.
The side effects of IL36G may include skin irritation, allergic reactions, etc. The specific side effects can vary from individual to individual.
Customer Reviews (3)Write a review
During the production process, it is necessary to ensure the correct folding and structure of IL-36G similar to the natural form to ensure its function and biological activity. -
IL-36B is detected under different temperature and time conditions to observe its change in thermal stability. When producing IL-36G, it is necessary to ensure its high purity, that is, the protein does not contain other impurities, to ensure the best function and effect. -
Production of IL-36G is usually carried out by cellular expression systems, such as bacterial or mammalian cells, to produce the protein on a large scale. -
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