| Description : |
IL-36alpha; (IL-1F6), IL-36beta; (IL-1F8) and IL-36gamma; (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta;, IL-6, TNF-alpha; and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination. |
| Source : |
E. coli |
| Species : |
Mouse |
| Tag : |
FLAG |
| Form : |
Lyophilized. Contains PBS. |
| Bio-activity : |
Induces secretion of IL-6 in BMDCs. |
| Molecular Mass : |
~17kDa |
| Purity : |
≥95% (SDS-PAGE) |
| Stability : |
Stable for at least 6 months after receipt when stored at -20°C. |
| Storage : |
Short Term Storage: +4°C; Long Term Storage: -20°C. After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions. |
| Concentration : |
0.1mg/ml after reconstitution. |
