IL36G
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Official Full Name
interleukin 36, gamma
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Background
The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B) are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus infection. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B) are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus infection. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. -
Synonyms
IL 1 epsilon; IL 1 related protein 2; IL 1(EPSILON); IL 1F9; IL 1H1; IL 1RP2; IL-1 epsilon; IL-1-related protein 2; IL-1F9; IL-1H1; IL-1RP2; IL1E; Il1f9; IL1F9_HUMAN; IL1H1; IL1RP2; IL36G; Interleukin 1 epsilon; Interleukin 1 family member 9; Interleukin 1 homolog 1; Interleukin 1 related protein 2; Interleukin 36 gamma; Interleukin-1 epsilon; Interleukin-1 family member 9; Interleukin-1 homolog 1;
- Involved Pathway
- Protein Function
- Interacting Protein
- IL36G Related Articles
- IL36G Related Gene Family
- IL36G Related Research Area
IL36G involved in several pathways and played different roles in them. We selected most pathways IL36G participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with IL36G were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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IL36G has several biochemical functions, for example, cytokine activity, interleukin-1 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL36G itself. We selected most functions IL36G had, and list some proteins which have the same functions with IL36G. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | CLCF1;FAM3D;IL25;IFNA6;FGF2;NDP;GDF11;GREM2;GDF1 |
| interleukin-1 receptor binding | IL1F10;Il1f6;IL1B;IRAK1;TLR9;IL36B;IL1A;TRIP6;IL36A |
IL36G has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL36G here. Most of them are supplied by our site. Hope this information will be useful for your research of IL36G.
- Q&As
- Reviews
Q&As (6)
Ask a questionIt is currently mainly used in the treatment of skin inflammatory diseases, and the therapeutic potential of other inflammatory diseases needs further study.
It is mainly used in the research of the mechanism of skin inflammation and the development of new drugs.
The production of IL36G usually adopts genetic engineering technology, its genes are introduced into the expression host, and pure is obtained through fermentation, purification and other steps.
IL36G can be targeted to inhibit inflammation by directly acting on inflammation-related signaling pathways, which may be more effective than other drugs.
IL36G activates inflammation-related signaling pathways by binding to its receptors, promoting the activation of immune cells and the release of inflammatory factors.
The side effects of IL36G may include skin irritation, allergic reactions, etc. The specific side effects can vary from individual to individual.
Customer Reviews (3)
Write a reviewDuring the production process, it is necessary to ensure the correct folding and structure of IL-36G similar to the natural form to ensure its function and biological activity. -
IL-36B is detected under different temperature and time conditions to observe its change in thermal stability. When producing IL-36G, it is necessary to ensure its high purity, that is, the protein does not contain other impurities, to ensure the best function and effect. -
Production of IL-36G is usually carried out by cellular expression systems, such as bacterial or mammalian cells, to produce the protein on a large scale. -
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