IL36G
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Official Full Name
interleukin 36, gamma -
Overview
The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B) are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus infection. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B) are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus infection. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. -
Synonyms
IL 1 epsilon;IL 1 related protein 2;IL 1(EPSILON);IL 1F9;IL 1H1;IL 1RP2;IL-1 epsilon;IL-1-related protein 2;IL-1F9;IL-1H1;IL-1RP2;IL1E;Il1f9;IL1F9_HUMAN;IL1H1;IL1RP2;IL36G;Interleukin 1 epsilon;Interleukin 1 family member 9;Interleukin 1 homolog 1;Interleukin 1 related protein 2;Interleukin 36 gamma;Interleukin-1 epsilon;Interleukin-1 family member 9;Interleukin-1 homolog 1
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- HEK293
- Human Cells
- GST
- Flag
- Non
- His
- T7
- DDK
- Myc
Involved Pathway
IL36G involved in several pathways and played different roles in them. We selected most pathways IL36G participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with IL36G were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
IL36G has several biochemical functions, for example, cytokine activity,interleukin-1 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL36G itself. We selected most functions IL36G had, and list some proteins which have the same functions with IL36G. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| interleukin-1 receptor binding | IRAK4,IL37,IL1RAP,IL36A,IL36B,TRIP6,IL1F10,IL1RN,IL1B,IL1A |
| cytokine activity | EDN1,IL5,TNFSF18,SPP1,KITLG,IL8L2,LIF,Kitl,Il1f9,TSLP |
Interacting Protein
IL36G has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL36G here. Most of them are supplied by our site. Hope this information will be useful for your research of IL36G.
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References
- Zhao, YL; Xu, RT; et al. Protective efficacy in chickens of recombinant plasmid pET32a(+)-ADF-3-1E of Eimeria acervulina. PARASITOLOGY RESEARCH 113:3007-3014(2014).
- Vossenkamper, A; Hundsrucker, C; et al. A CD3-Specific Antibody Reduces Cytokine Production and Alters Phosphoprotein Profiles in Intestinal Tissues From Patients With Inflammatory Bowel Disease. GASTROENTEROLOGY 147:172-183(2014).
