IL36G

  • Official Full Name

    interleukin 36, gamma

  • Background

    The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B) are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus infection. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B) are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus infection. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
  • Synonyms

    IL 1 epsilon; IL 1 related protein 2; IL 1(EPSILON); IL 1F9; IL 1H1; IL 1RP2; IL-1 epsilon; IL-1-related protein 2; IL-1F9; IL-1H1; IL-1RP2; IL1E; Il1f9; IL1F9_HUMAN; IL1H1; IL1RP2; IL36G; Interleukin 1 epsilon; Interleukin 1 family member 9; Interleukin 1 homolog 1; Interleukin 1 related protein 2; Interleukin 36 gamma; Interleukin-1 epsilon; Interleukin-1 family member 9; Interleukin-1 homolog 1;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cells
    • Tag :
    • Flag
    • GST
    • His
    • His(C
    • ter)
    • His|T7
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IL36G-7270H Recombinant Human IL36G, None tagged E.coli N/A
    Human IL36G-754H Recombinant Human IL36G protein, His-tagged E.coli N/A
    Human IL1F9-14173H Recombinant Human IL1F9, GST-tagged E.coli GST
    Human IL36G-5235HCL Recombinant Human IL1F9 293 Cell Lysate HEK293 N/A
    Human IL36G-13H Recombinant Human IL36G Protein, His-tagged E.coli His
    Human IL36G-5107H Recombinant Human IL36G Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human IL36G-15880H Recombinant Human IL36B, His-tagged E.coli His
    Human IL36G-511H Recombinant Human IL36G protein E.coli N/A
    Human IL36G-510H Recombinant Human IL36G protein E.coli N/A
    Human IL36G-4844H Recombinant Human IL36G protein, GST-tagged E.coli GST
    Human IL36G-7516H Recombinant Human IL36G protein, His-tagged E.coli His
    Human IL36G-198H Recombinant Active Human IL36G Protein, His-tagged(C-ter) E.coli His(C-ter)
    Human IL36G-141H Active Recombinant Human IL36G protein E.coli N/A
    Human IL36G-85H Recombinant Human IL36G Protein E.coli
    Human IL36G-151H Recombinant Human IL36G Protein, His-tagged Human Cells His
    Human IL36G-2584H Recombinant Human IL36G protein E.coli N/A
    Mouse Il36g-176M Recombinant Mouse Il36g Protein E.coli
    Mouse Il1f9-648M Recombinant Mouse Il1f9 protein E.coli N/A
    Mouse Il36g-199M Recombinant Active Mouse IL36G Protein, His-tagged(C-ter) E.coli His(C-ter)
    Mouse Il36g-1309M Recombinant Mouse Il36g protein, His-tagged E.coli His
    Mouse Il36g-01M Active Recombinant Mouse Il36g Protein, His-Tagged E.coli His
    Mouse Il1f9-369M Active Recombinant Mouse Il1f9, FLAG-tagged E.coli Flag
    Mouse Il1f9-155M Recombinant Mouse Il1f9, His tagged E.coli GST
    Mouse Il1f9-1864M Recombinant Mouse Il1f9 protein, His-tagged E.coli His
    Rat Il36g-1865R Recombinant Rat Il36g protein, His & T7-tagged E.coli His/T7
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • IL36G Related Articles
    • IL36G Related Gene Family
    • IL36G Related Research Area

    IL36G involved in several pathways and played different roles in them. We selected most pathways IL36G participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with IL36G were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    IL36G has several biochemical functions, for example, cytokine activity, interleukin-1 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL36G itself. We selected most functions IL36G had, and list some proteins which have the same functions with IL36G. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activityCLCF1;FAM3D;IL25;IFNA6;FGF2;NDP;GDF11;GREM2;GDF1
    interleukin-1 receptor bindingIL1F10;Il1f6;IL1B;IRAK1;TLR9;IL36B;IL1A;TRIP6;IL36A

    IL36G has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL36G here. Most of them are supplied by our site. Hope this information will be useful for your research of IL36G.

    Zhao, YL; Xu, RT; et al. Protective efficacy in chickens of recombinant plasmid pET32a(+)-ADF-3-1E of Eimeria acervulina. PARASITOLOGY RESEARCH 113:3007-3014(2014).
    Vossenkamper, A; Hundsrucker, C; et al. A CD3-Specific Antibody Reduces Cytokine Production and Alters Phosphoprotein Profiles in Intestinal Tissues From Patients With Inflammatory Bowel Disease. GASTROENTEROLOGY 147:172-183(2014).
    IL
    • Q&As
    • Reviews

    Q&As (6)

    Ask a question
    Can IL36G treat other inflammatory diseases? 10/17/2022

    It is currently mainly used in the treatment of skin inflammatory diseases, and the therapeutic potential of other inflammatory diseases needs further study.

    What are the main application areas of IL36G in scientific research? 08/27/2022

    It is mainly used in the research of the mechanism of skin inflammation and the development of new drugs.

    What is the production process of IL36G? 06/10/2021

    The production of IL36G usually adopts genetic engineering technology, its genes are introduced into the expression host, and pure is obtained through fermentation, purification and other steps.

    What are the advantages of IL36G in the treatment of skin inflammation compared with other drugs? 10/13/2020

    IL36G can be targeted to inhibit inflammation by directly acting on inflammation-related signaling pathways, which may be more effective than other drugs.

    What is the mechanism of action of IL36G? 06/09/2020

    IL36G activates inflammation-related signaling pathways by binding to its receptors, promoting the activation of immune cells and the release of inflammatory factors.

    What are the side effects of IL36G? 05/14/2020

    The side effects of IL36G may include skin irritation, allergic reactions, etc. The specific side effects can vary from individual to individual.

    Customer Reviews (3)

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    Reviews
    05/29/2022

      During the production process, it is necessary to ensure the correct folding and structure of IL-36G similar to the natural form to ensure its function and biological activity. -

      04/14/2022

        IL-36B is detected under different temperature and time conditions to observe its change in thermal stability. When producing IL-36G, it is necessary to ensure its high purity, that is, the protein does not contain other impurities, to ensure the best function and effect. -

        01/06/2022

          Production of IL-36G is usually carried out by cellular expression systems, such as bacterial or mammalian cells, to produce the protein on a large scale. -

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