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Recombinant Human IL36G Protein, His-tagged

Cat.No. : IL36G-13H
Product Overview : Recombinant human IL36B protein (1-169aa), fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
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Description : The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B) are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus infection. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
Source : E.coli
Species : Human
Tag : His
Form : Liquid
Molecular Mass : 21.1 kDa confirmed by MALDI-TOF
Identity : 192aa
AA Sequence : MGSSHHHHHHSSGLVPRGSHMGSMR GTPGDADGGGRAVYQSMCKPITGTI NDLNQQVWTLQGQNLVAVPRSDSVT PVTVAVITCKYPEALEQGRGDPIYL GIQNPEMCLYCEKVGEQPTLQLKEQ KIMDLYGQPEPVKPFLFYRAKTGRT STLESVAFPDWFIASSKRDQPIILT SELGKSYNTAFELNIND
Endotoxin : < 1 EU/μg of protein (determined by LAL method)
Purity : > 95% by SDS-PAGE
Applications : SDS-PAGE
Storage : Can be stored at 2 to 8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
Concentration : 1 mg/mL (determined by BCA assay)
Storage Buffer : 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol
Gene Name : IL36G interleukin 36 gamma [ Homo sapiens (human) ]
Official Symbol : IL36G
Synonyms : IL36G; interleukin 36 gamma; IL1E; IL1F9; IL1H1; IL-1F9; IL-1H1; IL1RP2; IL-1RP2; interleukin-36 gamma; IL-1 related protein 2; IL-1-epsilon; interleukin 1-related protein 2; interleukin-1 epsilon; interleukin-1 family member 9; interleukin-1 homolog 1
Gene ID : 56300
mRNA Refseq : NM_019618
Protein Refseq : NP_062564
MIM : 605542
UniProt ID : Q9NZH8

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Can IL36G treat other inflammatory diseases? 10/17/2022

It is currently mainly used in the treatment of skin inflammatory diseases, and the therapeutic potential of other inflammatory diseases needs further study.

What are the main application areas of IL36G in scientific research? 08/27/2022

It is mainly used in the research of the mechanism of skin inflammation and the development of new drugs.

What is the production process of IL36G? 06/10/2021

The production of IL36G usually adopts genetic engineering technology, its genes are introduced into the expression host, and pure is obtained through fermentation, purification and other steps.

What are the advantages of IL36G in the treatment of skin inflammation compared with other drugs? 10/13/2020

IL36G can be targeted to inhibit inflammation by directly acting on inflammation-related signaling pathways, which may be more effective than other drugs.

What is the mechanism of action of IL36G? 06/09/2020

IL36G activates inflammation-related signaling pathways by binding to its receptors, promoting the activation of immune cells and the release of inflammatory factors.

What are the side effects of IL36G? 05/14/2020

The side effects of IL36G may include skin irritation, allergic reactions, etc. The specific side effects can vary from individual to individual.

Customer Reviews (3)

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Reviews
05/29/2022

    When experimenting with IL36G, the results are very reproducible.

    04/14/2022

      Production process of IL36G products is environmentally friendly and sustainable, in line with the concept of green production.

      01/06/2022

        IL36G has good solubility and ion exchange ability, which is convenient for subsequent experimental treatment and purification.

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