Recombinant Human IL36G Protein, His-tagged
|Product Overview :||Recombinant human IL36B protein (1-169aa), fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
- Gene Information
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|Description :||The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B) are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus infection. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.|
|Molecular Mass :||21.1 kDa confirmed by MALDI-TOF|
|AA Sequence :||MGSSHHHHHHSSGLVPRGSHMGSMR GTPGDADGGGRAVYQSMCKPITGTI NDLNQQVWTLQGQNLVAVPRSDSVT PVTVAVITCKYPEALEQGRGDPIYL GIQNPEMCLYCEKVGEQPTLQLKEQ KIMDLYGQPEPVKPFLFYRAKTGRT STLESVAFPDWFIASSKRDQPIILT SELGKSYNTAFELNIND|
|Endotoxin :||< 1 EU/μg of protein (determined by LAL method)|
|Purity :||> 95% by SDS-PAGE|
|Storage :||Can be stored at 2 to 8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.|
|Concentration :||1 mg/mL (determined by BCA assay)|
|Storage Buffer :||20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol|
|Gene Name :||IL36G interleukin 36 gamma [ Homo sapiens (human) ]|
|Official Symbol :||IL36G|
|Synonyms :||IL36G; interleukin 36 gamma; IL1E; IL1F9; IL1H1; IL-1F9; IL-1H1; IL1RP2; IL-1RP2; interleukin-36 gamma; IL-1 related protein 2; IL-1-epsilon; interleukin 1-related protein 2; interleukin-1 epsilon; interleukin-1 family member 9; interleukin-1 homolog 1|
|Gene ID :||56300|
|mRNA Refseq :||NM_019618|
|Protein Refseq :||NP_062564|
|UniProt ID :||Q9NZH8|
|IL36G-5235HCL||Recombinant Human IL1F9 293 Cell Lysate||+Inquiry|
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
It is currently mainly used in the treatment of skin inflammatory diseases, and the therapeutic potential of other inflammatory diseases needs further study.
It is mainly used in the research of the mechanism of skin inflammation and the development of new drugs.
The production of IL36G usually adopts genetic engineering technology, its genes are introduced into the expression host, and pure is obtained through fermentation, purification and other steps.
IL36G can be targeted to inhibit inflammation by directly acting on inflammation-related signaling pathways, which may be more effective than other drugs.
IL36G activates inflammation-related signaling pathways by binding to its receptors, promoting the activation of immune cells and the release of inflammatory factors.
The side effects of IL36G may include skin irritation, allergic reactions, etc. The specific side effects can vary from individual to individual.
Customer Reviews (3)Write a review
When experimenting with IL36G, the results are very reproducible. -
Production process of IL36G products is environmentally friendly and sustainable, in line with the concept of green production. -
IL36G has good solubility and ion exchange ability, which is convenient for subsequent experimental treatment and purification. -
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